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The map label for this gene is edd [H]

Identifier: 117920593

GI number: 117920593

Start: 2573951

End: 2575777

Strand: Reverse

Name: edd [H]

Synonym: Shewana3_2149

Alternate gene names: 117920593

Gene position: 2575777-2573951 (Counterclockwise)

Preceding gene: 117920594

Following gene: 117920592

Centisome position: 51.8

GC content: 51.29

Gene sequence:

>1827_bases
ATGCACTCAGTCGTTCAATCTGTTACCGACAGAATTATTGCCCGTAGCAAAGCATCTCGTGAAGCGTATTTAGCCGCGTT
AAATGATGCTCGTAACCATGGCGTACACCGTAGCTCCTTAAGCTGCGGTAACTTAGCCCACGGTTTTGCTGCTTGTAGTC
CAGATGACAAAAATTCATTGCGTCAACTGACCAAAGCTAACATCGGGATTATTACCGCATTCAACGATATGTTGTCTGCA
CACCAACCCTATGAAACCTATCCTGAATTGCTGAAAAAAGCTTGTCAGGAAGTGGGCAGTGTTGCACAGGTCGCAGGTGG
TGTACCTGCAATGTGTGACGGTGTGACTCAAGGTCAACCCGGGATGGAACTGAGCTTACTGAGTCGTGAAGTGATTGCCA
TGGCGACGGCGGTGGGCTTATCCCACAACATGTTTGATGGCGCCTTATTACTGGGTATCTGCGACAAAATCGTGCCGGGC
TTATTGATTGGCGCCTTAAGTTTTGGCCATTTACCTATGCTGTTTGTGCCTGCAGGCCCAATGAAGTCGGGGATCCCAAA
CAAGGAAAAAGCCCGTATTCGCCAGCAATTTGCCCAAGGTAAAGTCGATAGAGCGCAGCTGCTTGAAGCCGAAGCGCAGT
CTTATCACAGCGCTGGCACTTGTACCTTCTACGGTACGGCTAACTCGAACCAGCTGATGCTCGAAGTCATGGGGCTGCAA
TTGCCGGGTTCATCCTTTGTGAATCCTGACGACCCACTGCGTGAAGCGCTGAATAAAATGGCGGCCAAGCAGGTGTGCCG
CTTAACAGAGCTTGGCACTCAATACAGCCCAATCGGTGAAGTGGTTAACGAGAAATCCGTGGTGAACGGCATAGTGGCGC
TACTGGCAACGGGTGGTTCAACTAACTTAACCATGCACATTGTGGCGGCGGCGCGTGCGGCTGGCATTATCGTGAACTGG
GATGATTTTTCTGAATTATCTGACGCGGTTCCTTTGCTGGCCCGTGTTTATCCAAACGGTCATGCGGACATTAACCACTT
CCACGCCGCGGGCGGTATGGCTTTCCTTATCAAGGAATTACTCGACGCGGGCCTCCTACATGAGGATGTCAACACAGTTG
CCGGTTTTGGTCTACGTCGTTACACCCAAGAGCCAAAATTACTCGATGGCGAGCTGCGCTGGGTCGATGGTCCAACCGTC
AGCTTAGATACTGAAGTATTAACGTCTGTCGCTACGCCTTTCCAAAACAACGGTGGCTTAAAACTGCTTAAGGGCAACTT
GGGCCGTGCGGTGATTAAAGTGTCAGCCGTGCAAGAAAAACACCGTGTAGTTGAAGCGCCTGCCGTGGTGATTGACGATC
AAAACAAACTCGATGCGCTGTTTAAATCCGGCGCATTAGACCGAGATTGTGTGGTGGTAGTTAAAGGCCAAGGGCCGAAA
GCGAACGGTATGCCTGAGCTGCACAAGTTAACGCCACTGTTAGGCTCTCTGCAGGATAAAGGCTTTAAAGTGGCTCTGAT
GACCGACGGTCGTATGTCGGGCGCATCGGGCAAAGTACCAGCCGCAATTCACTTAACGCCAGAGGCTATCGATGGAGGGC
TAATTGCCAAAGTGCAAGATGGCGATCTGATTCGTGTCGACGCACTGACCGGTGAGCTGAGCTTATTGGTCTCCGATGCC
GAACTTGCCGCGAGAACCGCCGCTGAAATCGATTTACGCCACTCACGCTATGGAATGGGCCGTGAGTTGTTTGGGGCACT
GCGTTCAAATTTAAGCAGTCCAGAAACTGGTGCGCGCAGTACCAGCGCCATTGACGAACTTTATTAA

Upstream 100 bases:

>100_bases
CTTAGAAAATGATGATGTTAATGCTATGCCCATCAGAGCCGTATTAGCGCAGCGTAAAACGCCCGTTGACGTGTTCTGGA
GCGCTTAAGGAGTCACTCTC

Downstream 100 bases:

>100_bases
TACAAAGGAAGAATACCGCAATGCTTGAGAATAACTGGTCATTACAACCACAAGATATTTTTAAACGCAGCCCTATTGTT
CCTGTTATGGTCATTAACAA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MHSVVQSVTDRIIARSKASREAYLAALNDARNHGVHRSSLSCGNLAHGFAACSPDDKNSLRQLTKANIGIITAFNDMLSA
HQPYETYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTELGTQYSPIGEVVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTV
SLDTEVLTSVATPFQNNGGLKLLKGNLGRAVIKVSAVQEKHRVVEAPAVVIDDQNKLDALFKSGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGSLQDKGFKVALMTDGRMSGASGKVPAAIHLTPEAIDGGLIAKVQDGDLIRVDALTGELSLLVSDA
ELAARTAAEIDLRHSRYGMGRELFGALRSNLSSPETGARSTSAIDELY

Sequences:

>Translated_608_residues
MHSVVQSVTDRIIARSKASREAYLAALNDARNHGVHRSSLSCGNLAHGFAACSPDDKNSLRQLTKANIGIITAFNDMLSA
HQPYETYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTELGTQYSPIGEVVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTV
SLDTEVLTSVATPFQNNGGLKLLKGNLGRAVIKVSAVQEKHRVVEAPAVVIDDQNKLDALFKSGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGSLQDKGFKVALMTDGRMSGASGKVPAAIHLTPEAIDGGLIAKVQDGDLIRVDALTGELSLLVSDA
ELAARTAAEIDLRHSRYGMGRELFGALRSNLSSPETGARSTSAIDELY
>Mature_608_residues
MHSVVQSVTDRIIARSKASREAYLAALNDARNHGVHRSSLSCGNLAHGFAACSPDDKNSLRQLTKANIGIITAFNDMLSA
HQPYETYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQPGMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPG
LLIGALSFGHLPMLFVPAGPMKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
LPGSSFVNPDDPLREALNKMAAKQVCRLTELGTQYSPIGEVVNEKSVVNGIVALLATGGSTNLTMHIVAAARAAGIIVNW
DDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKELLDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTV
SLDTEVLTSVATPFQNNGGLKLLKGNLGRAVIKVSAVQEKHRVVEAPAVVIDDQNKLDALFKSGALDRDCVVVVKGQGPK
ANGMPELHKLTPLLGSLQDKGFKVALMTDGRMSGASGKVPAAIHLTPEAIDGGLIAKVQDGDLIRVDALTGELSLLVSDA
ELAARTAAEIDLRHSRYGMGRELFGALRSNLSSPETGARSTSAIDELY

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=598, Percent_Identity=67.8929765886288, Blast_Score=842, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=548, Percent_Identity=29.3795620437956, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=495, Percent_Identity=29.8989898989899, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786464, Length=480, Percent_Identity=29.7916666666667, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322476, Length=501, Percent_Identity=30.1397205588822, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64497; Mature: 64497

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSVVQSVTDRIIARSKASREAYLAALNDARNHGVHRSSLSCGNLAHGFAACSPDDKNSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCHHHH
RQLTKANIGIITAFNDMLSAHQPYETYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQP
HHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREALNKMAAKQVCRLTELGTQYSPIGEVVNEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTVSLDTEVLTSVATPFQNNGGL
HHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEECCCCEEECHHHHHHHHCCCCCCCCE
KLLKGNLGRAVIKVSAVQEKHRVVEAPAVVIDDQNKLDALFKSGALDRDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPLLGSLQDKGFKVALMTDGRMSGASGKVPAAIHLTPEAIDGGLIAKVQD
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRVDALTGELSLLVSDAELAARTAAEIDLRHSRYGMGRELFGALRSNLSSPETGARS
CCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
TSAIDELY
HHHHHHCC
>Mature Secondary Structure
MHSVVQSVTDRIIARSKASREAYLAALNDARNHGVHRSSLSCGNLAHGFAACSPDDKNSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCHHHH
RQLTKANIGIITAFNDMLSAHQPYETYPELLKKACQEVGSVAQVAGGVPAMCDGVTQGQP
HHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMATAVGLSHNMFDGALLLGICDKIVPGLLIGALSFGHLPMLFVPAGP
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MKSGIPNKEKARIRQQFAQGKVDRAQLLEAEAQSYHSAGTCTFYGTANSNQLMLEVMGLQ
CCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECEE
LPGSSFVNPDDPLREALNKMAAKQVCRLTELGTQYSPIGEVVNEKSVVNGIVALLATGGS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHIVAAARAAGIIVNWDDFSELSDAVPLLARVYPNGHADINHFHAAGGMAFLIKEL
CCEEEEEEEHHHHCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHH
LDAGLLHEDVNTVAGFGLRRYTQEPKLLDGELRWVDGPTVSLDTEVLTSVATPFQNNGGL
HHHHHHHHHHHHHHHCHHHHHCCCCCCCCCEEEEECCCCEEECHHHHHHHHCCCCCCCCE
KLLKGNLGRAVIKVSAVQEKHRVVEAPAVVIDDQNKLDALFKSGALDRDCVVVVKGQGPK
EEEECCCCCEEEEHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCEEEEEECCCCC
ANGMPELHKLTPLLGSLQDKGFKVALMTDGRMSGASGKVPAAIHLTPEAIDGGLIAKVQD
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECHHHCCCCEEEEECC
GDLIRVDALTGELSLLVSDAELAARTAAEIDLRHSRYGMGRELFGALRSNLSSPETGARS
CCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
TSAIDELY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]