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The map label for this gene is tesB [H]

Identifier: 117920135

GI number: 117920135

Start: 1983137

End: 1984003

Strand: Direct

Name: tesB [H]

Synonym: Shewana3_1688

Alternate gene names: 117920135

Gene position: 1983137-1984003 (Clockwise)

Preceding gene: 117920134

Following gene: 117920136

Centisome position: 39.88

GC content: 50.87

Gene sequence:

>867_bases
ATGAGTCAGGTATTAGACGATCTCTTATCATTATTATCCCTCGAGCAAATTGAAATCGGGCTGTTTCGTGGTCAAAGCCA
AGACTTAGGATTTGGGCATGTGTTTGGTGGTCAAGTGATGGGGCAGGCCTTGAGCGCCGCTAAGCAAACCGTGCCAGCCG
AACGTAAAGTGCATTCGCTACACTCTTATTTTTTACGCGCAGGGGATGAGAAGCTCCCCATAGTCTATGAAGTGGAAAAT
ATGCGTGACGGCGGCAGTTTCAGTGCTAGACGCGTGAGCGCAATACAAAAGGGGCGGCCGATTTTTCATATGACCTGCTC
CTTCCAAGAACCCGAGGCGGGCTTTGACCATCAGGCCCAAATGCCTGAGGTGCCGGGCCCTGAAGGTTTATTGAATCAAA
ACGAGCTGGCGATGACCTTAAGGGATAAAGTGCCCGCGCGCATTCTCGAAAAGTTTATGGAAGACGCGCCGATTGAGATG
CGGTTAGTCAATCCTTTGCATCCCTTCGCGCCAAAAGAAACCGAACCCTATCGCTATGTGTGGCTAAGGGCGAATGGGCC
AATGCCAACGGATGCCCATATTCACGAGTATTTGCTGGCCTACGCCTCTGACTTTAACTTTTTAGTCACGGCGGCTCAGC
CCCATGGTGTGTCCTTTTTAACGCCGGGGATCCGCATGGCAACAATCGATCATGCGATGTGGTTCCATCGCCCAATTAAT
ATGGGAGAATGGTTGCTCTACAGTATCGACAGTCCAACCGCCAGCGGTGGACGAGGTTATGTACGAGGCCAATTTTTTAA
TCAGCAGGGTGAGCTTGTCGCCTCGACGACTCAAGAGGGGCTGATCCGTATGGTAAAAGGAAGTTAA

Upstream 100 bases:

>100_bases
AGAAGCCACAAGATGCAATAAGCTAACGACTCTCTACTGGTCAGCCCTAGTCTAACTGAGTTACCCTTGGGCATTAGTTG
CTAATTTTCAGTAGGATCCC

Downstream 100 bases:

>100_bases
TATGTTGATGAAAATAAAGTTGTTTATGTCATTTTTACTGGTGACATTTGCCTTAAGTGGCTGCGTGACGGTTCAACCCG
ATCCTCCGGTGGTGGTTAAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSQVLDDLLSLLSLEQIEIGLFRGQSQDLGFGHVFGGQVMGQALSAAKQTVPAERKVHSLHSYFLRAGDEKLPIVYEVEN
MRDGGSFSARRVSAIQKGRPIFHMTCSFQEPEAGFDHQAQMPEVPGPEGLLNQNELAMTLRDKVPARILEKFMEDAPIEM
RLVNPLHPFAPKETEPYRYVWLRANGPMPTDAHIHEYLLAYASDFNFLVTAAQPHGVSFLTPGIRMATIDHAMWFHRPIN
MGEWLLYSIDSPTASGGRGYVRGQFFNQQGELVASTTQEGLIRMVKGS

Sequences:

>Translated_288_residues
MSQVLDDLLSLLSLEQIEIGLFRGQSQDLGFGHVFGGQVMGQALSAAKQTVPAERKVHSLHSYFLRAGDEKLPIVYEVEN
MRDGGSFSARRVSAIQKGRPIFHMTCSFQEPEAGFDHQAQMPEVPGPEGLLNQNELAMTLRDKVPARILEKFMEDAPIEM
RLVNPLHPFAPKETEPYRYVWLRANGPMPTDAHIHEYLLAYASDFNFLVTAAQPHGVSFLTPGIRMATIDHAMWFHRPIN
MGEWLLYSIDSPTASGGRGYVRGQFFNQQGELVASTTQEGLIRMVKGS
>Mature_287_residues
SQVLDDLLSLLSLEQIEIGLFRGQSQDLGFGHVFGGQVMGQALSAAKQTVPAERKVHSLHSYFLRAGDEKLPIVYEVENM
RDGGSFSARRVSAIQKGRPIFHMTCSFQEPEAGFDHQAQMPEVPGPEGLLNQNELAMTLRDKVPARILEKFMEDAPIEMR
LVNPLHPFAPKETEPYRYVWLRANGPMPTDAHIHEYLLAYASDFNFLVTAAQPHGVSFLTPGIRMATIDHAMWFHRPINM
GEWLLYSIDSPTASGGRGYVRGQFFNQQGELVASTTQEGLIRMVKGS

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=289, Percent_Identity=41.1764705882353, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=61.13074204947, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71988741, Length=294, Percent_Identity=35.7142857142857, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17531889, Length=279, Percent_Identity=36.5591397849462, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI115532456, Length=279, Percent_Identity=36.5591397849462, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17531885, Length=279, Percent_Identity=36.5591397849462, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17558508, Length=309, Percent_Identity=35.5987055016181, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=272, Percent_Identity=31.6176470588235, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=277, Percent_Identity=29.2418772563177, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322480, Length=329, Percent_Identity=23.7082066869301, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32200; Mature: 32069

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVLDDLLSLLSLEQIEIGLFRGQSQDLGFGHVFGGQVMGQALSAAKQTVPAERKVHSL
CHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRAGDEKLPIVYEVENMRDGGSFSARRVSAIQKGRPIFHMTCSFQEPEAGFDHQAQ
HHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPEVPGPEGLLNQNELAMTLRDKVPARILEKFMEDAPIEMRLVNPLHPFAPKETEPYRYV
CCCCCCCCCCCCCCCEEEEHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEE
WLRANGPMPTDAHIHEYLLAYASDFNFLVTAAQPHGVSFLTPGIRMATIDHAMWFHRPIN
EEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEHHHHHHHCCCCC
MGEWLLYSIDSPTASGGRGYVRGQFFNQQGELVASTTQEGLIRMVKGS
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHEEECCC
>Mature Secondary Structure 
SQVLDDLLSLLSLEQIEIGLFRGQSQDLGFGHVFGGQVMGQALSAAKQTVPAERKVHSL
HHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHH
HSYFLRAGDEKLPIVYEVENMRDGGSFSARRVSAIQKGRPIFHMTCSFQEPEAGFDHQAQ
HHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCC
MPEVPGPEGLLNQNELAMTLRDKVPARILEKFMEDAPIEMRLVNPLHPFAPKETEPYRYV
CCCCCCCCCCCCCCCEEEEHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEE
WLRANGPMPTDAHIHEYLLAYASDFNFLVTAAQPHGVSFLTPGIRMATIDHAMWFHRPIN
EEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCEEEEEHHHHHHHCCCCC
MGEWLLYSIDSPTASGGRGYVRGQFFNQQGELVASTTQEGLIRMVKGS
CCCEEEEEECCCCCCCCCCEEEEEEECCCCCEEECCHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]