Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 116873652

GI number: 116873652

Start: 2272571

End: 2273446

Strand: Direct

Name: prsA [H]

Synonym: lwe2236

Alternate gene names: 116873652

Gene position: 2272571-2273446 (Clockwise)

Preceding gene: 116873651

Following gene: 116873663

Centisome position: 80.76

GC content: 34.82

Gene sequence:

>876_bases
ATGAAGAAAAAATTAATTCTTGGACTTGTCATGGTAATGGCATTGTTCAGTCTAGCAGCGTGTGGTGGCGGCGGTGATGT
CGTTAAGACTGATGCTGGTGATGTAACGCAAGATGAGCTTTACGAAGCAATGAAAGATAAATACGGTTCAGAGTTCGTAC
AACAACTTACTTTCGAAAAAGTCCTTGGAGATAAATACAAAGTAAGCGATGAAGATGTTGATAAAAAATTCAAAGAGTAC
AAAGCTCAATATGGCGATCAATTCGCTGCTGTTCTAGCTCAAAGTGGCTTAACAGAAAAAACATTCAAAAGCCAACTTAA
GTATAACTTACTAGTTCAAAAAGCTACTGAAGCTAATACTGATACTAGTGATAAAGCACTTAAAGAGTACTACAAAACTT
GGCAACCAGATATCACTGTTAGTCATATTCTAGTAGCTGACGAGAAAAAAGCTAAAGAAGTTGAACAAAAACTTAAAGAC
GGCGCAAAATTCTCTGATTTAGCAAAAGAATATTCAACTGATACAGCAACAAAAGAAAACGGTGGTCAATTAGCAGCATT
TGGTCCTGGTAAAATGGATCCAGCATTTGAAAAAGCAGCTTATGCACTTAAAAACAAAGGTGATATCAGCGCTCCAGTAA
AAACGCAATACGGATACCACATTATTCAAATGGATGAACCAGCTACAAAAACAACTTTTGATAAAGATAAAAAAGCGGTA
AAAGCTTCTTATCTTACTTCCCAATTAACCAACGAAAACATGCAAAAAACACTGAAAAAAGAATTCAAAGATGCTAATGT
AAAAGTTGAAGATAAAGACTTGAAAGATGCTTTCAAAGATTTTGATAGTTCTTCTTCCGAAAAATCATCTAAATAA

Upstream 100 bases:

>100_bases
TAAATTTCTTTCATCTTTTCTTTTTGGCTTTAATTTATGTTATGATAGTTATTGTGTTAAGCGGGAATTATTCCAACAAC
TAAGGAGTGTGTTTTATTCA

Downstream 100 bases:

>100_bases
GTAAGCTAAAAACACGTTTGGAATTTTCCAAACGTGTTTTTTTAATGTAAAAAGCGTTGCTCGATTAATTTATACCGAAC
AACGCTTTTTTATACTCTAT

Product: prsA protein, export protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKKKLILGLVMVMALFSLAACGGGGDVVKTDAGDVTQDELYEAMKDKYGSEFVQQLTFEKVLGDKYKVSDEDVDKKFKEY
KAQYGDQFAAVLAQSGLTEKTFKSQLKYNLLVQKATEANTDTSDKALKEYYKTWQPDITVSHILVADEKKAKEVEQKLKD
GAKFSDLAKEYSTDTATKENGGQLAAFGPGKMDPAFEKAAYALKNKGDISAPVKTQYGYHIIQMDEPATKTTFDKDKKAV
KASYLTSQLTNENMQKTLKKEFKDANVKVEDKDLKDAFKDFDSSSSEKSSK

Sequences:

>Translated_291_residues
MKKKLILGLVMVMALFSLAACGGGGDVVKTDAGDVTQDELYEAMKDKYGSEFVQQLTFEKVLGDKYKVSDEDVDKKFKEY
KAQYGDQFAAVLAQSGLTEKTFKSQLKYNLLVQKATEANTDTSDKALKEYYKTWQPDITVSHILVADEKKAKEVEQKLKD
GAKFSDLAKEYSTDTATKENGGQLAAFGPGKMDPAFEKAAYALKNKGDISAPVKTQYGYHIIQMDEPATKTTFDKDKKAV
KASYLTSQLTNENMQKTLKKEFKDANVKVEDKDLKDAFKDFDSSSSEKSSK
>Mature_291_residues
MKKKLILGLVMVMALFSLAACGGGGDVVKTDAGDVTQDELYEAMKDKYGSEFVQQLTFEKVLGDKYKVSDEDVDKKFKEY
KAQYGDQFAAVLAQSGLTEKTFKSQLKYNLLVQKATEANTDTSDKALKEYYKTWQPDITVSHILVADEKKAKEVEQKLKD
GAKFSDLAKEYSTDTATKENGGQLAAFGPGKMDPAFEKAAYALKNKGDISAPVKTQYGYHIIQMDEPATKTTFDKDKKAV
KASYLTSQLTNENMQKTLKKEFKDANVKVEDKDLKDAFKDFDSSSSEKSSK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=40.9638554216867, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=93, Percent_Identity=39.7849462365591, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32385; Mature: 32385

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKLILGLVMVMALFSLAACGGGGDVVKTDAGDVTQDELYEAMKDKYGSEFVQQLTFEK
CCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLGDKYKVSDEDVDKKFKEYKAQYGDQFAAVLAQSGLTEKTFKSQLKYNLLVQKATEANT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
DTSDKALKEYYKTWQPDITVSHILVADEKKAKEVEQKLKDGAKFSDLAKEYSTDTATKEN
CCHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
GGQLAAFGPGKMDPAFEKAAYALKNKGDISAPVKTQYGYHIIQMDEPATKTTFDKDKKAV
CCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHH
KASYLTSQLTNENMQKTLKKEFKDANVKVEDKDLKDAFKDFDSSSSEKSSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKKLILGLVMVMALFSLAACGGGGDVVKTDAGDVTQDELYEAMKDKYGSEFVQQLTFEK
CCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLGDKYKVSDEDVDKKFKEYKAQYGDQFAAVLAQSGLTEKTFKSQLKYNLLVQKATEANT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
DTSDKALKEYYKTWQPDITVSHILVADEKKAKEVEQKLKDGAKFSDLAKEYSTDTATKEN
CCHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
GGQLAAFGPGKMDPAFEKAAYALKNKGDISAPVKTQYGYHIIQMDEPATKTTFDKDKKAV
CCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHH
KASYLTSQLTNENMQKTLKKEFKDANVKVEDKDLKDAFKDFDSSSSEKSSK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA