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The map label for this gene is phoQ [H]

Identifier: 117918697

GI number: 117918697

Start: 273224

End: 274540

Strand: Reverse

Name: phoQ [H]

Synonym: Shewana3_0240

Alternate gene names: 117918697

Gene position: 274540-273224 (Counterclockwise)

Preceding gene: 117918698

Following gene: 117918691

Centisome position: 5.52

GC content: 49.35

Gene sequence:

>1317_bases
GTGTATTCACTCAAAGCCTATCTCACCCGCAATCTGCTTATCACCCTCACCTGTGCCATGGCGCTATTGTTGTATTTACT
GTTTCAAGGCATTCAAATCTTAACCCAAGACTTTGTTGCCTCGCGCCTACAACACGATGCCGATAGTCTGATCTCCGCCC
TCGAACCGCAAGCCGATGGCACTTGGTCACTGAGTGCCGATAGGCTCCCCAATGTGTATCACAGGGTCAATTCGGGCCAC
TACTTTGCGATTAACATCGGTGAACAGCTATTACGTTCACGCTCGCTGTTTGACCATGCCGTCTCACTCCCCAATCTTAA
CGTTGGCGAGCAACAACAAGTCACTCAATATGTTGGGCAGGAACACTGGCTGATGTTCAGCCAGACCATAGTCAAGAATG
GGCAAACCATTACCCTGTGGGTGACGGAAGACATAAGCTCGCTTGAGCAAACCCAATTACGCTTTTTAGGCTTTGCGGCG
GTAGTGGTACTGCTGACCATTATGATCCTACTATTTGCGCAGCATCTGTTGCTCAAACGAGGCTTTAAACCGCTAGAGCA
AATGCCAGATGCCATCAGGCAACTGCGGCTCCAGGGGCAAGAAATCGATACCCAGCACACGCCAACAGAAATTAGCCCTT
TGATTGAGGAAATCGAACGCCTCATTAATCAACTCGGGCAGAGGGTACAACGTTCACGCAATGCCTTGGGTAATCTTGCC
CACGAAATGAAACGTCCTCTGCAAGGGCTACAATCCTACCTCGAGAGCCTAGCGCCAGAGCAAAGACGCGAAGGCAGTAA
GGTGCTCGCGGATCTGCACCATATTATTGAGCGAGAGCTTAAACGTACTAAAATCGTCGGGCTTTCAACCCCTGGACGTT
TCACCGTGCTCAATGACGATCTGCCGCCACTTATCCAAGTGATGCAGCGCATTTATCCTGAGCGTCAAATTGATAGTCAG
TTTGATAAAACACTTGTCATGCCCTTCGACCGGGACGACTTGCTGGAACTGCTTGGCAATCTGCTCGATAACGCTTGTAA
GCATGCGCATCGACAGATACAGCTTTGTATTAAGCAGACGAATACCATCAATCAAGCGTATCAAATAGAGGTCAGCGACG
ATGGCGAAGGCGTATCGGATAGCGATTTAGCTGTGATTACGGAGCGAGGGATTCGGCTCGATGAGAGCATTCAAGGCCAT
GGTTTAGGCCTGTCGATTTGCAAAGATATTGTCGAGAGTTGTCAGGGGGAACTTAGCTTTACGCATTCAGCTCTTGGCGG
GTTAAAGGTTAGTGTGATATTGCCTCAACCGCATTAA

Upstream 100 bases:

>100_bases
ATGTGATTGAAGTGTACATCAACCGACTCCGCCAACGCCTAGGCAAAGACTATATCGAAACGCGACGCGGCCAAGGTTAT
CGACTCAAGGATGCCTAAGC

Downstream 100 bases:

>100_bases
GCGCACAGCAAAGCAAACACTCTGCTGTGCGATGGGGATTATGATTTGTAAGGCATAGGGCCAAGATAATCTTTCTTACC
CACATCCACACCGTTATGGC

Product: ATPase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MYSLKAYLTRNLLITLTCAMALLLYLLFQGIQILTQDFVASRLQHDADSLISALEPQADGTWSLSADRLPNVYHRVNSGH
YFAINIGEQLLRSRSLFDHAVSLPNLNVGEQQQVTQYVGQEHWLMFSQTIVKNGQTITLWVTEDISSLEQTQLRFLGFAA
VVVLLTIMILLFAQHLLLKRGFKPLEQMPDAIRQLRLQGQEIDTQHTPTEISPLIEEIERLINQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLAPEQRREGSKVLADLHHIIERELKRTKIVGLSTPGRFTVLNDDLPPLIQVMQRIYPERQIDSQ
FDKTLVMPFDRDDLLELLGNLLDNACKHAHRQIQLCIKQTNTINQAYQIEVSDDGEGVSDSDLAVITERGIRLDESIQGH
GLGLSICKDIVESCQGELSFTHSALGGLKVSVILPQPH

Sequences:

>Translated_438_residues
MYSLKAYLTRNLLITLTCAMALLLYLLFQGIQILTQDFVASRLQHDADSLISALEPQADGTWSLSADRLPNVYHRVNSGH
YFAINIGEQLLRSRSLFDHAVSLPNLNVGEQQQVTQYVGQEHWLMFSQTIVKNGQTITLWVTEDISSLEQTQLRFLGFAA
VVVLLTIMILLFAQHLLLKRGFKPLEQMPDAIRQLRLQGQEIDTQHTPTEISPLIEEIERLINQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLAPEQRREGSKVLADLHHIIERELKRTKIVGLSTPGRFTVLNDDLPPLIQVMQRIYPERQIDSQ
FDKTLVMPFDRDDLLELLGNLLDNACKHAHRQIQLCIKQTNTINQAYQIEVSDDGEGVSDSDLAVITERGIRLDESIQGH
GLGLSICKDIVESCQGELSFTHSALGGLKVSVILPQPH
>Mature_438_residues
MYSLKAYLTRNLLITLTCAMALLLYLLFQGIQILTQDFVASRLQHDADSLISALEPQADGTWSLSADRLPNVYHRVNSGH
YFAINIGEQLLRSRSLFDHAVSLPNLNVGEQQQVTQYVGQEHWLMFSQTIVKNGQTITLWVTEDISSLEQTQLRFLGFAA
VVVLLTIMILLFAQHLLLKRGFKPLEQMPDAIRQLRLQGQEIDTQHTPTEISPLIEEIERLINQLGQRVQRSRNALGNLA
HEMKRPLQGLQSYLESLAPEQRREGSKVLADLHHIIERELKRTKIVGLSTPGRFTVLNDDLPPLIQVMQRIYPERQIDSQ
FDKTLVMPFDRDDLLELLGNLLDNACKHAHRQIQLCIKQTNTINQAYQIEVSDDGEGVSDSDLAVITERGIRLDESIQGH
GLGLSICKDIVESCQGELSFTHSALGGLKVSVILPQPH

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=299, Percent_Identity=28.4280936454849, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.1062271062271, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=26.3598326359833, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=288, Percent_Identity=23.9583333333333, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=25.1748251748252, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49468; Mature: 49468

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLKAYLTRNLLITLTCAMALLLYLLFQGIQILTQDFVASRLQHDADSLISALEPQADG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TWSLSADRLPNVYHRVNSGHYFAINIGEQLLRSRSLFDHAVSLPNLNVGEQQQVTQYVGQ
CCCCCHHHCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
EHWLMFSQTIVKNGQTITLWVTEDISSLEQTQLRFLGFAAVVVLLTIMILLFAQHLLLKR
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFKPLEQMPDAIRQLRLQGQEIDTQHTPTEISPLIEEIERLINQLGQRVQRSRNALGNLA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEMKRPLQGLQSYLESLAPEQRREGSKVLADLHHIIERELKRTKIVGLSTPGRFTVLNDD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCC
LPPLIQVMQRIYPERQIDSQFDKTLVMPFDRDDLLELLGNLLDNACKHAHRQIQLCIKQT
CCHHHHHHHHHCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTINQAYQIEVSDDGEGVSDSDLAVITERGIRLDESIQGHGLGLSICKDIVESCQGELSF
CCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
THSALGGLKVSVILPQPH
HHHHHCCEEEEEECCCCC
>Mature Secondary Structure
MYSLKAYLTRNLLITLTCAMALLLYLLFQGIQILTQDFVASRLQHDADSLISALEPQADG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TWSLSADRLPNVYHRVNSGHYFAINIGEQLLRSRSLFDHAVSLPNLNVGEQQQVTQYVGQ
CCCCCHHHCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCC
EHWLMFSQTIVKNGQTITLWVTEDISSLEQTQLRFLGFAAVVVLLTIMILLFAQHLLLKR
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFKPLEQMPDAIRQLRLQGQEIDTQHTPTEISPLIEEIERLINQLGQRVQRSRNALGNLA
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEMKRPLQGLQSYLESLAPEQRREGSKVLADLHHIIERELKRTKIVGLSTPGRFTVLNDD
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCC
LPPLIQVMQRIYPERQIDSQFDKTLVMPFDRDDLLELLGNLLDNACKHAHRQIQLCIKQT
CCHHHHHHHHHCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTINQAYQIEVSDDGEGVSDSDLAVITERGIRLDESIQGHGLGLSICKDIVESCQGELSF
CCCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHH
THSALGGLKVSVILPQPH
HHHHHCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]