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The map label for this gene is adhc1 [H]

Identifier: 117920141

GI number: 117920141

Start: 1992984

End: 1994030

Strand: Direct

Name: adhc1 [H]

Synonym: Shewana3_1694

Alternate gene names: 117920141

Gene position: 1992984-1994030 (Clockwise)

Preceding gene: 117920140

Following gene: 117920142

Centisome position: 40.08

GC content: 51.67

Gene sequence:

>1047_bases
ATGCAAACCATTGGATATGCCGCAGCATCGGCGCAAAGCCCGCTAGAACCTTATCACTATGAGTGCCGTGAATTACGGGA
CAACGATGTCGCTATCGAAATTCTCTATAGCGGCGTCTGTCATAGCGATTTACATACAGTGAAAAACGATTGGGGCTGGA
CGGTTTATCCTACTGTACCAGGCCATGAAATCGTTGGCCGCGTGGTGCAAGTGGGCAGCCAAGTGAACAAATACAAGGTG
GGCGATCATGTCGCTGTGGGCTGTATGGTCGACAGCTGTCAGGAATGTACTCACTGTCATCACGGTGAAGAGCAATTCTG
TGAGCAGGGTTTTACCCAAACCTACAACAGTGCCGATAGGCAAACCCAAGAGCTTACCAAGGGCGGCTATGCCAAGCATA
TCGTAGTGCGCCAAGAGTTTGTGCTGAGTATTCCGACATCGCTCGACCTTGCTAAAGTCGCGCCCTTACTCTGTGCGGGG
ATCACCACCTATTCGCCCTTAAGAACTTGGAACGTTGGGCCTGGCAGTCAAGTTGCTGTTATTGGTATGGGCGGTTTAGG
CCATATGGCGATCAAACTTGCGGCCGCGATGGGCGCCCATGTGACTGTACTGAGCCGCTCGGAAAGTAAGCGCAGCGATG
CGCTCGAACTGGGTGCGAGTGACTTTTTGATCTCTTCAGATCTTGAGCGCATGCAGCAAGCCGCCAATCGCTTCGAGCTT
ATCATCGATACAGTGCCAACAAAGCATGACATTACCCCGTACCTGCCATTATTGAATGTGGATGGCACGCTCACCTTAGT
CGGTCAAGTGGGGCCGATTGCTGAAGTAAATACTGTGCCTATGGTGATGGGACGTCGCCGTATTGCCGCCTCACTCATTG
GTGGCATTGCCGAGACTCAGGAGATGCTCGATTTCTGCGGCCGGATGAACATTTTGCCTGAGGTCGAGATGATCAAAATG
GAGCAGATTAATGAAGCCTTCGAGCGGTTGGAAAAATCCGACGTGCATTACCGATTTGTGATCGATATGCAGGCCTCTTC
CTTCTAG

Upstream 100 bases:

>100_bases
CTGTAATTTAGCTCATGGGCCAGCGCTTTTGCTGGCCTTGATTCGTTTTCGCAGAAGCGTGTCATTTTACGTTTCTGCCT
CAATCCACAGGGGATGAAAT

Downstream 100 bases:

>100_bases
GCTTAAGAAGGTTATTTCATTTGTTAAAAGGACGGTTTGCGGATCATTCCCCATGCCGCCATCACTTTTAAAAATCAGTT
TAAGACAACGTCAGTAAAGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MQTIGYAAASAQSPLEPYHYECRELRDNDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVQVGSQVNKYKV
GDHVAVGCMVDSCQECTHCHHGEEQFCEQGFTQTYNSADRQTQELTKGGYAKHIVVRQEFVLSIPTSLDLAKVAPLLCAG
ITTYSPLRTWNVGPGSQVAVIGMGGLGHMAIKLAAAMGAHVTVLSRSESKRSDALELGASDFLISSDLERMQQAANRFEL
IIDTVPTKHDITPYLPLLNVDGTLTLVGQVGPIAEVNTVPMVMGRRRIAASLIGGIAETQEMLDFCGRMNILPEVEMIKM
EQINEAFERLEKSDVHYRFVIDMQASSF

Sequences:

>Translated_348_residues
MQTIGYAAASAQSPLEPYHYECRELRDNDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVQVGSQVNKYKV
GDHVAVGCMVDSCQECTHCHHGEEQFCEQGFTQTYNSADRQTQELTKGGYAKHIVVRQEFVLSIPTSLDLAKVAPLLCAG
ITTYSPLRTWNVGPGSQVAVIGMGGLGHMAIKLAAAMGAHVTVLSRSESKRSDALELGASDFLISSDLERMQQAANRFEL
IIDTVPTKHDITPYLPLLNVDGTLTLVGQVGPIAEVNTVPMVMGRRRIAASLIGGIAETQEMLDFCGRMNILPEVEMIKM
EQINEAFERLEKSDVHYRFVIDMQASSF
>Mature_348_residues
MQTIGYAAASAQSPLEPYHYECRELRDNDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVPGHEIVGRVVQVGSQVNKYKV
GDHVAVGCMVDSCQECTHCHHGEEQFCEQGFTQTYNSADRQTQELTKGGYAKHIVVRQEFVLSIPTSLDLAKVAPLLCAG
ITTYSPLRTWNVGPGSQVAVIGMGGLGHMAIKLAAAMGAHVTVLSRSESKRSDALELGASDFLISSDLERMQQAANRFEL
IIDTVPTKHDITPYLPLLNVDGTLTLVGQVGPIAEVNTVPMVMGRRRIAASLIGGIAETQEMLDFCGRMNILPEVEMIKM
EQINEAFERLEKSDVHYRFVIDMQASSF

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=25.0681198910082, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=25.0681198910082, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=25.6267409470752, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=25.2840909090909, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71565154, Length=245, Percent_Identity=29.3877551020408, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI71743840, Length=229, Percent_Identity=26.6375545851528, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI262073058, Length=229, Percent_Identity=26.6375545851528, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI71565152, Length=244, Percent_Identity=26.6393442622951, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=344, Percent_Identity=52.9069767441861, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI87082401, Length=338, Percent_Identity=36.3905325443787, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI87081918, Length=327, Percent_Identity=26.2996941896024, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI226510992, Length=254, Percent_Identity=29.5275590551181, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=255, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788073, Length=268, Percent_Identity=26.4925373134328, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=259, Percent_Identity=27.4131274131274, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786552, Length=245, Percent_Identity=28.9795918367347, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790045, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082125, Length=180, Percent_Identity=27.7777777777778, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=26.6862170087977, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=28.2352941176471, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=28.6549707602339, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=360, Percent_Identity=26.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=26.3586956521739, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=334, Percent_Identity=26.6467065868263, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=24.7159090909091, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=35.3658536585366, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319949, Length=347, Percent_Identity=32.2766570605187, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=32.3262839879154, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=32.6153846153846, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=325, Percent_Identity=31.6923076923077, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=30.0911854103343, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=26.2872628726287, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=305, Percent_Identity=26.5573770491803, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=26.5193370165746, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17737897, Length=233, Percent_Identity=30.0429184549356, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137530, Length=232, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38256; Mature: 38256

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIGYAAASAQSPLEPYHYECRELRDNDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVP
CCCCCCCHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCC
GHEIVGRVVQVGSQVNKYKVGDHVAVGCMVDSCQECTHCHHGEEQFCEQGFTQTYNSADR
CHHHHHHHHHHCCCCCCEECCCCEEEHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCHHHH
QTQELTKGGYAKHIVVRQEFVLSIPTSLDLAKVAPLLCAGITTYSPLRTWNVGPGSQVAV
HHHHHHCCCCCEEEEEEHHHHEECCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCEEEE
IGMGGLGHMAIKLAAAMGAHVTVLSRSESKRSDALELGASDFLISSDLERMQQAANRFEL
EEECCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEE
IIDTVPTKHDITPYLPLLNVDGTLTLVGQVGPIAEVNTVPMVMGRRRIAASLIGGIAETQ
EEECCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EMLDFCGRMNILPEVEMIKMEQINEAFERLEKSDVHYRFVIDMQASSF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
>Mature Secondary Structure
MQTIGYAAASAQSPLEPYHYECRELRDNDVAIEILYSGVCHSDLHTVKNDWGWTVYPTVP
CCCCCCCHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCC
GHEIVGRVVQVGSQVNKYKVGDHVAVGCMVDSCQECTHCHHGEEQFCEQGFTQTYNSADR
CHHHHHHHHHHCCCCCCEECCCCEEEHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCHHHH
QTQELTKGGYAKHIVVRQEFVLSIPTSLDLAKVAPLLCAGITTYSPLRTWNVGPGSQVAV
HHHHHHCCCCCEEEEEEHHHHEECCCCCCHHHHHHHHHHCCCCCCCCEEECCCCCCEEEE
IGMGGLGHMAIKLAAAMGAHVTVLSRSESKRSDALELGASDFLISSDLERMQQAANRFEL
EEECCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEE
IIDTVPTKHDITPYLPLLNVDGTLTLVGQVGPIAEVNTVPMVMGRRRIAASLIGGIAETQ
EEECCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EMLDFCGRMNILPEVEMIKMEQINEAFERLEKSDVHYRFVIDMQASSF
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]