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The map label for this gene is drrC [H]

Identifier: 116873486

GI number: 116873486

Start: 2104763

End: 2107003

Strand: Direct

Name: drrC [H]

Synonym: lwe2070

Alternate gene names: 116873486

Gene position: 2104763-2107003 (Clockwise)

Preceding gene: 116873479

Following gene: 116873494

Centisome position: 74.79

GC content: 37.93

Gene sequence:

>2241_bases
ATGGTACAAGAATATATTCGATTAAGAGGAGCTCGTGAAAACAATCTCCAAAATATTTCCTTAGATATTCCAAAACGAAA
AATCACCATTTTCACTGGAGTGTCTGGATCTGGGAAATCTTCTATTGTATTTGAAACTATCGCCACTGAATCGCAAAGAC
AGTTAAATGAAACTTACAGTGCGTATCTTCGTAATTTTCTTCCGAAGTATGCGCAACCAGATGCGGATTCAATTGAAAAC
CTCTCCACCTCTGTTATTATTGATCAAAAAAGGCTTGGCGGTAACTCCCGCTCCACCCTTGGCACTATCACAGATATTAA
TTCGATTTTACGGTTACTTTTTTCACGTGTAGGTAAACCGAGTATCGGTACAGCAAATCTATTTTCTTTTAATGATCCTG
CTGGTATGTGTCCAGATTGTCATGGTGTTGGTCAAAAAGTCTCGGTTGATTTAGTCAAATTACTCGATCCAAATAAGTCA
CTCCAAGAAGGCGCCATTTTATTTCCGACGTTTTCAGTGGACTCATGGTACTGGAATTCTTATGCTTATTCCGGTTTTTT
TGATGTGAATAAAAAAATAAAAGAGTATACGGATGAAGAATATGACATGCTTTTAAACGGAAAAGATATAAAAGTCTTTC
TGGAAACACCGATGGGTAGCATGAATGCAACATATGAAGGGTTGATTCCAAAATTCAATCGTCTCTACATTCAAAAAGAA
GGCGAAATGTCTGCTTCTACTAAAAAACGCGTAGATAAATTCACCCATATTGCTCCTTGCACAACTTGCGATGGTACGCG
ACTCTCGGAACAAGCACTATCTTGCAAAATAAATGGTTTAACTATCGCCGACTTCACAGCGATGCAATTAGATGAATTAA
AAGAAACCATCGCAAGCATTGATACTACGATCGCCGCTCCAATGATTAAAAGTGTCACAGAACGTTTAGAGCATTTAATT
GATATTGGACTTGGTTATATGACACTTGATCGCCAAACTACTTCTCTTTCTGGTGGTGAATCACAACGTGTCAAAATGAT
TCGTCATTTGAACAGTAGTCTAACAGATTTACTTTATATTTTCGATGAGCCAAGTATTGGTCTTCATCCTCGTGATGTTC
ATCGTCTCAATGAATTACTCATTAAATTGCGCGATAAAGGGAATACTATTCTCGTTGTGGAACATGACCCAGATGTCATC
AAAATTGCTGATCATATTGTCGATGTCGGCCCAGAAGCTGGTAAAAACGGCGGTGAAATCCAGTTCGTTGGAAGTTATGA
AGATTTACTGAAGTCTGATACCCTGACTGGTCGTTTCCTTAATCGACATTTACCAATTAACGATCAACCACGAGCACCAA
AAGGCTTTTTATCAACGGAAAAAAGTAGTCGTTTTAACTTAAAAAATATTCAAGCTAATATTCCAAAAGAAGTACTTACG
GTAATTACTGGCGTGGCAGGTTCCGGAAAAAGCACATTGATTCATTCTGTTTTCCTAAAAGAATATCCAGATGCAATTGT
GATTGATCAATCAGCGGCGCATGCCAATATCCGCTCCAATCCAGCCACTTATACTGGTATTATGGATTCAATTAGAAAAG
CTTTCGGAAAAGAAAATGATGTCAGTCCTTCACTCTTTAGTTACAATTCCAAAGGCGCTTGCGAAAATTGTAAAGGGCTT
GGTTTCACTACTATGGATTTAGCTTTTATGGATTCAATTCGTACACCTTGCGAAGTTTGTCACGGCAAACGATTCCAAGA
TTCCGTTTTAGAATATAAGTTGGACGGGAAATCCATTAGCGATGTATTAGAATTAACGGTTTCAGAGGCGCTTCAATTCT
TTACAGATAAAAAAATATTGAAGAAGATTACAGCAATGACAGAGGTGGGAATTGGCTATGTTACTCTAGGTCAACCACTT
AGCACGCTTTCTGGAGGGGAATGTCAACGTCTAAAACTCGCTAATGAACTGCATAAGAAAGGTTCGATTTATATTATGGA
TGAACCAACCACAGGACTTCATATGTCAGACATCGAGCATATTCTCACTATTATTCACTCGCTTGTAAACAAAGGGAATA
CCGTTATTGTAATTGAACATAATGTTGATATTATCCGAAATGCTGATTGGATTATTGACCTTGGTCCAGAAGGTGGTAGC
GCAGGTGGACAAATTATTTTTGAAGGTGTTCCACTCGATTTACTTAAAAACAACCAATCGTTAACTGCACAATATCTTTA
A

Upstream 100 bases:

>100_bases
ACCATAGCCTCATCCGCTTATCATAAAAGGTTTTTGCTTGACTTTTACAGTCCTACTTTGCTAAGATTTTTGTTCGACTC
AAAAAACAGGAGGTATGTGT

Downstream 100 bases:

>100_bases
TAGAAAAAAAGCTGTTTTGTCTAGACTTAAGACAAAACAGCTTTTTTTATTGTAGTTTTTCTAAATATGACACAGCATCT
TGGAACGTTTTTACAGGAAC

Product: UvrABC system protein A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 746; Mature: 746

Protein sequence:

>746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYAQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LQEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKEYTDEEYDMLLNGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCDGTRLSEQALSCKINGLTIADFTAMQLDELKETIASIDTTIAAPMIKSVTERLEHLI
DIGLGYMTLDRQTTSLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLIKLRDKGNTILVVEHDPDVI
KIADHIVDVGPEAGKNGGEIQFVGSYEDLLKSDTLTGRFLNRHLPINDQPRAPKGFLSTEKSSRFNLKNIQANIPKEVLT
VITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDSIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLEYKLDGKSISDVLELTVSEALQFFTDKKILKKITAMTEVGIGYVTLGQPL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGVPLDLLKNNQSLTAQYL

Sequences:

>Translated_746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYAQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LQEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKEYTDEEYDMLLNGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCDGTRLSEQALSCKINGLTIADFTAMQLDELKETIASIDTTIAAPMIKSVTERLEHLI
DIGLGYMTLDRQTTSLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLIKLRDKGNTILVVEHDPDVI
KIADHIVDVGPEAGKNGGEIQFVGSYEDLLKSDTLTGRFLNRHLPINDQPRAPKGFLSTEKSSRFNLKNIQANIPKEVLT
VITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDSIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLEYKLDGKSISDVLELTVSEALQFFTDKKILKKITAMTEVGIGYVTLGQPL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGVPLDLLKNNQSLTAQYL
>Mature_746_residues
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYSAYLRNFLPKYAQPDADSIEN
LSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKPSIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKS
LQEGAILFPTFSVDSWYWNSYAYSGFFDVNKKIKEYTDEEYDMLLNGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
GEMSASTKKRVDKFTHIAPCTTCDGTRLSEQALSCKINGLTIADFTAMQLDELKETIASIDTTIAAPMIKSVTERLEHLI
DIGLGYMTLDRQTTSLSGGESQRVKMIRHLNSSLTDLLYIFDEPSIGLHPRDVHRLNELLIKLRDKGNTILVVEHDPDVI
KIADHIVDVGPEAGKNGGEIQFVGSYEDLLKSDTLTGRFLNRHLPINDQPRAPKGFLSTEKSSRFNLKNIQANIPKEVLT
VITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDSIRKAFGKENDVSPSLFSYNSKGACENCKGL
GFTTMDLAFMDSIRTPCEVCHGKRFQDSVLEYKLDGKSISDVLELTVSEALQFFTDKKILKKITAMTEVGIGYVTLGQPL
STLSGGECQRLKLANELHKKGSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
AGGQIIFEGVPLDLLKNNQSLTAQYL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=679, Percent_Identity=36.2297496318115, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82474; Mature: 82474

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYS
CCCHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHH
AYLRNFLPKYAQPDADSIENLSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKP
HHHHHHHHHHCCCCCHHHHCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKSLQEGAILFPTFSVDSWYWNS
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHCCEEEEEEECCCCEEECC
YAYSGFFDVNKKIKEYTDEEYDMLLNGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
EEECCEEHHHHHHHHCCCCCHHEEECCCEEEEEEECCCCCCCCCHHHCCCCCEEEEEEEC
GEMSASTKKRVDKFTHIAPCTTCDGTRLSEQALSCKINGLTIADFTAMQLDELKETIASI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEEECCEEEECHHHHHHHHHHHHHHHH
DTTIAAPMIKSVTERLEHLIDIGLGYMTLDRQTTSLSGGESQRVKMIRHLNSSLTDLLYI
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
FDEPSIGLHPRDVHRLNELLIKLRDKGNTILVVEHDPDVIKIADHIVDVGPEAGKNGGEI
ECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
QFVGSYEDLLKSDTLTGRFLNRHLPINDQPRAPKGFLSTEKSSRFNLKNIQANIPKEVLT
EEEECHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
VITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDSIRKAFGKEND
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
VSPSLFSYNSKGACENCKGLGFTTMDLAFMDSIRTPCEVCHGKRFQDSVLEYKLDGKSIS
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHEEEECCCHHH
DVLELTVSEALQFFTDKKILKKITAMTEVGIGYVTLGQPLSTLSGGECQRLKLANELHKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCCCHHHHHHHHHHHHC
GSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEECCCCCC
AGGQIIFEGVPLDLLKNNQSLTAQYL
CCCEEEEECCCHHHHCCCCCEEEECC
>Mature Secondary Structure
MVQEYIRLRGARENNLQNISLDIPKRKITIFTGVSGSGKSSIVFETIATESQRQLNETYS
CCCHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEHHCHHHHHHHHHHH
AYLRNFLPKYAQPDADSIENLSTSVIIDQKRLGGNSRSTLGTITDINSILRLLFSRVGKP
HHHHHHHHHHCCCCCHHHHCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIGTANLFSFNDPAGMCPDCHGVGQKVSVDLVKLLDPNKSLQEGAILFPTFSVDSWYWNS
CCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHCCEEEEEEECCCCEEECC
YAYSGFFDVNKKIKEYTDEEYDMLLNGKDIKVFLETPMGSMNATYEGLIPKFNRLYIQKE
EEECCEEHHHHHHHHCCCCCHHEEECCCEEEEEEECCCCCCCCCHHHCCCCCEEEEEEEC
GEMSASTKKRVDKFTHIAPCTTCDGTRLSEQALSCKINGLTIADFTAMQLDELKETIASI
CCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEEEECCEEEECHHHHHHHHHHHHHHHH
DTTIAAPMIKSVTERLEHLIDIGLGYMTLDRQTTSLSGGESQRVKMIRHLNSSLTDLLYI
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEE
FDEPSIGLHPRDVHRLNELLIKLRDKGNTILVVEHDPDVIKIADHIVDVGPEAGKNGGEI
ECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCCCCEE
QFVGSYEDLLKSDTLTGRFLNRHLPINDQPRAPKGFLSTEKSSRFNLKNIQANIPKEVLT
EEEECHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCHHHHH
VITGVAGSGKSTLIHSVFLKEYPDAIVIDQSAAHANIRSNPATYTGIMDSIRKAFGKEND
HHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
VSPSLFSYNSKGACENCKGLGFTTMDLAFMDSIRTPCEVCHGKRFQDSVLEYKLDGKSIS
CCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHEEEECCCHHH
DVLELTVSEALQFFTDKKILKKITAMTEVGIGYVTLGQPLSTLSGGECQRLKLANELHKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCCCHHHHHHHHHHHHC
GSIYIMDEPTTGLHMSDIEHILTIIHSLVNKGNTVIVIEHNVDIIRNADWIIDLGPEGGS
CCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEECCCCCC
AGGQIIFEGVPLDLLKNNQSLTAQYL
CCCEEEEECCCHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]