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The map label for this gene is phoQ [H]

Identifier: 117919067

GI number: 117919067

Start: 719821

End: 721149

Strand: Reverse

Name: phoQ [H]

Synonym: Shewana3_0614

Alternate gene names: 117919067

Gene position: 721149-719821 (Counterclockwise)

Preceding gene: 117919068

Following gene: 117919042

Centisome position: 14.5

GC content: 50.41

Gene sequence:

>1329_bases
ATGATCTCCATTCGCACTAAGCTCAGTTTATGGTTAACGGGCTTATTAGTGTTAGGCACAGTGATTGGACTCATATTGTT
TGAGTCCATGCTGCGCCAAGCGTTTCACGACTCCATTATCAACCGCTTAGAAGAAGATCTTGAGCACATCATGTTGGCGA
CCCATATCAACAATGGGGAGATCCATATCGATCAGAGCCAACTGTCGAGCTTCTATCGCCCGGCCTATTCGGGGCGTTAT
TTCCAGCTCAACCTGCCTAATGAAGTGATCCGCTCCCGCTCCCTGTGGGACATGCAGCTCGATATCGAACCTTTAGCGCC
AAACCAGACCCGCGTCTGGCAGGCAAAAGGGCCGAAAAACAATGATATGCAGCTATTATCCCTAGGGCTAAACTCCAGCA
GCGCCAATGTCACCGCAACCCTAACGGTAGCGCAGGATTTGAGTATCGGCCGACGCGTGTTTAGTGAGGTCTATGGCACT
AAGCTTGGGATTAACCTCGCCATGTTGGTGGCTATGATCGCGGGGATATTCTTGATCCTGCGTCAATCCTTTAAACCGGT
AAAACAGATCCAACATGCACTCTCCCGTCTACAGGAGGGCGAGATTAACGCCTTAGAGCTGAATAACATTCCGCCCGAAG
TGCAACCGCTGGCTAAGACCTACAATGAGTTATTGGAATACACCGCCAAGCAAATTGAGCGCAGTCGCAATAACTTAGGC
AACTTAAGCCATGGGCTAAAAACCCCATTGGCGGTGATGCAGCAACAGGTTGAAGCCTTGGGGCTGAAAGATCCCGATAC
CGCCATGGCGCTGCAACAACAGCTCGACGCTATCCATAAAATGGTCGAGCGTAAACTTGCGGCGGCGCGGATCACCGGCG
ATATGTTACCTGCCGCCCAGTTAGTGGTACCGAGGGATCTTCACAGCCTCGCCAATACCCTCAACAAAGTGCATAGAAGC
AAAAGCATCGACTGCGACTTTGAGCTTGACCCTAGTATCCAGCGCCTGCCCATCCATAGGGAAGATGGTATGGAGCTCTT
AGGGAATCTGCTCGATAACGCCTTTAAATGGGCGGGCAGCCAAGTCACGGTAAAACTGTGGAAGGAACAAAACAAGCTCT
GCCTCAGTATAGATGATGATGGTCCAGGGGTTGCCGATGACGAACTCGATAAACTCACCCAAAGAGGCACGCGCCTCGAT
GAATCAGTTATGGGCCATGGCCTAGGGTTATCGATAGTGAAAGAAATTGCCGAGCAATATGGCATTGAGCTTAAGTTTAA
GCACAGCAGCCACTTATCAGGCCTCAGTATTGAACTGGTCTTTAGCTAA

Upstream 100 bases:

>100_bases
ACGTGGTTGAAGTTTACGTGACTCACCTGCGTAAAAAACTCGGCAAAACCGCGATTGAAACCCGCCGCGGCCAAGGTTAT
ATCTTCCACGGCCTGACTGC

Downstream 100 bases:

>100_bases
CGAGTGCTTAGCTAAGAGTGCTTAGCGAACAAGTATTGAGCTAACTATTTGCTCTGAGTGTTGCTCTAGTGCCACCAATA
AAAACGCCATCTATCGATGG

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MISIRTKLSLWLTGLLVLGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHINNGEIHIDQSQLSSFYRPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVTATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKQIQHALSRLQEGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPDTAMALQQQLDAIHKMVERKLAAARITGDMLPAAQLVVPRDLHSLANTLNKVHRS
KSIDCDFELDPSIQRLPIHREDGMELLGNLLDNAFKWAGSQVTVKLWKEQNKLCLSIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYGIELKFKHSSHLSGLSIELVFS

Sequences:

>Translated_442_residues
MISIRTKLSLWLTGLLVLGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHINNGEIHIDQSQLSSFYRPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVTATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKQIQHALSRLQEGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPDTAMALQQQLDAIHKMVERKLAAARITGDMLPAAQLVVPRDLHSLANTLNKVHRS
KSIDCDFELDPSIQRLPIHREDGMELLGNLLDNAFKWAGSQVTVKLWKEQNKLCLSIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYGIELKFKHSSHLSGLSIELVFS
>Mature_442_residues
MISIRTKLSLWLTGLLVLGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHINNGEIHIDQSQLSSFYRPAYSGRY
FQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKNNDMQLLSLGLNSSSANVTATLTVAQDLSIGRRVFSEVYGT
KLGINLAMLVAMIAGIFLILRQSFKPVKQIQHALSRLQEGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
NLSHGLKTPLAVMQQQVEALGLKDPDTAMALQQQLDAIHKMVERKLAAARITGDMLPAAQLVVPRDLHSLANTLNKVHRS
KSIDCDFELDPSIQRLPIHREDGMELLGNLLDNAFKWAGSQVTVKLWKEQNKLCLSIDDDGPGVADDELDKLTQRGTRLD
ESVMGHGLGLSIVKEIAEQYGIELKFKHSSHLSGLSIELVFS

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=309, Percent_Identity=27.1844660194175, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=26.6423357664234, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789808, Length=276, Percent_Identity=24.2753623188406, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=280, Percent_Identity=27.5, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=23.6111111111111, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788279, Length=318, Percent_Identity=25.1572327044025, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787894, Length=264, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=25.4716981132075, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49397; Mature: 49397

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIRTKLSLWLTGLLVLGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHINNGE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCE
IHIDQSQLSSFYRPAYSGRYFQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKN
EEEEHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCC
NDMQLLSLGLNSSSANVTATLTVAQDLSIGRRVFSEVYGTKLGINLAMLVAMIAGIFLIL
CCCEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQSFKPVKQIQHALSRLQEGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
HHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLSHGLKTPLAVMQQQVEALGLKDPDTAMALQQQLDAIHKMVERKLAAARITGDMLPAAQ
CHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVVPRDLHSLANTLNKVHRSKSIDCDFELDPSIQRLPIHREDGMELLGNLLDNAFKWAGS
HHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCC
QVTVKLWKEQNKLCLSIDDDGPGVADDELDKLTQRGTRLDESVMGHGLGLSIVKEIAEQY
CEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
GIELKFKHSSHLSGLSIELVFS
CCEEEEECCCCCCCCEEEEEEC
>Mature Secondary Structure
MISIRTKLSLWLTGLLVLGTVIGLILFESMLRQAFHDSIINRLEEDLEHIMLATHINNGE
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCE
IHIDQSQLSSFYRPAYSGRYFQLNLPNEVIRSRSLWDMQLDIEPLAPNQTRVWQAKGPKN
EEEEHHHHHHHHCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCC
NDMQLLSLGLNSSSANVTATLTVAQDLSIGRRVFSEVYGTKLGINLAMLVAMIAGIFLIL
CCCEEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQSFKPVKQIQHALSRLQEGEINALELNNIPPEVQPLAKTYNELLEYTAKQIERSRNNLG
HHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLSHGLKTPLAVMQQQVEALGLKDPDTAMALQQQLDAIHKMVERKLAAARITGDMLPAAQ
CHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LVVPRDLHSLANTLNKVHRSKSIDCDFELDPSIQRLPIHREDGMELLGNLLDNAFKWAGS
HHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCC
QVTVKLWKEQNKLCLSIDDDGPGVADDELDKLTQRGTRLDESVMGHGLGLSIVKEIAEQY
CEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHH
GIELKFKHSSHLSGLSIELVFS
CCEEEEECCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]