Click here to switch to the map view.

The map label for this gene is fabB [H]

Identifier: 117918783

GI number: 117918783

Start: 360461

End: 361714

Strand: Reverse

Name: fabB [H]

Synonym: Shewana3_0326

Alternate gene names: 117918783

Gene position: 361714-360461 (Counterclockwise)

Preceding gene: 117918784

Following gene: 117918782

Centisome position: 7.27

GC content: 54.63

Gene sequence:

>1254_bases
ATGACGCAGCGCAATCCCCTAGGCAGACGAGTCGTCGTTACTGGTATCGGTGGCATCAGTGCCCTAGGCCATGACTGGCC
GAGTATCGCAAGCAGCCTTAAGGCACAAAAAAACTGTGTCGTGACGATGGCGGAATGGGATAAATATGACGGGCTGAACA
CCCGCTTAGCTGCACCTATTACTGACTTTGAGGTGCCGAGCCACTATTCCCGCAAAAAGATCCGCTCCATGGGACGCGTC
TCGATTATGGCGACTCGCGCCAGCGAACTTGCGCTGATGGATGCTGGACTCTTGGACGATCCTATCGTCACCTCGGGGGA
AATGGGGATTGCCTATGGTTCTTCCACCGGCAGTACTGACCCGCTGGTCGCCTTTGGCGATATGCTCAAAAATGGCGATA
TGTCAGGCGTCACCGCCACCAGCTATATCCGCATGATGGCACACACCACTGCGGTAAACGTGGGGGTATTCTTTGGTCTT
AAGGGACGCATTCATACCACCAGCAGCGCCTGTACTTCGGGCAGCCAAGGCATAGGTTACGCCTATGAGGCCATCAAATA
CGGGCAACAGACCTTAATGCTCGCGGGCGGCGGTGAAGAACTCTGCCCGACCGAGGCCGTGGTATTCGACACCCTGTTTG
CCACCAGCACTAAAAATGCCACCCCTGAGTTAACGCCTCGCCCCTTCGATGCCCATCGCGACGGTTTAGTGATTGGTGAA
GGCGCTTGTACGCTGGTACTCGAAGAGTTAGAACACGCCATGGCGCGCGGCGCGAAAATTTACGCCGAGATCGTCGGTTT
TGGCACTAACTCCGATGGTCAGCATGTGACTCAGCCCAATAGCGATACCATGGAAATCGCCATTCGCTTAGCCCTTAAGG
ATGCGGCGCTCACGCCCGATGCCATTGGCTATGTAAATGCCCACGGCACAGCCACCGATCGTGGTGACGTTGCCGAAACC
CATGCAACGCATGCAGTATTTGGTGCGGATATGCCGATTTCATCCCTGAAAAGCTACACAGGCCATACCTTAGGTGCCTG
CGGCGCGTTAGAGGCATGGGTCAGTATCGAAATGATGAATGCGGGCTGGTTTGCCCCCACGCTTAATCTCGACAATATCG
ACCCAGAATGTGCCGCACTCGATTACATTCGCGGCGAGCCACGTACACTCGACACTGACTATGTGATGAGCAATAACTTC
GCCTTTGGCGGCATCAACACCTCACTGATTTTTAAACGCTGGAAAACGACATAA

Upstream 100 bases:

>100_bases
TAAACCGAATGAAATCGCCGCCTTAGCCGCTTTTTTAATGTCGGACGATGCTGCCTATATCACGCGCCAAGTGATTTCGG
TGAATGGAGGCATGATCTAA

Downstream 100 bases:

>100_bases
GGACATATCAATGAAACCATTAGTAGCAAGCATTTTACTCGGCATTAGCTTACTGGGCTCACCCGTATGGGCGCAGGAAT
ATACGGTTGAAACCTATCAA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTQRNPLGRRVVVTGIGGISALGHDWPSIASSLKAQKNCVVTMAEWDKYDGLNTRLAAPITDFEVPSHYSRKKIRSMGRV
SIMATRASELALMDAGLLDDPIVTSGEMGIAYGSSTGSTDPLVAFGDMLKNGDMSGVTATSYIRMMAHTTAVNVGVFFGL
KGRIHTTSSACTSGSQGIGYAYEAIKYGQQTLMLAGGGEELCPTEAVVFDTLFATSTKNATPELTPRPFDAHRDGLVIGE
GACTLVLEELEHAMARGAKIYAEIVGFGTNSDGQHVTQPNSDTMEIAIRLALKDAALTPDAIGYVNAHGTATDRGDVAET
HATHAVFGADMPISSLKSYTGHTLGACGALEAWVSIEMMNAGWFAPTLNLDNIDPECAALDYIRGEPRTLDTDYVMSNNF
AFGGINTSLIFKRWKTT

Sequences:

>Translated_417_residues
MTQRNPLGRRVVVTGIGGISALGHDWPSIASSLKAQKNCVVTMAEWDKYDGLNTRLAAPITDFEVPSHYSRKKIRSMGRV
SIMATRASELALMDAGLLDDPIVTSGEMGIAYGSSTGSTDPLVAFGDMLKNGDMSGVTATSYIRMMAHTTAVNVGVFFGL
KGRIHTTSSACTSGSQGIGYAYEAIKYGQQTLMLAGGGEELCPTEAVVFDTLFATSTKNATPELTPRPFDAHRDGLVIGE
GACTLVLEELEHAMARGAKIYAEIVGFGTNSDGQHVTQPNSDTMEIAIRLALKDAALTPDAIGYVNAHGTATDRGDVAET
HATHAVFGADMPISSLKSYTGHTLGACGALEAWVSIEMMNAGWFAPTLNLDNIDPECAALDYIRGEPRTLDTDYVMSNNF
AFGGINTSLIFKRWKTT
>Mature_416_residues
TQRNPLGRRVVVTGIGGISALGHDWPSIASSLKAQKNCVVTMAEWDKYDGLNTRLAAPITDFEVPSHYSRKKIRSMGRVS
IMATRASELALMDAGLLDDPIVTSGEMGIAYGSSTGSTDPLVAFGDMLKNGDMSGVTATSYIRMMAHTTAVNVGVFFGLK
GRIHTTSSACTSGSQGIGYAYEAIKYGQQTLMLAGGGEELCPTEAVVFDTLFATSTKNATPELTPRPFDAHRDGLVIGEG
ACTLVLEELEHAMARGAKIYAEIVGFGTNSDGQHVTQPNSDTMEIAIRLALKDAALTPDAIGYVNAHGTATDRGDVAETH
ATHAVFGADMPISSLKSYTGHTLGACGALEAWVSIEMMNAGWFAPTLNLDNIDPECAALDYIRGEPRTLDTDYVMSNNFA
FGGINTSLIFKRWKTT

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=35.0710900473934, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI41872631, Length=280, Percent_Identity=31.7857142857143, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223972627, Length=228, Percent_Identity=32.8947368421053, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=37.0731707317073, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=38.2566585956416, Blast_Score=224, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=31.4009661835749, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=36.7424242424242, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=347, Percent_Identity=27.3775216138329, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=265, Percent_Identity=26.4150943396226, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=32.2869955156951, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=34.4339622641509, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI19920632, Length=358, Percent_Identity=25.6983240223464, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330659, Length=358, Percent_Identity=25.6983240223464, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=25.4437869822485, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 44399; Mature: 44268

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRNPLGRRVVVTGIGGISALGHDWPSIASSLKAQKNCVVTMAEWDKYDGLNTRLAAPI
CCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCC
TDFEVPSHYSRKKIRSMGRVSIMATRASELALMDAGLLDDPIVTSGEMGIAYGSSTGSTD
CCCCCCCHHHHHHHHHCCCEEEEEECCHHHHEEECCCCCCCCCCCCCCEEEECCCCCCCC
PLVAFGDMLKNGDMSGVTATSYIRMMAHTTAVNVGVFFGLKGRIHTTSSACTSGSQGIGY
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCEEEECCHHCCCCCCCCHH
AYEAIKYGQQTLMLAGGGEELCPTEAVVFDTLFATSTKNATPELTPRPFDAHRDGLVIGE
HHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
GACTLVLEELEHAMARGAKIYAEIVGFGTNSDGQHVTQPNSDTMEIAIRLALKDAALTPD
CHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
AIGYVNAHGTATDRGDVAETHATHAVFGADMPISSLKSYTGHTLGACGALEAWVSIEMMN
CCEEEECCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHEEEEEEEC
AGWFAPTLNLDNIDPECAALDYIRGEPRTLDTDYVMSNNFAFGGINTSLIFKRWKTT
CCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCEEECCCCHHHEEEECCCC
>Mature Secondary Structure 
TQRNPLGRRVVVTGIGGISALGHDWPSIASSLKAQKNCVVTMAEWDKYDGLNTRLAAPI
CCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCC
TDFEVPSHYSRKKIRSMGRVSIMATRASELALMDAGLLDDPIVTSGEMGIAYGSSTGSTD
CCCCCCCHHHHHHHHHCCCEEEEEECCHHHHEEECCCCCCCCCCCCCCEEEECCCCCCCC
PLVAFGDMLKNGDMSGVTATSYIRMMAHTTAVNVGVFFGLKGRIHTTSSACTSGSQGIGY
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEEECCCEEEECCHHCCCCCCCCHH
AYEAIKYGQQTLMLAGGGEELCPTEAVVFDTLFATSTKNATPELTPRPFDAHRDGLVIGE
HHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
GACTLVLEELEHAMARGAKIYAEIVGFGTNSDGQHVTQPNSDTMEIAIRLALKDAALTPD
CHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
AIGYVNAHGTATDRGDVAETHATHAVFGADMPISSLKSYTGHTLGACGALEAWVSIEMMN
CCEEEECCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHHCCCCHHHHHHHHHEEEEEEEC
AGWFAPTLNLDNIDPECAALDYIRGEPRTLDTDYVMSNNFAFGGINTSLIFKRWKTT
CCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCEEECCCCHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]