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The map label for this gene is pabA [H]

Identifier: 116874113

GI number: 116874113

Start: 2725136

End: 2725708

Strand: Direct

Name: pabA [H]

Synonym: lwe2697

Alternate gene names: 116874113

Gene position: 2725136-2725708 (Clockwise)

Preceding gene: 116874109

Following gene: 116874114

Centisome position: 96.84

GC content: 37.52

Gene sequence:

>573_bases
GTGATTTTATTAATTGATCATAATGATTCGTTTACATATAATTTATATCAATATTTTTTAGAACTTCAAGAAGATGTACA
TGTAGTCTCTGCTACAGATTTAACCCTTGAAAAACTACACCAACTTGCTCCTGAAATGGTTGTTCTTTCGCCTGGTCCTG
GCTCCCCAGAAGATTTTCCTTTGAGTTTAGCGATTTTGAGTGAAATTAATGTTCCTATACTCGGGATTTGCCTTGGCCAT
CAAATGATTGGGCATTTTTTTGGTGCAAAAGTAGTTAGAGCGGACATCCCTGTTCACGGAAAAACTAGTATAATCTCGCA
TGATGGTTCAGGTTTGTTTGCTGGTCTTAATCCTAAATTCCAAGTAACCCGCTATCATTCTTTAGTGATAGCTCCTGATT
CCGTTCCGGCCGATTTAAGAGTAACTGCTATGACTGAAAATGGTGTTTTGATGGCACTAGAGCATTTGAATAAAGCAATA
TACAGTGTCCAATTTCATCCAGAAGCAATTCTTTCTGAAAACGGTCACGCTATTTTAGAAAATTTTGTACGACTGGGGAG
GAATGCCAAATGA

Upstream 100 bases:

>100_bases
TCCATTCCACTTGTTTTATGGCTTCAAACATTTTGCACTTGTTATCTCACTATCTATTTGCTATAAAGGAGTATAACCGT
TTTAGTTAGGGGGACTTTAA

Downstream 100 bases:

>100_bases
GTTATTTGCGATTTGATTTTGAAGGCGAAGTAAAGATTTTTGAAAACCCATTGCAAGAATTTGTGGCACACCATTTATCA
GAAGTTCTCCCAGCGATGAA

Product: glutamine amidotransferase, class I

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MILLIDHNDSFTYNLYQYFLELQEDVHVVSATDLTLEKLHQLAPEMVVLSPGPGSPEDFPLSLAILSEINVPILGICLGH
QMIGHFFGAKVVRADIPVHGKTSIISHDGSGLFAGLNPKFQVTRYHSLVIAPDSVPADLRVTAMTENGVLMALEHLNKAI
YSVQFHPEAILSENGHAILENFVRLGRNAK

Sequences:

>Translated_190_residues
MILLIDHNDSFTYNLYQYFLELQEDVHVVSATDLTLEKLHQLAPEMVVLSPGPGSPEDFPLSLAILSEINVPILGICLGH
QMIGHFFGAKVVRADIPVHGKTSIISHDGSGLFAGLNPKFQVTRYHSLVIAPDSVPADLRVTAMTENGVLMALEHLNKAI
YSVQFHPEAILSENGHAILENFVRLGRNAK
>Mature_190_residues
MILLIDHNDSFTYNLYQYFLELQEDVHVVSATDLTLEKLHQLAPEMVVLSPGPGSPEDFPLSLAILSEINVPILGICLGH
QMIGHFFGAKVVRADIPVHGKTSIISHDGSGLFAGLNPKFQVTRYHSLVIAPDSVPADLRVTAMTENGVLMALEHLNKAI
YSVQFHPEAILSENGHAILENFVRLGRNAK

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=139, Percent_Identity=33.8129496402878, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=51.8918918918919, Blast_Score=191, Evalue=2e-50,
Organism=Escherichia coli, GI1787517, Length=187, Percent_Identity=40.1069518716578, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1788854, Length=193, Percent_Identity=26.9430051813472, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786215, Length=141, Percent_Identity=30.4964539007092, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193204318, Length=125, Percent_Identity=35.2, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133901714, Length=140, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=140, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=140, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322638, Length=187, Percent_Identity=40.6417112299465, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324361, Length=211, Percent_Identity=35.0710900473934, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323873, Length=186, Percent_Identity=30.1075268817204, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281365319, Length=139, Percent_Identity=32.3741007194245, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 20872; Mature: 20872

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLIDHNDSFTYNLYQYFLELQEDVHVVSATDLTLEKLHQLAPEMVVLSPGPGSPEDFP
CEEEEECCCCEEHHHHHHHHHHHHCEEEEEECCHHHHHHHHCCCCEEEECCCCCCCCCCC
LSLAILSEINVPILGICLGHQMIGHFFGAKVVRADIPVHGKTSIISHDGSGLFAGLNPKF
EEEEEEHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECCCCCE
QVTRYHSLVIAPDSVPADLRVTAMTENGVLMALEHLNKAIYSVQFHPEAILSENGHAILE
EEEEEEEEEECCCCCCCCEEEEEEECCCEEEEHHHHHHHHEEEEECCHHEECCCCHHHHH
NFVRLGRNAK
HHHHHCCCCC
>Mature Secondary Structure
MILLIDHNDSFTYNLYQYFLELQEDVHVVSATDLTLEKLHQLAPEMVVLSPGPGSPEDFP
CEEEEECCCCEEHHHHHHHHHHHHCEEEEEECCHHHHHHHHCCCCEEEECCCCCCCCCCC
LSLAILSEINVPILGICLGHQMIGHFFGAKVVRADIPVHGKTSIISHDGSGLFAGLNPKF
EEEEEEHHCCCCEEEHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEECCCEEEECCCCCE
QVTRYHSLVIAPDSVPADLRVTAMTENGVLMALEHLNKAIYSVQFHPEAILSENGHAILE
EEEEEEEEEECCCCCCCCEEEEEEECCCEEEEHHHHHHHHEEEEECCHHEECCCCHHHHH
NFVRLGRNAK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350604; 2403545; 9278503; 2546924; 8096767 [H]