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The map label for this gene is patB [H]

Identifier: 116873735

GI number: 116873735

Start: 2365668

End: 2366834

Strand: Direct

Name: patB [H]

Synonym: lwe2319

Alternate gene names: 116873735

Gene position: 2365668-2366834 (Clockwise)

Preceding gene: 116873730

Following gene: 116873736

Centisome position: 84.06

GC content: 38.05

Gene sequence:

>1167_bases
TTGAGTCAATTTGATGAAGTCATTCCGCGGATTGGAACTAATTCTGAAAAGTGGGATGGAGCAGAAAAATTATTTGGCAG
AAAAGATATTATTCCAATGTGGGTAGCGGATATGGATTTTCGGGCACCAAAACCTGTACTTGATGCTTTCAAACGTCAAA
TCGATCATGGGATTTTTGGTTACTCAACGAAATCAGAAGCACTCATTCAAGCTGTGATTGATTGGAATAAAGAGCAGCAC
CAGTTTGAAATCGACCCAAGTACGCTATTTTTCAACGGGGCCGTGGTTCCTACAATTTCGCTCGCAATTCGTTCGTTAAC
AAAAGAAGGTGATGCTGTTTTAATGGTTTCGCCAATTTATCCGCCATTTTTTAATGTAACAAAGGCTACGGAACGGCATG
TTGTTATGTCACCATTAATATATGAAAATCACCAATACCGGATGGATTTTGATGATTTAGAAAAACGTATCAAGGAAGAA
AATGTCAAATTATTCCTTCTATGTAATCCGCAAAACCCTGGTGGTCGTTGTTTCACGAAAGAAGAACTCGTAGAATTAGC
GGAACTGTGTGAGAAATACCAAATCCCGATTGTTTCCGATGAAATTCATGCTGATTTAGTAATGAAAAATCATCAACATG
TGCCAATGATGGTTGCAGCGCCATTTTATAAGGATCAAATTATTACTTTAATGGCTGCTACAAAAACATTTAACTTGGCT
GCAATTAAGGCTTCTTACTATATTATTACGAATAAAGATTACCAAGCAAAATTCGCTGCTGAACAAAATTATGCTACCAC
AAACGGGCTTAATGTCTTTGGGATTGTTGGAACAGAAGCGGCCTATCGCTACGGCGCGCCTTGGTTAAAAGAGTTGAAAG
AATATATTTATAGCAATTATGAGTATGTAAAAGCTGAAATCGAAAAAGAAGTTCCAGAAGTTGGCGTTACTGACTTAGAA
GCGACTTACTTAATGTGGCTCGATTGCCGCTCGCTTTCAAAAGACGAAAAAACAATTTACGCAGATTTAATTGAAGCTGG
TGTTGGCGTCCAAATGGGTTCCGGATTTGGTCATTCTGGTAAAGGTTTTGTCCGTTTTAACATCGCTTGTCCAAAAGAAA
CGTTGGAAAAAGCTGTGAAACTTCTGATTCAAGGCTTAAAAAAATAA

Upstream 100 bases:

>100_bases
GTGAAACTTTAACAATTATTCTAAATCCTTCTATAGCGAGCTTTTAAGGGACAATTTGTGCTATAATTAAGGCGAATTAA
AGAGAAGGAGCGTGACATAT

Downstream 100 bases:

>100_bases
TTTACTGAAGAGAAACTAAGTAGCAAATACTTGGTTTCTTTTTTTAGGAAATTGCATATAGCTTTGGTATACTATTCTTT
GGAAAGTGAAATAATGTTCA

Product: aminotransferase, class I

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSQFDEVIPRIGTNSEKWDGAEKLFGRKDIIPMWVADMDFRAPKPVLDAFKRQIDHGIFGYSTKSEALIQAVIDWNKEQH
QFEIDPSTLFFNGAVVPTISLAIRSLTKEGDAVLMVSPIYPPFFNVTKATERHVVMSPLIYENHQYRMDFDDLEKRIKEE
NVKLFLLCNPQNPGGRCFTKEELVELAELCEKYQIPIVSDEIHADLVMKNHQHVPMMVAAPFYKDQIITLMAATKTFNLA
AIKASYYIITNKDYQAKFAAEQNYATTNGLNVFGIVGTEAAYRYGAPWLKELKEYIYSNYEYVKAEIEKEVPEVGVTDLE
ATYLMWLDCRSLSKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRFNIACPKETLEKAVKLLIQGLKK

Sequences:

>Translated_388_residues
MSQFDEVIPRIGTNSEKWDGAEKLFGRKDIIPMWVADMDFRAPKPVLDAFKRQIDHGIFGYSTKSEALIQAVIDWNKEQH
QFEIDPSTLFFNGAVVPTISLAIRSLTKEGDAVLMVSPIYPPFFNVTKATERHVVMSPLIYENHQYRMDFDDLEKRIKEE
NVKLFLLCNPQNPGGRCFTKEELVELAELCEKYQIPIVSDEIHADLVMKNHQHVPMMVAAPFYKDQIITLMAATKTFNLA
AIKASYYIITNKDYQAKFAAEQNYATTNGLNVFGIVGTEAAYRYGAPWLKELKEYIYSNYEYVKAEIEKEVPEVGVTDLE
ATYLMWLDCRSLSKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRFNIACPKETLEKAVKLLIQGLKK
>Mature_387_residues
SQFDEVIPRIGTNSEKWDGAEKLFGRKDIIPMWVADMDFRAPKPVLDAFKRQIDHGIFGYSTKSEALIQAVIDWNKEQHQ
FEIDPSTLFFNGAVVPTISLAIRSLTKEGDAVLMVSPIYPPFFNVTKATERHVVMSPLIYENHQYRMDFDDLEKRIKEEN
VKLFLLCNPQNPGGRCFTKEELVELAELCEKYQIPIVSDEIHADLVMKNHQHVPMMVAAPFYKDQIITLMAATKTFNLAA
IKASYYIITNKDYQAKFAAEQNYATTNGLNVFGIVGTEAAYRYGAPWLKELKEYIYSNYEYVKAEIEKEVPEVGVTDLEA
TYLMWLDCRSLSKDEKTIYADLIEAGVGVQMGSGFGHSGKGFVRFNIACPKETLEKAVKLLIQGLKK

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI56713254, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI95147551, Length=255, Percent_Identity=23.1372549019608, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI169881279, Length=255, Percent_Identity=23.1372549019608, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=32.5641025641026, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788722, Length=399, Percent_Identity=23.3082706766917, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788627, Length=170, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=195, Percent_Identity=25.6410256410256, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=195, Percent_Identity=25.6410256410256, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI18859735, Length=240, Percent_Identity=23.75, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573069, Length=143, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646114, Length=143, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573067, Length=143, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573065, Length=143, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44106; Mature: 43975

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFDEVIPRIGTNSEKWDGAEKLFGRKDIIPMWVADMDFRAPKPVLDAFKRQIDHGIFG
CCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YSTKSEALIQAVIDWNKEQHQFEIDPSTLFFNGAVVPTISLAIRSLTKEGDAVLMVSPIY
CCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCC
PPFFNVTKATERHVVMSPLIYENHQYRMDFDDLEKRIKEENVKLFLLCNPQNPGGRCFTK
CCCCCCCCCCCCEEEECCEEECCCCEEECHHHHHHHHHHCCCEEEEEECCCCCCCCCCCH
EELVELAELCEKYQIPIVSDEIHADLVMKNHQHVPMMVAAPFYKDQIITLMAATKTFNLA
HHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCEEEECCCHHHHEEEEEECCCCEEEE
AIKASYYIITNKDYQAKFAAEQNYATTNGLNVFGIVGTEAAYRYGAPWLKELKEYIYSNY
EEEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCH
EYVKAEIEKEVPEVGVTDLEATYLMWLDCRSLSKDEKTIYADLIEAGVGVQMGSGFGHSG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHHHHCCCCEEECCCCCCCC
KGFVRFNIACPKETLEKAVKLLIQGLKK
CCEEEEEEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQFDEVIPRIGTNSEKWDGAEKLFGRKDIIPMWVADMDFRAPKPVLDAFKRQIDHGIFG
CCHHHHHHCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
YSTKSEALIQAVIDWNKEQHQFEIDPSTLFFNGAVVPTISLAIRSLTKEGDAVLMVSPIY
CCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCC
PPFFNVTKATERHVVMSPLIYENHQYRMDFDDLEKRIKEENVKLFLLCNPQNPGGRCFTK
CCCCCCCCCCCCEEEECCEEECCCCEEECHHHHHHHHHHCCCEEEEEECCCCCCCCCCCH
EELVELAELCEKYQIPIVSDEIHADLVMKNHQHVPMMVAAPFYKDQIITLMAATKTFNLA
HHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCCCCEEEECCCHHHHEEEEEECCCCEEEE
AIKASYYIITNKDYQAKFAAEQNYATTNGLNVFGIVGTEAAYRYGAPWLKELKEYIYSNY
EEEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHCCH
EYVKAEIEKEVPEVGVTDLEATYLMWLDCRSLSKDEKTIYADLIEAGVGVQMGSGFGHSG
HHHHHHHHHCCCCCCCCCCCEEEEEEEEHHCCCCCHHHHHHHHHHCCCCEEECCCCCCCC
KGFVRFNIACPKETLEKAVKLLIQGLKK
CCEEEEEEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]