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The map label for this gene is trpE [H]

Identifier: 117919968

GI number: 117919968

Start: 1770319

End: 1772010

Strand: Reverse

Name: trpE [H]

Synonym: Shewana3_1520

Alternate gene names: 117919968

Gene position: 1772010-1770319 (Counterclockwise)

Preceding gene: 117919976

Following gene: 117919967

Centisome position: 35.64

GC content: 51.6

Gene sequence:

>1692_bases
ATGACCCTAAAGACATTTAATCAGGTTACCCAAGTTGATGGCGCGCATTTTGCCCCGTCTCAACAGACATTCGCACGTTC
GCATACGCTCAAGGCGACGCTGGCATATCATAGCGACCCACTGCGCCTGTACCAGCACATCACCCAAGATGTACCCCATA
CCATGTTGTTAGAATCGGCAGAAATCGACAGCAAGGAAAATCTTAAGAGCATGGTGATGACCCATGCGGCGCTGATGATC
CGCTGCGATGGCTATCGTTTACGCTTTAGCGCACTGAGTGACAATGGCGTCAGTTTACTCGCCCCCATCGAGCAATTTTT
TATTGCTCGTTCAAGCCAAACTCAATGCCAACGCGATGGCCACAACTTAGTGGTCACGCTGCAAAAGGACACTGAGCTTA
AGGATGAAGATGCCCGCTTAAAATCCACCTCGCCCCTCGATGGTTTGCGCTTGTTTGTAAAGCATATCGACTGCGGCCAG
ACGCCAGCATTCGAAGACTTATTTTTAGGTGGCGTGCTCTCCTACGATTTGATTGATACCGTCGAGCCACTGCCTGAAGC
ACCAAATGGTGCAAATGATTGTCCTGATTATTTATTTTATCTCGCCGAAACCTTAATTCTTATCGATCACAAGCAAAAAC
ACGCCGAGATCATCACTCACAACTTCAGTGAAGGCACTGAACAACATTTAGAGGTGACCCAAGCCTTAGCCGAGCGAGCA
GAGAACATCAGCGCCCAATGTGAAGCCCTAGCCAAGAGTGCAACACCTGCACCCGCCCTCGTCGGCATAACGGCCACAGA
GCAAGTGAATGTTAGTGATGATGACTTCAAGCAAACCGTTATTGATTTAAAAGAACACATTATTGCCGGCGACATCTTCC
AAGTCGTGCCTTCACGCAGCTTTAGCCTGCCCTGCCCCGATACCTTGGGAGCTTACCGCGCACTACGTTTAACCAACCCC
AGCCCCTATATGTTTTATTTCAGGGGCTATGACTTCACCCTGTTTGGCGCCTCGCCCGAGAGCGCGCTGAAATATGAAGC
CAGCAATAATCAGGTCGAAGTCTACCCGATTGCAGGCACCCGTAAACGCGGCAAAACCGCCAGCGGCGAGATCGATTTCG
ACCTCGATAGCCGTATCGAACTCGAATTGCGTTTGGATAAAAAAGAGCTCTCCGAACATTTAATGTTGGTCGATTTAGCC
CGTAACGATATCGCCCGTATCAGCCAAAGCGGCAGCCGCAAAGTGGCCGAGTTACTTAAAGTCGACCGTTATTCCCACGT
CATGCACTTAGTCAGCCGCGTCACAGGTCAACTACGCCAAGACTTAGATGCACTCCACGCCTATCAGGCCTGTATGAATA
TGGGCACGCTAGTTGGCGCCCCGAAAGTGCGCGCCTCTCAATTGGTGCGTCAAGCAGAAAAGACCCGCCGCGGCAGCTAC
GGCGGCGCTGTGGGTTACCTCAACGCCCTTGGGGATATGGACACCTGTATCGTTATCCGCTCCGCCTTTGTGAAAAACGG
CGTTGCCCATATCCAAGCGGGTGCTGGCGTGGTGTTTGATTCCGATCCGCAGAGTGAAGCCGATGAAACCCGCCAAAAGG
CGCAGGCTGTGATTTCGGCCATCAAGATGGGCGCAGGCTTGGATGAAAGCCAGCAAGCAACTGCGACCACTACGACTGAA
CAACAAAGATAA

Upstream 100 bases:

>100_bases
AAAGTAACAGAATCAACAAAAAAGCCCGCAGAAATGCGGGCTTTTTTGTTGGTGCGAAAAATGTCTGCAACGCGGTAAAC
GGATAAAAAGCGAGATAAGC

Downstream 100 bases:

>100_bases
GGAGCCCAAGATGAAACTCTATTTACTCGATAACTTCGACTCCTTTACCTACAACTTAGTCGACCAATTTAGAAGCCTTG
GCTGTGAAGTGGTGATCTAC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTLKTFNQVTQVDGAHFAPSQQTFARSHTLKATLAYHSDPLRLYQHITQDVPHTMLLESAEIDSKENLKSMVMTHAALMI
RCDGYRLRFSALSDNGVSLLAPIEQFFIARSSQTQCQRDGHNLVVTLQKDTELKDEDARLKSTSPLDGLRLFVKHIDCGQ
TPAFEDLFLGGVLSYDLIDTVEPLPEAPNGANDCPDYLFYLAETLILIDHKQKHAEIITHNFSEGTEQHLEVTQALAERA
ENISAQCEALAKSATPAPALVGITATEQVNVSDDDFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPDTLGAYRALRLTNP
SPYMFYFRGYDFTLFGASPESALKYEASNNQVEVYPIAGTRKRGKTASGEIDFDLDSRIELELRLDKKELSEHLMLVDLA
RNDIARISQSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVRASQLVRQAEKTRRGSY
GGAVGYLNALGDMDTCIVIRSAFVKNGVAHIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLDESQQATATTTTE
QQR

Sequences:

>Translated_563_residues
MTLKTFNQVTQVDGAHFAPSQQTFARSHTLKATLAYHSDPLRLYQHITQDVPHTMLLESAEIDSKENLKSMVMTHAALMI
RCDGYRLRFSALSDNGVSLLAPIEQFFIARSSQTQCQRDGHNLVVTLQKDTELKDEDARLKSTSPLDGLRLFVKHIDCGQ
TPAFEDLFLGGVLSYDLIDTVEPLPEAPNGANDCPDYLFYLAETLILIDHKQKHAEIITHNFSEGTEQHLEVTQALAERA
ENISAQCEALAKSATPAPALVGITATEQVNVSDDDFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPDTLGAYRALRLTNP
SPYMFYFRGYDFTLFGASPESALKYEASNNQVEVYPIAGTRKRGKTASGEIDFDLDSRIELELRLDKKELSEHLMLVDLA
RNDIARISQSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVRASQLVRQAEKTRRGSY
GGAVGYLNALGDMDTCIVIRSAFVKNGVAHIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLDESQQATATTTTE
QQR
>Mature_562_residues
TLKTFNQVTQVDGAHFAPSQQTFARSHTLKATLAYHSDPLRLYQHITQDVPHTMLLESAEIDSKENLKSMVMTHAALMIR
CDGYRLRFSALSDNGVSLLAPIEQFFIARSSQTQCQRDGHNLVVTLQKDTELKDEDARLKSTSPLDGLRLFVKHIDCGQT
PAFEDLFLGGVLSYDLIDTVEPLPEAPNGANDCPDYLFYLAETLILIDHKQKHAEIITHNFSEGTEQHLEVTQALAERAE
NISAQCEALAKSATPAPALVGITATEQVNVSDDDFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPDTLGAYRALRLTNPS
PYMFYFRGYDFTLFGASPESALKYEASNNQVEVYPIAGTRKRGKTASGEIDFDLDSRIELELRLDKKELSEHLMLVDLAR
NDIARISQSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVRASQLVRQAEKTRRGSYG
GAVGYLNALGDMDTCIVIRSAFVKNGVAHIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLDESQQATATTTTEQ
QR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=507, Percent_Identity=54.2406311637081, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1788114, Length=488, Percent_Identity=28.4836065573771, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082077, Length=301, Percent_Identity=27.2425249169435, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320935, Length=445, Percent_Identity=35.9550561797753, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6324361, Length=394, Percent_Identity=24.3654822335025, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 62124; Mature: 61993

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKTFNQVTQVDGAHFAPSQQTFARSHTLKATLAYHSDPLRLYQHITQDVPHTMLLESA
CCCCHHHHHHHCCCCCCCCCHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCHHHHHHCC
EIDSKENLKSMVMTHAALMIRCDGYRLRFSALSDNGVSLLAPIEQFFIARSSQTQCQRDG
CCCCHHHHHHHHHHHHHHEEEECCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCC
HNLVVTLQKDTELKDEDARLKSTSPLDGLRLFVKHIDCGQTPAFEDLFLGGVLSYDLIDT
CEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VEPLPEAPNGANDCPDYLFYLAETLILIDHKQKHAEIITHNFSEGTEQHLEVTQALAERA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ENISAQCEALAKSATPAPALVGITATEQVNVSDDDFKQTVIDLKEHIIAGDIFQVVPSRS
HCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSLPCPDTLGAYRALRLTNPSPYMFYFRGYDFTLFGASPESALKYEASNNQVEVYPIAGT
CCCCCCHHHHHHEEEEECCCCCEEEEEECCEEEEECCCCCHHEEEECCCCEEEEEECCCC
RKRGKTASGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLK
CCCCCCCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVRASQLVRQAEKTRRGSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCC
GGAVGYLNALGDMDTCIVIRSAFVKNGVAHIQAGAGVVFDSDPQSEADETRQKAQAVISA
CCHHHHHHHHCCCHHHHHHHHHHHHCCHHEEECCCCEEECCCCCCHHHHHHHHHHHHHHH
IKMGAGLDESQQATATTTTEQQR
HHHCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
TLKTFNQVTQVDGAHFAPSQQTFARSHTLKATLAYHSDPLRLYQHITQDVPHTMLLESA
CCCHHHHHHHCCCCCCCCCHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCHHHHHHCC
EIDSKENLKSMVMTHAALMIRCDGYRLRFSALSDNGVSLLAPIEQFFIARSSQTQCQRDG
CCCCHHHHHHHHHHHHHHEEEECCEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCC
HNLVVTLQKDTELKDEDARLKSTSPLDGLRLFVKHIDCGQTPAFEDLFLGGVLSYDLIDT
CEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
VEPLPEAPNGANDCPDYLFYLAETLILIDHKQKHAEIITHNFSEGTEQHLEVTQALAERA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ENISAQCEALAKSATPAPALVGITATEQVNVSDDDFKQTVIDLKEHIIAGDIFQVVPSRS
HCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
FSLPCPDTLGAYRALRLTNPSPYMFYFRGYDFTLFGASPESALKYEASNNQVEVYPIAGT
CCCCCCHHHHHHEEEEECCCCCEEEEEECCEEEEECCCCCHHEEEECCCCEEEEEECCCC
RKRGKTASGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLK
CCCCCCCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVRASQLVRQAEKTRRGSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHCCCC
GGAVGYLNALGDMDTCIVIRSAFVKNGVAHIQAGAGVVFDSDPQSEADETRQKAQAVISA
CCHHHHHHHHCCCHHHHHHHHHHHHCCHHEEECCCCEEECCCCCCHHHHHHHHHHHHHHH
IKMGAGLDESQQATATTTTEQQR
HHHCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1773058; 12620739 [H]