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The map label for this gene is gltC [H]

Identifier: 116873168

GI number: 116873168

Start: 1779701

End: 1780588

Strand: Direct

Name: gltC [H]

Synonym: lwe1752

Alternate gene names: 116873168

Gene position: 1779701-1780588 (Clockwise)

Preceding gene: 116873165

Following gene: 116873182

Centisome position: 63.24

GC content: 37.27

Gene sequence:

>888_bases
ATGGAACTTAGACAATTAAAGTATTTCATGGAAGTAGCCCGCGTCGAGCATATGACCAAAGCTAGCGAGAATTTGCACGT
AGCCCAATCTGCCGTTAGTAGACAGATAACGAAACTTGAGGAAGAATTAGGTGTTCCTTTATTTGATCGTGTTGGTCGAA
ATATGCAGCTTACAAGTGTTGGCCAAGATTTCCTAAATCAAGCGGCTATTGCCTTAAATGAATTACAAAAAGCCGAAGCC
CTCGTGACTGAATACACCGACCCCACTCAAGGAACTGTACGTGTTGGTTTACCAAATTCATTATCTACCAAAGTCTTGCC
ATCTGTTATTTCTACTTTTCGAGAAAAATATCCACAAATTACCTACCAATTTATGGAAGGAACAAATGAAGAACTTACCG
AAATGCTTGTAAATGGTGTACTTGACATGACTTTCCTCTCACCTGTCCCTGAATCTAATGAACAAATCGAAGCTATCCGT
TTTTTTGATGAAAAGTTGAAATTAATCGTTCCAACAACCCATCCACTTGCAGAAAACTTCAATGTGTCACTCAAAGAACT
CGCCAATGAAAAATTCGTACTCTATCCAGAAGACTTTGATTTATATAAAATTGTTACGAAAGCAGCAAATAAAAAAGGCT
TTGAACCACAAATTGCCTTTCAAAGTAGAGATTTTTATACCATTCAGGGTTTAGTTGGAGCAGGACTTGGTATTAGCATT
TTACCAGAAATGATTTTGGATGGTGCCATTTTTAAAGAAACGAAAAGTATTGTTTTGCGCGACAAAGAATTGCGACGTTC
GGTTGGAATTATTACAACCAAAAAACGGAACCTATCCCCTTCTGAGAATTTGTTCCGTTCTTTTATTATTTCATTCTTTT
CCCATTAA

Upstream 100 bases:

>100_bases
TACATTTCTTGTAGTATCTATTTTATTCCTTTTCATTTATCGAAACAATATATATAATAGAATAAAACAATCTCATTTCG
AGAACAATCGGAGGTAAGTA

Downstream 100 bases:

>100_bases
TTATTTTCCGAAAAAGCAGCTGGATAATGAATTGTTCCTGCTAGATTTTCCAAACTACCATCATATAATTCTAACAACAT
AAAATATTCAGCAGGTACAT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVPLFDRVGRNMQLTSVGQDFLNQAAIALNELQKAEA
LVTEYTDPTQGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLVNGVLDMTFLSPVPESNEQIEAIR
FFDEKLKLIVPTTHPLAENFNVSLKELANEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIVLRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSH

Sequences:

>Translated_295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVPLFDRVGRNMQLTSVGQDFLNQAAIALNELQKAEA
LVTEYTDPTQGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLVNGVLDMTFLSPVPESNEQIEAIR
FFDEKLKLIVPTTHPLAENFNVSLKELANEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIVLRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSH
>Mature_295_residues
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVPLFDRVGRNMQLTSVGQDFLNQAAIALNELQKAEA
LVTEYTDPTQGTVRVGLPNSLSTKVLPSVISTFREKYPQITYQFMEGTNEELTEMLVNGVLDMTFLSPVPESNEQIEAIR
FFDEKLKLIVPTTHPLAENFNVSLKELANEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
LPEMILDGAIFKETKSIVLRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSH

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=33.0578512396694, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787879, Length=301, Percent_Identity=31.2292358803987, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=27.7978339350181, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=27.4900398406374, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=30.4526748971193, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=29.5081967213115, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693105, Length=294, Percent_Identity=27.891156462585, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788481, Length=288, Percent_Identity=28.8194444444444, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787601, Length=247, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788297, Length=302, Percent_Identity=25.1655629139073, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790262, Length=252, Percent_Identity=25.3968253968254, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788748, Length=280, Percent_Identity=27.8571428571429, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790208, Length=285, Percent_Identity=23.5087719298246, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=24.4979919678715, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367136, Length=264, Percent_Identity=23.1060606060606, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=30.6532663316583, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786401, Length=261, Percent_Identity=24.5210727969349, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=22.8187919463087, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789639, Length=283, Percent_Identity=21.5547703180212, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789204, Length=252, Percent_Identity=21.4285714285714, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI48994962, Length=78, Percent_Identity=42.3076923076923, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790783, Length=276, Percent_Identity=25, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33433; Mature: 33433

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVPLFDRVGRNMQLTSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHH
GQDFLNQAAIALNELQKAEALVTEYTDPTQGTVRVGLPNSLSTKVLPSVISTFREKYPQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
TYQFMEGTNEELTEMLVNGVLDMTFLSPVPESNEQIEAIRFFDEKLKLIVPTTHPLAENF
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHHCC
NVSLKELANEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
CCCHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEHHHHHCCCCHHH
LPEMILDGAIFKETKSIVLRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSH
HHHHHHCCHHHHHHHHHHHCCHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELRQLKYFMEVARVEHMTKASENLHVAQSAVSRQITKLEEELGVPLFDRVGRNMQLTSV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEHHH
GQDFLNQAAIALNELQKAEALVTEYTDPTQGTVRVGLPNSLSTKVLPSVISTFREKYPQI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
TYQFMEGTNEELTEMLVNGVLDMTFLSPVPESNEQIEAIRFFDEKLKLIVPTTHPLAENF
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEEEECCCCCHHHCC
NVSLKELANEKFVLYPEDFDLYKIVTKAANKKGFEPQIAFQSRDFYTIQGLVGAGLGISI
CCCHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEECCCCCEEEHHHHHCCCCHHH
LPEMILDGAIFKETKSIVLRDKELRRSVGIITTKKRNLSPSENLFRSFIISFFSH
HHHHHHCCHHHHHHHHHHHCCHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]