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The map label for this gene is pdhA [H]

Identifier: 117920575

GI number: 117920575

Start: 2556482

End: 2557660

Strand: Reverse

Name: pdhA [H]

Synonym: Shewana3_2131

Alternate gene names: 117920575

Gene position: 2557660-2556482 (Counterclockwise)

Preceding gene: 117920576

Following gene: 117920574

Centisome position: 51.44

GC content: 49.87

Gene sequence:

>1179_bases
ATGAGCAAAGCAACACTCAACACTGATACAGTGCACCGTGTCGGCTTCTTGGATAAGGCATCGCTTCACATTCCTATCCT
TCGAATTCTACAAGCAGACGGCACTACCTATGAAACCGCGGTTTTGCCTGTAATAGATGAAGCCTTAGCCACCAAAATTT
ACGATACTTGCGTATTCACGCGGGTACTCGACGAACGTATGTTAGGCGCACAGCGTCAGGGACGGATCAGCTTCTATATG
ACCTGTACGGGTGAAGAAGCGGCGATCGTCGGCAGTGTCGCGGCGCTTGATCAAGAAGATGTGATCCTCGCGCAATATCG
TGAACATGCGGCGCTGCGTTACCGTGGTTTTACCACTGAGCAGTTTATGAACCAAATGTTCAGCAATGAGAAGGACTTAG
GTAAAGGTCGCCAAATGCCAATTCACTACGGCTGCGCGGCGTTAAACTACCAAACCATTTCATCGCCACTGGCCACGCAA
ATCCCGCAAGCGACAGGTGTCGGTTATAGCCTGAAAATGCAGGGCAAACGTAATGTTGCCGTCTGTTATTTCGGTGAAGG
CGCTGCCTCTGAAGGTGACTTCCACGCAGGCTTGAATATGGCTGCGGTGTTAAAATGCCCGGTGATTTTCTTCTGCCGTA
ACAATGGTTATGCGATTTCCACCCCAACAGAAGAACAGTTTGCCGGTAACGGTATCGCTAGCCGCGGTGTGGGTTACGGT
ATGCACACCATTCGTGTCGACGGTAACGATATGCTGGCGGTGTTAGCGGCGACGCAACAGGCGCGTGCCTATGCAATTGA
GCATAATGCTCCCGTGTTGATTGAAGCCATGACTTATCGCCTTGGCGCGCACTCATCTTCTGACGATCCTTCTGGCTATC
GCTCCAAAGAAGAAGAGGCAAAATGGCAGCAACACGATCCAGTCAAACGCTTCAAGTTATGGTTGATCAACAAAGGCTGG
TTGGCCGAGGCCGATGATGCCCAGCGTTACGAAAAGTACCGTGAAGAAGTGTTAGCCGCCGTTAAAGTCGCTGAAAAATT
ACCTATCCCTATGCTGGATGAGATCATTGAAGATGTGTACGACAAGCCAACACCAGCGCTGAAAAAGCAGCTGAGTGAAC
TTAAAGAACACATCAAGAAATATCCGCAATCCTATCCCAAAAGTGCAGGGAGGCTATAA

Upstream 100 bases:

>100_bases
TTGATAGGTAGTTTACGTTAACGTAATGTTCATCCGGCATATTCGTATAAATTAGGCGTTGTGGATTTTCCATGGCGTAA
CGAGATAACAAGAGCACAAT

Downstream 100 bases:

>100_bases
GCCGTGGCAGAAATGAATATGTTACAGGCCGTCAATGAGGCCTTGTCTATCGCCATGCAATCTGACGAGCGCATGGTGGT
ATTTGGTGAAGACGTTGGCC

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDEALATKIYDTCVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGCAALNYQTISSPLATQ
IPQATGVGYSLKMQGKRNVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKEEEAKWQQHDPVKRFKLWLINKGW
LAEADDAQRYEKYREEVLAAVKVAEKLPIPMLDEIIEDVYDKPTPALKKQLSELKEHIKKYPQSYPKSAGRL

Sequences:

>Translated_392_residues
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDEALATKIYDTCVFTRVLDERMLGAQRQGRISFYM
TCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGCAALNYQTISSPLATQ
IPQATGVGYSLKMQGKRNVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKEEEAKWQQHDPVKRFKLWLINKGW
LAEADDAQRYEKYREEVLAAVKVAEKLPIPMLDEIIEDVYDKPTPALKKQLSELKEHIKKYPQSYPKSAGRL
>Mature_391_residues
SKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDEALATKIYDTCVFTRVLDERMLGAQRQGRISFYMT
CTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTEQFMNQMFSNEKDLGKGRQMPIHYGCAALNYQTISSPLATQI
PQATGVGYSLKMQGKRNVAVCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYGM
HTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKEEEAKWQQHDPVKRFKLWLINKGWL
AEADDAQRYEKYREEVLAAVKVAEKLPIPMLDEIIEDVYDKPTPALKKQLSELKEHIKKYPQSYPKSAGRL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=364, Percent_Identity=49.7252747252747, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI258645172, Length=364, Percent_Identity=49.7252747252747, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI291084742, Length=290, Percent_Identity=31.0344827586207, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4505685, Length=290, Percent_Identity=31.0344827586207, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4885543, Length=322, Percent_Identity=27.639751552795, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI291084744, Length=283, Percent_Identity=30.7420494699647, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI291084757, Length=291, Percent_Identity=28.1786941580756, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=365, Percent_Identity=51.2328767123288, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI86563355, Length=365, Percent_Identity=51.2328767123288, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17536047, Length=299, Percent_Identity=30.4347826086957, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564172, Length=299, Percent_Identity=30.4347826086957, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=358, Percent_Identity=26.2569832402235, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355903, Length=366, Percent_Identity=46.7213114754098, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24639746, Length=301, Percent_Identity=30.8970099667774, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24639740, Length=301, Percent_Identity=30.8970099667774, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24639744, Length=301, Percent_Identity=30.8970099667774, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28571106, Length=301, Percent_Identity=30.8970099667774, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24639748, Length=299, Percent_Identity=29.7658862876254, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 43575; Mature: 43444

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDEALATKIYDTCVFT
CCCCCCCCCHHHHHCCCCCCCCCHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCCCEEHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGCAALNYQTISSPLATQIPQATGVGYSLKMQGKRNVA
HHHHHHHCCCCCCCCCCCCCEEECCEEECHHHHCCHHHHHCCCCCCCCEEEEECCCCCEE
VCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKEEEA
EEEEEECCCCEEEEEEHHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHH
KWQQHDPVKRFKLWLINKGWLAEADDAQRYEKYREEVLAAVKVAEKLPIPMLDEIIEDVY
HHHHCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DKPTPALKKQLSELKEHIKKYPQSYPKSAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SKATLNTDTVHRVGFLDKASLHIPILRILQADGTTYETAVLPVIDEALATKIYDTCVFT
CCCCCCCCHHHHHCCCCCCCCCHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHH
RVLDERMLGAQRQGRISFYMTCTGEEAAIVGSVAALDQEDVILAQYREHAALRYRGFTTE
HHHHHHHHCCCCCCCEEEEEEECCCCCCEEHHHHHCCCCCHHHHHHHHHHHHEECCCCHH
QFMNQMFSNEKDLGKGRQMPIHYGCAALNYQTISSPLATQIPQATGVGYSLKMQGKRNVA
HHHHHHHCCCCCCCCCCCCCEEECCEEECHHHHCCHHHHHCCCCCCCCEEEEECCCCCEE
VCYFGEGAASEGDFHAGLNMAAVLKCPVIFFCRNNGYAISTPTEEQFAGNGIASRGVGYG
EEEECCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCEEECCCCHHHHCCCCCCCCCCCCC
MHTIRVDGNDMLAVLAATQQARAYAIEHNAPVLIEAMTYRLGAHSSSDDPSGYRSKEEEA
EEEEEECCCCEEEEEEHHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHH
KWQQHDPVKRFKLWLINKGWLAEADDAQRYEKYREEVLAAVKVAEKLPIPMLDEIIEDVY
HHHHCCCHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
DKPTPALKKQLSELKEHIKKYPQSYPKSAGRL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA