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The map label for this gene is mazG [H]

Identifier: 117919563

GI number: 117919563

Start: 1312902

End: 1313780

Strand: Direct

Name: mazG [H]

Synonym: Shewana3_1114

Alternate gene names: 117919563

Gene position: 1312902-1313780 (Clockwise)

Preceding gene: 117919562

Following gene: 117919564

Centisome position: 26.4

GC content: 48.24

Gene sequence:

>879_bases
ATGACTTCCCATATCACGCCTTCTATTACTGAGCTTCCCGCAACAGCACTTTCTGCAACCGATGTTGCGCCGCTACTGAA
GATTATGGAGAAGCTGCGCGATCCGCAAACGGGTTGCCCATGGGATAAAGCCCAGACTTATCAAACCATAGTGCCTTTTA
CCCTCGAAGAGGCCTATGAGGTGGCTGACACGATTGAACGTTTAGCCTTAGACGAATTACCTGATGAGCTGGGGGATTTA
TTATTCCAAGTGGTGTTTTATTGCCAGCTTGGCAAAGAGCAGGGCAGGTTCGATTTCAGCACTGTCGTTAATAAAATCAC
CGACAAACTGACCCGCCGTCATCCCCATGTGTTTGGTAATGAAGTATTCGAGGCCGATGCCAGTAGTCAGCAGATGAAGG
CCAATTGGGAAGCAATCAAAGCCAGCGAGCGTGAACAAAAGGCATTGGCGGCTGGGGGGGCTTCATTAAGCGAGGTTTCT
GTGCTTGATGATATTCCGCGCGCGCAGCCAGCGTTATCCCGTTCAATCAAAATTCAGCAACGGGTCGCGCGCGTTGGGTT
CGATTGGCCTGAGCTTGAGCCTGTTGTCGCAAAAATCCATGAAGAAATTGATGAAGTGTTTGCGGAGGTGAATCAGCCAA
CGCTCGACCAAGCCAAAGTGCAGGCCGAAATGGGCGACTTATTATTTGCAGTGGTGAATTTGGCGCGCCATTTAAAGGTG
GACCCAGAACAAGCGCTGCGCCAAGCCAATGTTAAATTTGAACGCCGTTTTAAAGGTGTTGAGGCATTTGCAAGACAAAA
TAATAAAGCATTAGAAGAACATAGCTTAGAAGAGTTAGATGTCTATTGGGATAAGGTTAAACAGGGCGAGTCAAGATAA

Upstream 100 bases:

>100_bases
GCTTTATTGCCCTTATTACAGCCTTAGTTGCGACTCAGCTTGAGTGTATTCCTGTTTACGCATCCTGCACCTGTGTCGAC
TCTCTTGAAAGGATATCTGC

Downstream 100 bases:

>100_bases
AGGGCAAATTATCCGGATTGGTGTTTGTCGAATGGCAACACCTTTGGTATACTACTGCCCCGTCCTAGTGCTTTCTTACA
AGCACGTATTTTCAAACTCA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTSHITPSITELPATALSATDVAPLLKIMEKLRDPQTGCPWDKAQTYQTIVPFTLEEAYEVADTIERLALDELPDELGDL
LFQVVFYCQLGKEQGRFDFSTVVNKITDKLTRRHPHVFGNEVFEADASSQQMKANWEAIKASEREQKALAAGGASLSEVS
VLDDIPRAQPALSRSIKIQQRVARVGFDWPELEPVVAKIHEEIDEVFAEVNQPTLDQAKVQAEMGDLLFAVVNLARHLKV
DPEQALRQANVKFERRFKGVEAFARQNNKALEEHSLEELDVYWDKVKQGESR

Sequences:

>Translated_292_residues
MTSHITPSITELPATALSATDVAPLLKIMEKLRDPQTGCPWDKAQTYQTIVPFTLEEAYEVADTIERLALDELPDELGDL
LFQVVFYCQLGKEQGRFDFSTVVNKITDKLTRRHPHVFGNEVFEADASSQQMKANWEAIKASEREQKALAAGGASLSEVS
VLDDIPRAQPALSRSIKIQQRVARVGFDWPELEPVVAKIHEEIDEVFAEVNQPTLDQAKVQAEMGDLLFAVVNLARHLKV
DPEQALRQANVKFERRFKGVEAFARQNNKALEEHSLEELDVYWDKVKQGESR
>Mature_291_residues
TSHITPSITELPATALSATDVAPLLKIMEKLRDPQTGCPWDKAQTYQTIVPFTLEEAYEVADTIERLALDELPDELGDLL
FQVVFYCQLGKEQGRFDFSTVVNKITDKLTRRHPHVFGNEVFEADASSQQMKANWEAIKASEREQKALAAGGASLSEVSV
LDDIPRAQPALSRSIKIQQRVARVGFDWPELEPVVAKIHEEIDEVFAEVNQPTLDQAKVQAEMGDLLFAVVNLARHLKVD
PEQALRQANVKFERRFKGVEAFARQNNKALEEHSLEELDVYWDKVKQGESR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=266, Percent_Identity=54.5112781954887, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 32927; Mature: 32795

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHITPSITELPATALSATDVAPLLKIMEKLRDPQTGCPWDKAQTYQTIVPFTLEEAYE
CCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
VADTIERLALDELPDELGDLLFQVVFYCQLGKEQGRFDFSTVVNKITDKLTRRHPHVFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EVFEADASSQQMKANWEAIKASEREQKALAAGGASLSEVSVLDDIPRAQPALSRSIKIQQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
RVARVGFDWPELEPVVAKIHEEIDEVFAEVNQPTLDQAKVQAEMGDLLFAVVNLARHLKV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPEQALRQANVKFERRFKGVEAFARQNNKALEEHSLEELDVYWDKVKQGESR
CHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSHITPSITELPATALSATDVAPLLKIMEKLRDPQTGCPWDKAQTYQTIVPFTLEEAYE
CCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHH
VADTIERLALDELPDELGDLLFQVVFYCQLGKEQGRFDFSTVVNKITDKLTRRHPHVFGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EVFEADASSQQMKANWEAIKASEREQKALAAGGASLSEVSVLDDIPRAQPALSRSIKIQQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
RVARVGFDWPELEPVVAKIHEEIDEVFAEVNQPTLDQAKVQAEMGDLLFAVVNLARHLKV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPEQALRQANVKFERRFKGVEAFARQNNKALEEHSLEELDVYWDKVKQGESR
CHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]