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The map label for this gene is pepQ [H]

Identifier: 117918484

GI number: 117918484

Start: 32031

End: 33350

Strand: Direct

Name: pepQ [H]

Synonym: Shewana3_0025

Alternate gene names: 117918484

Gene position: 32031-33350 (Clockwise)

Preceding gene: 117918477

Following gene: 117918485

Centisome position: 0.64

GC content: 48.11

Gene sequence:

>1320_bases
ATGGATCACTTGGCTCATCACTATCATGCCCACATCGCCGAGCTTAATCGTCGAGTCGCTGAAATTGTATCGCGAGAAGC
ATTATCAGGTTTAGTGATCCACTCGGGTCAGCCACATCGAATGTTTTTGGACGACATTAATTATCCTTTTAAAGCCAATC
CCCACTTCAAGGCTTGGTTACCTGTGTTGGATAACCCTAACTGCTGGTTAGTGGTGAATGGTCGCGATAAGCCACAACTG
ATTTTTTATCGCCCAGTGGATTTTTGGCATAAGGTGTCGGACGTGCCGGAGATGTTCTGGACCGAGCATTTTGAGATCAA
GTTACTCACTAAGGCCGATAAGGTTGCCGAGCTATTGCCTAGCGATATCACCAACTGGGCTTATTTGGGTGAGCATTTAG
ATGTGGCTGAGGTACTGGGTTTCACCAGTCGCAATCCTGACTCTGTGATGAGCTATCTGCATTTCCATCGCACTACTAAA
ACCGAATATGAACTCGAATGTATGCGCCGTGCGAACCAGATCGCGGTGCAAGGGCATTTAGCGGCTAAAAATGCCTTCTA
TAACGGTGCGAGCGAGTTTGAAATTCAGCAGCAGTATTTATCTGCTGTGGGACAGGGCGAGAACGAAGTGCCCTACGGTA
ATATCATTGCCTTAAATCAAAATGCGGCGATTTTGCATTACACCGCGCTCGAGCATCAAAATCCGGCGCGGCGTTTATCT
TTTTTAATCGATGCGGGAGCCAGTTATTTTGGCTATGCGTCGGATATTACTCGTACCTATGCGTTTGAGAAGAATCGCTT
TGATGAATTAATCACTGCTATGAACAAGGCGCAGCTCGAACTGATCGATATGATGCGCCCAGGTGTGCGTTATCCCGATT
TACACTTGGCGACCCATGGCAAAGTCGCGCAAATGCTGTTGGATTTTGAGTTAGCCACGGGCGATGCCCAAGGCTTAGTC
GATCAAGGCATAACCAGCGCCTTCTTCCCCCACGGACTCGGCCATATGTTAGGTTTGCAAGTACATGATGTGGGAGGTTT
TTCCTTCGATGAGCGTGGTACCCATATTCCTGCACCAGAAGCCCATCCGTTCCTGCGTTGCACCCGCATTTTAGCGCCAA
ACCAAGTGCTTACGATGGAGCCAGGTTTGTACATTATCGACACTTTACTCAATGAGCTAAAACAAGATAGCCGTGGTCAG
CAGATCAATTGGCGCACCGTTGATGAGCTGCGACCTTTCGGTGGTATTCGTATCGAGGATAATGTGATTGTGCATCAAGA
TCGAAACGAAAATATGACCCGCGAACTGGGCTTAGCGTGA

Upstream 100 bases:

>100_bases
TGAAATCACAGGGCGTTAGCGAAGGAAAACACTGAGCCTATATGGCTTAGTCAGATTTTCGGTTTTTTTATTAACTATCG
TTCATTACAGGATATGACAC

Downstream 100 bases:

>100_bases
TTTTAGGGAGAGCGAGTGCTCGAAAGTTATCTGATACCGAGTGAAAGTGTGCAGATAGAAGAAGAGATAAAGCATAGCCG
CTTTATCTCTTTTCTATTTC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA

Sequences:

>Translated_439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA
>Mature_439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYRPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFSFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=444, Percent_Identity=28.8288288288288, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI260593665, Length=288, Percent_Identity=34.0277777777778, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI260593663, Length=440, Percent_Identity=27.0454545454545, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI11559925, Length=283, Percent_Identity=25.0883392226148, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=49.6613995485327, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789275, Length=290, Percent_Identity=31.7241379310345, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788728, Length=278, Percent_Identity=28.0575539568345, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=451, Percent_Identity=29.490022172949, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321118, Length=290, Percent_Identity=32.7586206896552, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21357079, Length=456, Percent_Identity=26.5350877192982, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19920384, Length=291, Percent_Identity=29.2096219931272, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 49984; Mature: 49984

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHCCCCEEEEEEECHHHHHHHHH
SDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTKTEYELECMRRANQIAVQGHL
HHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHG
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
KVAQMLLDFELATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFSFDERGTHIPAPE
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCHHHHHCEEEEECCCCCCCCCCCCCCCCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQQINWRTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLA
CEEEECCCCCCHHHHHCCC
>Mature Secondary Structure
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYRPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHCCCCEEEEEEECHHHHHHHHH
SDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTKTEYELECMRRANQIAVQGHL
HHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHG
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
KVAQMLLDFELATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFSFDERGTHIPAPE
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCHHHHHCEEEEECCCCCCCCCCCCCCCCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRGQQINWRTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLA
CEEEECCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA