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The map label for this gene is phoQ [H]

Identifier: 117920170

GI number: 117920170

Start: 2026085

End: 2027434

Strand: Reverse

Name: phoQ [H]

Synonym: Shewana3_1723

Alternate gene names: 117920170

Gene position: 2027434-2026085 (Counterclockwise)

Preceding gene: 117920171

Following gene: 117920168

Centisome position: 40.78

GC content: 48.81

Gene sequence:

>1350_bases
ATGCAATTAAGACTCAAAATGAAGAAACGTCTGCTCACGCGGATGTTTCTCACCTCATTATCAATCATCACCTTAGTCGG
ATTTGGCCTCGCATGGATGGTCAATATTCTGCATGCGCAAAATAGCTACAACGAAGAAACTGCGCAGCTGATCGCCGAGA
TCCCCCAAGTCGCCGCCGAGTTGAGGGAACATGACTTGATCCCCGACACCAGCGCTTGGTTGGAGGAAAATAACAAGCAA
GAACGCTATGTGATGGCGAGCTGCGATGAAAAATTTAAGCAAGTGTGGACATCTTCCCTCGCAGTTGACCGAGGATTGTT
TGATACCTGCGAGCGTTTCAACGAAATCCGTAATGACTCCCCGCCCTACTACCTAACTATGGCCGATGACAGAGGCTACT
TTGTGTATTTACTCGCTGTCGAAATCGCGGGAGTACATTACAACCTGCTGGTGATGAAGGATGCCGCCAAACTCGAGCAG
GAATACAGCAAATTCAGTAAACGCACCTATATACGTTTAGCCATGGTGCTCGCCCTCGCGCTCATTCTGCTGGTCAGTGC
GGCTTATTGGGGGATGCGTCCGTTGGTACGGATGCAAAATGAACTGCAATCGATTAACCAAGGTAAGACGAAATCGCTTT
CAGAGGGTTACCCTGTTGAGCTTGAAGGGGTTACTCAAGCCCTTAACCAACTCTTACAACAATCAAGCGCGCAACAGCAA
CGCTATCAAAATGCGATGAACGATCTGGCCCACAGCCTAAAAACCCGTCTTGCCGCCGTTCATGCCATTACCGATGACAC
GAGTCTCAGTAAACAATCTGCCAATGAAAAAATCATGGAGCAGATCAGCCAAATGGATCAACTGGTTAAATATCAACTTA
AACGTGCCATGTTGGGTCGCCAAGGCTTAAAGCAGGAACACACCGCCATCGCCCCGCTCGTCGACCAACTCGCGCAAATG
TTGTTTAAAATTTATCGCGAAAAACAGGTGCAATTTAAGGCTAACATTCCCACAAACCTGCAGTTTCCGGGCAATAAGGG
CGACTTGATGGAGCTATGTGGCAACCTGATGGAAAATGCCTTCCGTTTGTGTATCAGCCAAGTTCAGGTCAGCGCCCGCT
ATACAGATCAAGGTGATTTTGAATTAATCGTCGAAGATGACGGACCTGGGGTTGAAGAGAAGCTGCGCCAAAAAATCATT
CAACGGGGCGTGAGAGCCGACACCCAATCTCCAGGCCAAGGTATTGGCTTAGCCGTATGTGATGAGATTGTCAGCAGTTA
TGGCGGCGAACTCAGCATTGAAGAAAGCCATTTAGAGGGCGCGCGCTTTCGCATTCGCATCCCCGTCTAA

Upstream 100 bases:

>100_bases
TTGAGGTTATGGTGAGCCGTCTACGTAAAAAACTCACCCGCGACGGCATAGACAACCCTATTGTGACCATCCGTGGCCAA
GGTTATAAATTCAATCTGCC

Downstream 100 bases:

>100_bases
ATAATTCCTAGAATTTTATGCATATACCGCGTATAACTGCTCGGCGCGGTTAAACATTACCCATGACGTGGCAATATATT
TATCGTTACTGATCGGCATA

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQLRLKMKKRLLTRMFLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVMASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIAGVHYNLLVMKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKTKSLSEGYPVELEGVTQALNQLLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDTSLSKQSANEKIMEQISQMDQLVKYQLKRAMLGRQGLKQEHTAIAPLVDQLAQM
LFKIYREKQVQFKANIPTNLQFPGNKGDLMELCGNLMENAFRLCISQVQVSARYTDQGDFELIVEDDGPGVEEKLRQKII
QRGVRADTQSPGQGIGLAVCDEIVSSYGGELSIEESHLEGARFRIRIPV

Sequences:

>Translated_449_residues
MQLRLKMKKRLLTRMFLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVMASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIAGVHYNLLVMKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKTKSLSEGYPVELEGVTQALNQLLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDTSLSKQSANEKIMEQISQMDQLVKYQLKRAMLGRQGLKQEHTAIAPLVDQLAQM
LFKIYREKQVQFKANIPTNLQFPGNKGDLMELCGNLMENAFRLCISQVQVSARYTDQGDFELIVEDDGPGVEEKLRQKII
QRGVRADTQSPGQGIGLAVCDEIVSSYGGELSIEESHLEGARFRIRIPV
>Mature_449_residues
MQLRLKMKKRLLTRMFLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAELREHDLIPDTSAWLEENNKQ
ERYVMASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDSPPYYLTMADDRGYFVYLLAVEIAGVHYNLLVMKDAAKLEQ
EYSKFSKRTYIRLAMVLALALILLVSAAYWGMRPLVRMQNELQSINQGKTKSLSEGYPVELEGVTQALNQLLQQSSAQQQ
RYQNAMNDLAHSLKTRLAAVHAITDDTSLSKQSANEKIMEQISQMDQLVKYQLKRAMLGRQGLKQEHTAIAPLVDQLAQM
LFKIYREKQVQFKANIPTNLQFPGNKGDLMELCGNLMENAFRLCISQVQVSARYTDQGDFELIVEDDGPGVEEKLRQKII
QRGVRADTQSPGQGIGLAVCDEIVSSYGGELSIEESHLEGARFRIRIPV

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=294, Percent_Identity=35.7142857142857, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=25.6198347107438, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=295, Percent_Identity=28.135593220339, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=282, Percent_Identity=24.822695035461, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=28.6290322580645, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=23.3576642335766, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786837, Length=145, Percent_Identity=33.7931034482759, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786600, Length=256, Percent_Identity=24.609375, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=279, Percent_Identity=24.0143369175627, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50982; Mature: 50982

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLKMKKRLLTRMFLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSAWLEENNKQERYVMASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDS
HHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PPYYLTMADDRGYFVYLLAVEIAGVHYNLLVMKDAAKLEQEYSKFSKRTYIRLAMVLALA
CCEEEEEECCCCCEEEEEEHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLVSAAYWGMRPLVRMQNELQSINQGKTKSLSEGYPVELEGVTQALNQLLQQSSAQQQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RYQNAMNDLAHSLKTRLAAVHAITDDTSLSKQSANEKIMEQISQMDQLVKYQLKRAMLGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLKQEHTAIAPLVDQLAQMLFKIYREKQVQFKANIPTNLQFPGNKGDLMELCGNLMENA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
FRLCISQVQVSARYTDQGDFELIVEDDGPGVEEKLRQKIIQRGVRADTQSPGQGIGLAVC
HHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DEIVSSYGGELSIEESHLEGARFRIRIPV
HHHHHHCCCCEEEEHHHCCCCEEEEECCC
>Mature Secondary Structure
MQLRLKMKKRLLTRMFLTSLSIITLVGFGLAWMVNILHAQNSYNEETAQLIAEIPQVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LREHDLIPDTSAWLEENNKQERYVMASCDEKFKQVWTSSLAVDRGLFDTCERFNEIRNDS
HHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PPYYLTMADDRGYFVYLLAVEIAGVHYNLLVMKDAAKLEQEYSKFSKRTYIRLAMVLALA
CCEEEEEECCCCCEEEEEEHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLVSAAYWGMRPLVRMQNELQSINQGKTKSLSEGYPVELEGVTQALNQLLQQSSAQQQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
RYQNAMNDLAHSLKTRLAAVHAITDDTSLSKQSANEKIMEQISQMDQLVKYQLKRAMLGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLKQEHTAIAPLVDQLAQMLFKIYREKQVQFKANIPTNLQFPGNKGDLMELCGNLMENA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
FRLCISQVQVSARYTDQGDFELIVEDDGPGVEEKLRQKIIQRGVRADTQSPGQGIGLAVC
HHHHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
DEIVSSYGGELSIEESHLEGARFRIRIPV
HHHHHHCCCCEEEEHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA