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The map label for this gene is pabB [H]

Identifier: 116874114

GI number: 116874114

Start: 2725705

End: 2727411

Strand: Direct

Name: pabB [H]

Synonym: lwe2698

Alternate gene names: 116874114

Gene position: 2725705-2727411 (Clockwise)

Preceding gene: 116874113

Following gene: 116874115

Centisome position: 96.86

GC content: 37.2

Gene sequence:

>1707_bases
ATGAGTTATTTGCGATTTGATTTTGAAGGCGAAGTAAAGATTTTTGAAAACCCATTGCAAGAATTTGTGGCACACCATTT
ATCAGAAGTTCTCCCAGCGATGAAAGCAGCGGAAGAAGCCCAAGATGCTGGTAAGTATGTTGCTGGTTTTGTAAGTTATG
AAGCGGCTCCTGCTTTTCGGAGTAATTTGCAAACAAAAAAACCGTCAATGAACATGCCACTTGTCTGGTTTGGTGTATAT
GATCATTTTTCTGATGTTACTACTAAAAGCACAGATTCTGCACCACTTTCTTTTCAAATGGATACAAATTATTTCGATTA
CACGGAAAAAATAACTACCATCAAATCTGAAATTGCTGCTGGTAACACCTATCAAATGAACTACACCGTCCGCCTAAACA
GTGATGTTCCTAGTAACTTTTCTGCCAAAGCAACTTATGAAACTTTACAAAAAGCTGGAAAAGCGAATTACACTGCGCTC
CTATCGACTAATGAATTTGACATTATCTCCACTTCTCCAGAATTATTTTTTAAATGGAAGAAAAACACTTTAACTACTCG
TCCAATGAAAGGCACTGTTCGACGTGGAACCACACAAAAAGCTGATTTAGAAGCACATGATTGGCTAAAAAATGATCCGA
AAAATCGCGCAGAAAATGTAATGATTGTTGATTTACTGCGAAATGACCTCGGAATGATTGCAGTACCTGGGAGTGTGAAA
GTTCCTAAATTAATGACTTTAGAGCCATATCCAACTGTTTGGCAAATGACTTCTACTGTAACAGCAGAGACGCTTCCAAA
TACAAGCTTAACATCAATATTTCAAGCGCTTTTCCCTTGTGGTTCAATAACTGGCGCCCCTAAAGCTCGAACAATGGAAA
TTATTTCGCAGTTAGAAGATTCTCCGCGCGACGTTTATTGTGGTGCAATTGGTTTTTTAGAACCTAACGGAGATGCCATT
TTCAACGTTCCGATTCGTACTATTTCTATTGCAAATAAGAAAGCTACTTATGGCGTGGGTGGCGGCATTGTTTGGGATTC
TGATGCGGAAAGTGAATTTTCCGAAGTCCATGCAAAAACAGCTCTCTTAGAAAAAATGCACCCATTTTCTTTAATTGAAT
GTTTGCGCCTTGAAAACGGGAGGCTTTTTCGAATAGATTTTCATTTAAAACGTCTTCAAACAAGTGCTGCGTTCTTTGGT
TTCCCTTTTAATAGAAAAGAGATAGAGGCATTATGGCTGAAAAACGCGCAAAACAATACTACTGGTGTTTTTAAAATGCG
CTTTTTACTCGATTTAGATGGAACGACACATTTAGAATTGACAAAAATAAGCGAACATAATAAAACGTTGACCGCTCAGC
TTGCTAAAAATCCAATCTCGACGGACAATTCCTTTCTCTATCATAAAACTACTTCACGCTTTATGTATGAGAAACTAAAA
AGTACTAAAACAGACGAGACTTTGCTTTGGAACGAACGCGGAGAATTAACAGAATTTATAAATGGTAATATAGTTCTAGC
CAAAAATGGTTGTTTTTTCACGCCACCAGTAACTTCTGGTCTTCTTCCTGGCACAATGAGGGAGGAACTTTTAACTAAAA
ATAGAATTTCTGAAAAAGTATTAACAAAAAAAGACCTTTTTGATGCAGAGTCTGTATGGTTAATTAATAGTGTAAGAGGA
TTTGTAGAGGTCAAAATTCAACCTTAA

Upstream 100 bases:

>100_bases
ATAAAGCAATATACAGTGTCCAATTTCATCCAGAAGCAATTCTTTCTGAAAACGGTCACGCTATTTTAGAAAATTTTGTA
CGACTGGGGAGGAATGCCAA

Downstream 100 bases:

>100_bases
AATTCATTATTTTTCACAATTTAAAATGATTTTTACACTTAAATTCGCCATAATTTCGCCATATTTATGATTTTCGAAAA
AAATACTTGCAAATTTTCAC

Product: para-aminobenzoate synthase component I / 4- amino-4-deoxychorismate lyase, putative

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSYLRFDFEGEVKIFENPLQEFVAHHLSEVLPAMKAAEEAQDAGKYVAGFVSYEAAPAFRSNLQTKKPSMNMPLVWFGVY
DHFSDVTTKSTDSAPLSFQMDTNYFDYTEKITTIKSEIAAGNTYQMNYTVRLNSDVPSNFSAKATYETLQKAGKANYTAL
LSTNEFDIISTSPELFFKWKKNTLTTRPMKGTVRRGTTQKADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
VPKLMTLEPYPTVWQMTSTVTAETLPNTSLTSIFQALFPCGSITGAPKARTMEIISQLEDSPRDVYCGAIGFLEPNGDAI
FNVPIRTISIANKKATYGVGGGIVWDSDAESEFSEVHAKTALLEKMHPFSLIECLRLENGRLFRIDFHLKRLQTSAAFFG
FPFNRKEIEALWLKNAQNNTTGVFKMRFLLDLDGTTHLELTKISEHNKTLTAQLAKNPISTDNSFLYHKTTSRFMYEKLK
STKTDETLLWNERGELTEFINGNIVLAKNGCFFTPPVTSGLLPGTMREELLTKNRISEKVLTKKDLFDAESVWLINSVRG
FVEVKIQP

Sequences:

>Translated_568_residues
MSYLRFDFEGEVKIFENPLQEFVAHHLSEVLPAMKAAEEAQDAGKYVAGFVSYEAAPAFRSNLQTKKPSMNMPLVWFGVY
DHFSDVTTKSTDSAPLSFQMDTNYFDYTEKITTIKSEIAAGNTYQMNYTVRLNSDVPSNFSAKATYETLQKAGKANYTAL
LSTNEFDIISTSPELFFKWKKNTLTTRPMKGTVRRGTTQKADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
VPKLMTLEPYPTVWQMTSTVTAETLPNTSLTSIFQALFPCGSITGAPKARTMEIISQLEDSPRDVYCGAIGFLEPNGDAI
FNVPIRTISIANKKATYGVGGGIVWDSDAESEFSEVHAKTALLEKMHPFSLIECLRLENGRLFRIDFHLKRLQTSAAFFG
FPFNRKEIEALWLKNAQNNTTGVFKMRFLLDLDGTTHLELTKISEHNKTLTAQLAKNPISTDNSFLYHKTTSRFMYEKLK
STKTDETLLWNERGELTEFINGNIVLAKNGCFFTPPVTSGLLPGTMREELLTKNRISEKVLTKKDLFDAESVWLINSVRG
FVEVKIQP
>Mature_567_residues
SYLRFDFEGEVKIFENPLQEFVAHHLSEVLPAMKAAEEAQDAGKYVAGFVSYEAAPAFRSNLQTKKPSMNMPLVWFGVYD
HFSDVTTKSTDSAPLSFQMDTNYFDYTEKITTIKSEIAAGNTYQMNYTVRLNSDVPSNFSAKATYETLQKAGKANYTALL
STNEFDIISTSPELFFKWKKNTLTTRPMKGTVRRGTTQKADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVKV
PKLMTLEPYPTVWQMTSTVTAETLPNTSLTSIFQALFPCGSITGAPKARTMEIISQLEDSPRDVYCGAIGFLEPNGDAIF
NVPIRTISIANKKATYGVGGGIVWDSDAESEFSEVHAKTALLEKMHPFSLIECLRLENGRLFRIDFHLKRLQTSAAFFGF
PFNRKEIEALWLKNAQNNTTGVFKMRFLLDLDGTTHLELTKISEHNKTLTAQLAKNPISTDNSFLYHKTTSRFMYEKLKS
TKTDETLLWNERGELTEFINGNIVLAKNGCFFTPPVTSGLLPGTMREELLTKNRISEKVLTKKDLFDAESVWLINSVRGF
VEVKIQP

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=254, Percent_Identity=39.3700787401575, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787518, Length=258, Percent_Identity=30.6201550387597, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI87082077, Length=210, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786809, Length=196, Percent_Identity=24.4897959183673, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=292, Percent_Identity=33.2191780821918, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324361, Length=286, Percent_Identity=29.3706293706294, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 63951; Mature: 63819

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLRFDFEGEVKIFENPLQEFVAHHLSEVLPAMKAAEEAQDAGKYVAGFVSYEAAPAFR
CCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SNLQTKKPSMNMPLVWFGVYDHFSDVTTKSTDSAPLSFQMDTNYFDYTEKITTIKSEIAA
HCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
GNTYQMNYTVRLNSDVPSNFSAKATYETLQKAGKANYTALLSTNEFDIISTSPELFFKWK
CCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHEEEEC
KNTLTTRPMKGTVRRGTTQKADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
CCCCCCCCCCCCHHCCCCCCCCCCHHHHHCCCCCHHHCCEEEEEEHHCCCCEEEECCCCC
VPKLMTLEPYPTVWQMTSTVTAETLPNTSLTSIFQALFPCGSITGAPKARTMEIISQLED
CCEEEEECCCCCCEEEEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
SPRDVYCGAIGFLEPNGDAIFNVPIRTISIANKKATYGVGGGIVWDSDAESEFSEVHAKT
CCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCCEECCCCCEEECCCCHHHHHHHHHHH
ALLEKMHPFSLIECLRLENGRLFRIDFHLKRLQTSAAFFGFPFNRKEIEALWLKNAQNNT
HHHHHCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHEEECCCCHHHHHEEEECCCCCCC
TGVFKMRFLLDLDGTTHLELTKISEHNKTLTAQLAKNPISTDNSFLYHKTTSRFMYEKLK
CEEEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHCCCCCCCCCEEEECHHHHHHHHHHH
STKTDETLLWNERGELTEFINGNIVLAKNGCFFTPPVTSGLLPGTMREELLTKNRISEKV
CCCCCCEEEECCCCCHHHHHCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LTKKDLFDAESVWLINSVRGFVEVKIQP
HHHHHCCCCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure 
SYLRFDFEGEVKIFENPLQEFVAHHLSEVLPAMKAAEEAQDAGKYVAGFVSYEAAPAFR
CEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SNLQTKKPSMNMPLVWFGVYDHFSDVTTKSTDSAPLSFQMDTNYFDYTEKITTIKSEIAA
HCCCCCCCCCCCCEEEEEHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
GNTYQMNYTVRLNSDVPSNFSAKATYETLQKAGKANYTALLSTNEFDIISTSPELFFKWK
CCEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHEEEEC
KNTLTTRPMKGTVRRGTTQKADLEAHDWLKNDPKNRAENVMIVDLLRNDLGMIAVPGSVK
CCCCCCCCCCCCHHCCCCCCCCCCHHHHHCCCCCHHHCCEEEEEEHHCCCCEEEECCCCC
VPKLMTLEPYPTVWQMTSTVTAETLPNTSLTSIFQALFPCGSITGAPKARTMEIISQLED
CCEEEEECCCCCCEEEEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
SPRDVYCGAIGFLEPNGDAIFNVPIRTISIANKKATYGVGGGIVWDSDAESEFSEVHAKT
CCCEEEEEEEEEECCCCCEEEECCEEEEEECCCCCEECCCCCEEECCCCHHHHHHHHHHH
ALLEKMHPFSLIECLRLENGRLFRIDFHLKRLQTSAAFFGFPFNRKEIEALWLKNAQNNT
HHHHHCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHEEECCCCHHHHHEEEECCCCCCC
TGVFKMRFLLDLDGTTHLELTKISEHNKTLTAQLAKNPISTDNSFLYHKTTSRFMYEKLK
CEEEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHCCCCCCCCCEEEECHHHHHHHHHHH
STKTDETLLWNERGELTEFINGNIVLAKNGCFFTPPVTSGLLPGTMREELLTKNRISEKV
CCCCCCEEEECCCCCHHHHHCCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
LTKKDLFDAESVWLINSVRGFVEVKIQP
HHHHHCCCCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3057324; 11677609; 2251281 [H]