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The map label for this gene is phoP [H]

Identifier: 117920171

GI number: 117920171

Start: 2027425

End: 2028108

Strand: Reverse

Name: phoP [H]

Synonym: Shewana3_1724

Alternate gene names: 117920171

Gene position: 2028108-2027425 (Counterclockwise)

Preceding gene: 117920172

Following gene: 117920170

Centisome position: 40.79

GC content: 46.64

Gene sequence:

>684_bases
ATGAGAATTATGAGAATTTTGGTTGTTGAAGATGATCTTATTTTATCCCACCATCTAAAAGTACAGTTAAGCGATTTGGG
CAACCAAGTTCAAGTCGCCCTCACCGCCAAGGAAGGATTCTTCCAAGCGACTAACTATCCCATCGATGTGGCCATCGTCG
ATTTAGGTTTACCCGATCAAGACGGCATTAGTCTTATACAACAATTACGCGAAGAAGGCGTTAAGGCGCCTATCTTAATC
CTAACGGCCCGAGTTAACTGGCAAGATAAAGTTGAAGGCCTCAACGCGGGTGCCGACGACTATTTAGTCAAACCCTTCCA
GAAAGAAGAACTGGTTGCCAGACTCGACGCCTTAGTCAGACGCAGCGCAGGCTTTGTTAAACCCGTTATCACCAGTGGTG
AGTTAAAACTCGATCTTGCCGCTAAACAGGTCACCCTCGCGAATGAAGTCATGGAAGTCACTGCCTTTGAATACCTCATC
TTGGAATATCTGATGCGCCATTGCCATGAAGTCGTCGCCAAACAGCGGCTACTGGATGTGATTTACGGCGACAAAGAAGG
CGATCCTAACACCATTGAGGTTATGGTGAGCCGTCTACGTAAAAAACTCACCCGCGACGGCATAGACAACCCTATTGTGA
CCATCCGTGGCCAAGGTTATAAATTCAATCTGCCATGCAATTAA

Upstream 100 bases:

>100_bases
TAGCTTGGTCAGCCGAGGTTAAGTTGCCATTGGCTAAAATAAGACAATATTTGGCTCCCGCGTATATTTTGCGTACACTG
AGTCCAGTCGACTTTAAGGC

Downstream 100 bases:

>100_bases
GACTCAAAATGAAGAAACGTCTGCTCACGCGGATGTTTCTCACCTCATTATCAATCATCACCTTAGTCGGATTTGGCCTC
GCATGGATGGTCAATATTCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MRIMRILVVEDDLILSHHLKVQLSDLGNQVQVALTAKEGFFQATNYPIDVAIVDLGLPDQDGISLIQQLREEGVKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVITSGELKLDLAAKQVTLANEVMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN

Sequences:

>Translated_227_residues
MRIMRILVVEDDLILSHHLKVQLSDLGNQVQVALTAKEGFFQATNYPIDVAIVDLGLPDQDGISLIQQLREEGVKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVITSGELKLDLAAKQVTLANEVMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
>Mature_227_residues
MRIMRILVVEDDLILSHHLKVQLSDLGNQVQVALTAKEGFFQATNYPIDVAIVDLGLPDQDGISLIQQLREEGVKAPILI
LTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVRRSAGFVKPVITSGELKLDLAAKQVTLANEVMEVTAFEYLI
LEYLMRHCHEVVAKQRLLDVIYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=49.5495495495495, Blast_Score=214, Evalue=4e-57,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.4615384615385, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=38.6363636363636, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=34.8214285714286, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=35.4260089686099, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=34.2105263157895, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=32.7272727272727, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.7837837837838, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=31.7180616740088, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=31.063829787234, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.0178571428571, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=27.8026905829596, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=29.3577981651376, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.4957264957265, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25490; Mature: 25490

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIMRILVVEDDLILSHHLKVQLSDLGNQVQVALTAKEGFFQATNYPIDVAIVDLGLPDQ
CCEEEEEEECCCEEEHHHEEEEECCCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCC
DGISLIQQLREEGVKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVR
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
RSAGFVKPVITSGELKLDLAAKQVTLANEVMEVTAFEYLILEYLMRHCHEVVAKQRLLDV
HCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
>Mature Secondary Structure
MRIMRILVVEDDLILSHHLKVQLSDLGNQVQVALTAKEGFFQATNYPIDVAIVDLGLPDQ
CCEEEEEEECCCEEEHHHEEEEECCCCCEEEEEEEECCCCEECCCCCEEEEEEEECCCCC
DGISLIQQLREEGVKAPILILTARVNWQDKVEGLNAGADDYLVKPFQKEELVARLDALVR
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
RSAGFVKPVITSGELKLDLAAKQVTLANEVMEVTAFEYLILEYLMRHCHEVVAKQRLLDV
HCCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYGDKEGDPNTIEVMVSRLRKKLTRDGIDNPIVTIRGQGYKFNLPCN
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA