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The map label for this gene is pyrD [H]

Identifier: 117920233

GI number: 117920233

Start: 2110240

End: 2111259

Strand: Direct

Name: pyrD [H]

Synonym: Shewana3_1786

Alternate gene names: 117920233

Gene position: 2110240-2111259 (Clockwise)

Preceding gene: 117920232

Following gene: 117920234

Centisome position: 42.44

GC content: 42.06

Gene sequence:

>1020_bases
ATGTTTTATAAAATCGCACAGAAAGTCATGTTTCAGATGGATCCTGAGCGAGCGCATAATCTAGCCATTGGCAGCCTGAA
AATGACAGGCAACAGCCCATTGAATGCGTTTTATGCCCAGAATATTGCGCCAGCGCCCGTCAGCTTTATGGGACTGACTT
TTCCAAACCCTGTCGGTCTTGCCGCAGGTATGGATAAAGATGGCGAATCGATCGATGCCTTTCATGCGATGGGATTTGGT
CATGTTGAAGTGGGCACTGTGACCCCAAGACCACAACCCGGTAATGATTTACCCCGTTTATTTAGATTAAAACCTGCAAA
GGCGATCATTAATCGCATGGGTTTTAATAACAAAGGTGTCGATAATCTGGTCAAAAATTTGATCGCAAAGAAAACCGATA
TCATGGTTGGGGTCAATATTGGTAAAAATAAAGACACTCCAGTAGAGCAGGGCAAAGACGATTATTTGATCTGCATGGAT
AAAGTTTATCCCTATGCGGCCTATATTGCGGTGAATATTTCATCACCGAATACACCCGGATTACGATCGCTGCAATATGG
CGATCTATTAGATGAATTATTAAGCGCATTAAAAACCAAGCAACTTGAGTTGGCCGAGAAACATAAAAAATATGTGCCAA
TTGCCCTTAAAATTGCGCCCGATTTAACCACGGAAGAAATCGAAAATATTGCGCAATCCTTGATTAAAAACAAGTTTGAT
GGTGCGATTGCGACTAACACAACGTTAACCCGTGACGGTGTAAGCGGCCTTGCGAATGCCAATGAAAGTGGTGGGTTAAG
TGGTAAGCCATTGACAGAGCTTTCAACTAAAGTGATCAAACAATTAGCCACCGGTTTAAATGGCCAGATCCCGATCATTG
GTGTTGGTGGAATTAACAGTGCTGAAGATGCGTTAGCAAAATTTGATGCCGGCGCGACTATGGTACAGATTTACTCAGGT
TTTATTTACCAGGGTCCAAAGTTAATTAAAGAAATTGTTGAAGCTTATCGCTTAAAATAA

Upstream 100 bases:

>100_bases
TGAACCTTCTGATCCTTCATTGCGAAGGCCATAAGTAAACTTTTATAACAATCAGAAGCCCTGGCGATCGCCGGGGCTTT
TTTTAGGTCGAGGAAAATAC

Downstream 100 bases:

>100_bases
TGATCTTTAGATCAATATAGGATCTAAAATAGGATCTAAAATAGGATCTTTTAATAATAACTGCGATCTAAAACGATCAT
TAGATCGCAGTTAAGATCTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATGLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Sequences:

>Translated_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATGLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK
>Mature_339_residues
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYPYAAYIAVNISSPNTPGLRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATGLNGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVEAYRLK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=43.030303030303, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=61.8618618618619, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17509475, Length=351, Percent_Identity=41.3105413105413, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI281361352, Length=326, Percent_Identity=42.0245398773006, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17137316, Length=326, Percent_Identity=42.0245398773006, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36553; Mature: 36553

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHCCCCCCCHHEEECCCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATGLNGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQKVMFQMDPERAHNLAIGSLKMTGNSPLNAFYAQNIAPAPVSFMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHCEEEEEEEECCCCCCHHHHHCCCCCCCHHEEECCCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKAIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYPYAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSALKTKQLELAEKHKKYVPIALKIAPDLTTEEIENIAQSLIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLATGLNGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVEAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA