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The map label for this gene is yuxJ [H]

Identifier: 116873742

GI number: 116873742

Start: 2371587

End: 2372798

Strand: Direct

Name: yuxJ [H]

Synonym: lwe2326

Alternate gene names: 116873742

Gene position: 2371587-2372798 (Clockwise)

Preceding gene: 116873739

Following gene: 116873743

Centisome position: 84.27

GC content: 38.78

Gene sequence:

>1212_bases
ATGACAACTCGAACAAGGAATTTATACATCTTAATGTTGGCAAATTTGCTGATGTCAGCCAGTATGACAATGATTATGCC
ATTTTTATCTCTCTACATTGAAACATTTGGTGATTATAGCAATGCGTACGTGCAAAGGTGGGCCGGATACATTTTTGGCG
TGACATTTTTAATTGCATTTATATTTTCACCGATTTGGGGACGTATTGGCGATAAGCACGGTTATAAAGGTATTTTGATT
TTGACTTCGGTCGGTTTATCCATTTGTATTTTTTTGATGGGATTTGCGCATTCAGTCACTTACTTACTTATTTTGCGGAT
TTTCATGGGTGTAGTAACAGGTTTTATTGGTGTGAGTAATGCCTTTATTGCGCGTCAAACACCTCGTAATGAAGCTGGGA
AAATTCTTGGTACATTGCAACTAGGTGGGGTTACCGGTATGCTATTTGGTCCACTTATTGGTGGCGCGATGGCGGATTTA
TTTGGATTTAAAGATACTTTTACGATAACGGGGATTGCAATGATGGTTGCGGCTTTGCTTGTTGCTTTTGGTGTAAAAGA
AATCCGAACAGAAGAGCAAAAAGAAGCTGCCAAAGTAGTATATTCTCGCCGTGCGGTTTTAAAACAAATTTTTACGCTTC
GTGTTCTTTTTACCGTGATGGTCATTACAGCGCTTATCCAAATTGCAAACTTTAGTGTTCAACCGCTTCTTGCACTTTAT
GTAGGCGATATGACAAATTCAAATAACATTGCGTTCTTATCAGGTTTGGCCTTTTCTGCGACTGGCTTTGGGAATTTAGT
GATGACACGGAAATGGGGACAACTTGGTGATAAATACGGGTATGAAAAGATTTTAAATATCCTATTAATTATGGCAGCAG
TTTTTGTAATACCGCAAGCTTTCGCCACAAATCTATGGGTATTTGTTTTCTTCCGCTTTTTATTTGGTATTGCGATTGGC
GGAATGGTGCCTTGTACAACAGCATATATTCGACTGGCAGCTCCAGGTGTCATGCAAGGTGAAATGCTAGGTTATAATCA
AAGCGCTCGTTTTCTAGGGAATGTTATTGGACCTATTCTTGGTGGTACTCTCGCTGGTTATACAGGCATTCCAAGCGTTT
TCCTATTTATGAGTTTTATGTTTCTACTTGCATTTTTCATTTTACTTTACGCACTTCATTCTGACCGAAAACGGCATGTT
AATGTTGATTAA

Upstream 100 bases:

>100_bases
CCAAAAATGCACATCCTTCACTTTATTTTTCATTCGCTCCCTTTTATTCTATAATGAAAAGGACAGTTTTAACAATAATA
CGAATAGAGATGATTCTTTT

Downstream 100 bases:

>100_bases
TCAAAGTAAACCTAAGTTTTTTTCTTAGGTTTATTTTTTTCTTCTTCCTATTTAACTATTTTTTAAAATTGTAGAAATTG
ATTTATAAAGTTAAGTTTCC

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: ORF1 [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILI
LTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADL
FGFKDTFTITGIAMMVAALLVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
VGDMTNSNNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFVFFRFLFGIAIG
GMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGYTGIPSVFLFMSFMFLLAFFILLYALHSDRKRHV
NVD

Sequences:

>Translated_403_residues
MTTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILI
LTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADL
FGFKDTFTITGIAMMVAALLVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
VGDMTNSNNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFVFFRFLFGIAIG
GMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGYTGIPSVFLFMSFMFLLAFFILLYALHSDRKRHV
NVD
>Mature_402_residues
TTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILIL
TSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADLF
GFKDTFTITGIAMMVAALLVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALYV
GDMTNSNNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFVFFRFLFGIAIGG
MVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGYTGIPSVFLFMSFMFLLAFFILLYALHSDRKRHVN
VD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=34.8484848484849, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87082404, Length=347, Percent_Identity=26.2247838616715, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319871, Length=151, Percent_Identity=27.8145695364238, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44330; Mature: 44199

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IFSPIWGRIGDKHGYKGILILTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADLFGFKDTFTITGIAMMVAALL
HHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGDMTNSNNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQA
HHCCCCCCCEEEEECCHHHCCCCCCHHEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FATNLWVFVFFRFLFGIAIGGMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPIL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GGTLAGYTGIPSVFLFMSFMFLLAFFILLYALHSDRKRHVNVD
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10568751; 7961491 [H]