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The map label for this gene is phoP [H]

Identifier: 117919068

GI number: 117919068

Start: 721146

End: 721820

Strand: Reverse

Name: phoP [H]

Synonym: Shewana3_0615

Alternate gene names: 117919068

Gene position: 721820-721146 (Counterclockwise)

Preceding gene: 117919069

Following gene: 117919067

Centisome position: 14.52

GC content: 48.3

Gene sequence:

>675_bases
ATGAAACTGCTACTCGTTGAAGATAATCCGATGTTGGTCTCCGAACTGGAGAAACAACTCAAACAGGCTGGCTACGTTAC
CGATATTACTGACAAAGCACTTGAAGCCGATTACCTCGTTAAAGAAACCCAATATGACTGCGTGATCTTAGATATTGGCC
TCCCCGACGGCAATGGACTGGAATTACTCGAAGGTTGGCGTAATCAAGGCATTAGCACACCGGTTATTATGCTGACGGCT
CGCAGCCAATGGCATGAAAAGGTCGAAGGCTTTAATGCCGGCGCCGATGATTATTTGGGTAAACCCTTCCATGCACAGGA
ATTACTCGCGCGTATCCAGGCGCTTATTCACCGCGCGCACGGCCGATTAAATAATCCGAGTAAACAGTTGAGCTATGGCG
GTGTCACCTTAGACGAGGCCGAGCAGACAGTAAGCGTTGGTGAGCATTTATATGAGTTGACCGCCATGGAGTTCAGGCTG
TTAAAAATCTTCCTCATGTCGCCTAAGAAGCTGTTATCTAAGGCACAACTGACGGACAAGCTCTATCAGTTTGACGATGA
GAAAGAGAGTAACGTGGTTGAAGTTTACGTGACTCACCTGCGTAAAAAACTCGGCAAAACCGCGATTGAAACCCGCCGCG
GCCAAGGTTATATCTTCCACGGCCTGACTGCATGA

Upstream 100 bases:

>100_bases
CAAATCAAAGTGCAACGCGGCCAAATAGTGAATCTGAGTATTGATGCCACCAATGGTCAACTCGAACACTCCACCGCACT
ACCGAGCGAATGTCGAAAAC

Downstream 100 bases:

>100_bases
TCTCCATTCGCACTAAGCTCAGTTTATGGTTAACGGGCTTATTAGTGTTAGGCACAGTGATTGGACTCATATTGTTTGAG
TCCATGCTGCGCCAAGCGTT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKLLLVEDNPMLVSELEKQLKQAGYVTDITDKALEADYLVKETQYDCVILDIGLPDGNGLELLEGWRNQGISTPVIMLTA
RSQWHEKVEGFNAGADDYLGKPFHAQELLARIQALIHRAHGRLNNPSKQLSYGGVTLDEAEQTVSVGEHLYELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTA

Sequences:

>Translated_224_residues
MKLLLVEDNPMLVSELEKQLKQAGYVTDITDKALEADYLVKETQYDCVILDIGLPDGNGLELLEGWRNQGISTPVIMLTA
RSQWHEKVEGFNAGADDYLGKPFHAQELLARIQALIHRAHGRLNNPSKQLSYGGVTLDEAEQTVSVGEHLYELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTA
>Mature_224_residues
MKLLLVEDNPMLVSELEKQLKQAGYVTDITDKALEADYLVKETQYDCVILDIGLPDGNGLELLEGWRNQGISTPVIMLTA
RSQWHEKVEGFNAGADDYLGKPFHAQELLARIQALIHRAHGRLNNPSKQLSYGGVTLDEAEQTVSVGEHLYELTAMEFRL
LKIFLMSPKKLLSKAQLTDKLYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=39.0134529147982, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=37.4429223744292, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.5296803652968, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.4821428571429, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=33.1838565022422, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=34.5291479820628, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=179, Percent_Identity=37.9888268156425, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=30.8035714285714, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=30.3030303030303, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=29.2792792792793, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=31.7596566523605, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788394, Length=205, Percent_Identity=30.2439024390244, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.7359307359307, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25302; Mature: 25302

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLVEDNPMLVSELEKQLKQAGYVTDITDKALEADYLVKETQYDCVILDIGLPDGNGL
CEEEEECCCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCH
ELLEGWRNQGISTPVIMLTARSQWHEKVEGFNAGADDYLGKPFHAQELLARIQALIHRAH
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
GRLNNPSKQLSYGGVTLDEAEQTVSVGEHLYELTAMEFRLLKIFLMSPKKLLSKAQLTDK
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MKLLLVEDNPMLVSELEKQLKQAGYVTDITDKALEADYLVKETQYDCVILDIGLPDGNGL
CEEEEECCCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCH
ELLEGWRNQGISTPVIMLTARSQWHEKVEGFNAGADDYLGKPFHAQELLARIQALIHRAH
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHH
GRLNNPSKQLSYGGVTLDEAEQTVSVGEHLYELTAMEFRLLKIFLMSPKKLLSKAQLTDK
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LYQFDDEKESNVVEVYVTHLRKKLGKTAIETRRGQGYIFHGLTA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA