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The map label for this gene is gsaB [H]

Identifier: 116873119

GI number: 116873119

Start: 1726437

End: 1727735

Strand: Direct

Name: gsaB [H]

Synonym: lwe1703

Alternate gene names: 116873119

Gene position: 1726437-1727735 (Clockwise)

Preceding gene: 116873111

Following gene: 116873120

Centisome position: 61.35

GC content: 38.88

Gene sequence:

>1299_bases
ATGGATCATTCAATGTCAAAAAAATTGCATGACGAAGCACTTTTACATATAGTTGGTGGGGTTAATAGCCCATCTAGGTC
AAACAAAGGAGTTGGCGGTGGAATTCCTGTCACAATGGAACGAGCAAATGGTGCTTATTTTTATGATGTGGATGGAAATA
AATATATTGACTATTTAGCTGCATTTGGACCGATTATTACTGGACATGCGCATCCTCATATTACAGAAGCAATTACAAAA
GCGGCGCAAAATGGCGTTTTGTACGGAACACCTACAAAACATGAAATAACCTTTGCAAAAATGTTAAAAGAAGCAATTCC
TTCTCTTGAAAAAGTTCGATTTACAAACTCCGGCACAGAAGCTGTTATGACAACTATTCGTGTAGCTCGTGCTTATACGG
GACGAGACAAAATCATTAAATTTGCCGGATGCTACCATGGACATTTTGATTTAGTATTAGTTGAAGCTGGCTCTGGGCCA
TCTACACTAGGAATTCCAGATTCTGCTGGTGTGACAAAATCGACTGCCGAGGAAGTTATTACAGTACCTTTTAATGACCT
TGCATCCTTCAAAGAAGCATTAGCTACTTGGGGAAATCAAGTTGCAGCAGTTTTAGTAGAACCTATTGTTGGAAACTTTG
GAATGGTTGAGCCTGCTGAAGGATTTCTAGAAGCTATTAATGAACTTGCACATGAAAATGGCTCTTTAGTAATTTATGAT
GAAGTTATCACAGCTTTCCGTTTTATGTACGGTGGAGCTCAGAATTATTTAGGTGTTATTCCCGACTTAACAGCTATGGG
TAAAATTATTGGCGGAGGTCTTCCAATAGGTGCTTACGGCGGACGAATAGATATTATGGAAAAAGTAGCACCTTTAGGAC
CCGCATATCAAGCTGGAACACACGCAGGTAATCCAGCTTCCATTTTATCAGGTATCGCTTGTCTTGAAGTTTTACAAGAA
GAAGGACTTTATGATCGCTTTCAAAAATATGGCTCCATGTTAAAAGATGGAATTGAAAAAGCCGCTGTGAAACATGGTAT
TGCAGTAACGGTTAACCAAATTGTTGGCGCTCTAACTGTTTACTTTACAGATGAACCAGTGACTAATTATGCAGAAGCTG
GAGCTACAAATGGTGATTTATTCGGTCGTTTCTTCAAAGGTATGTTAGAAGAGGGTATTAACCTAGCGCCTTCCAAATAT
GAAGCATGGTTCATTACCTCCGCACATTCTGAAGCAGATATTTTAGAAACTATTCAAGCAGTCGATACAGTTTTTGCAAA
AATGGTTCAAGATAAATAG

Upstream 100 bases:

>100_bases
TTTTTTTCATTTGTCGGCAATTATATTGTTTTTTCAATTGCGACTTCTCATTTTTTCGCATAGAATATAGAAGGTATTAA
ATTATTGAGGAGATGACGAA

Downstream 100 bases:

>100_bases
GTATTATTGCTTTATAAACTGACGATAAACGTTATAATAGAAGAAGAATGAGCGGGAATAGTTCAATATCCCGCTCAAAT
AGTCTATAGAAAGGAATAAC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLAAFGPIITGHAHPHITEAITK
AAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGP
STLGIPDSAGVTKSTAEEVITVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYD
EVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGTHAGNPASILSGIACLEVLQE
EGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTVYFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKY
EAWFITSAHSEADILETIQAVDTVFAKMVQDK

Sequences:

>Translated_432_residues
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLAAFGPIITGHAHPHITEAITK
AAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGP
STLGIPDSAGVTKSTAEEVITVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYD
EVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGTHAGNPASILSGIACLEVLQE
EGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTVYFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKY
EAWFITSAHSEADILETIQAVDTVFAKMVQDK
>Mature_432_residues
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLAAFGPIITGHAHPHITEAITK
AAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTEAVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGP
STLGIPDSAGVTKSTAEEVITVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYD
EVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGTHAGNPASILSGIACLEVLQE
EGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTVYFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKY
EAWFITSAHSEADILETIQAVDTVFAKMVQDK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=351, Percent_Identity=30.4843304843305, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=28.1899109792285, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI37574042, Length=339, Percent_Identity=26.8436578171091, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=340, Percent_Identity=28.2352941176471, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226442705, Length=340, Percent_Identity=26.7647058823529, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=307, Percent_Identity=27.0358306188925, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI284507298, Length=260, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=48.3568075117371, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1789016, Length=342, Percent_Identity=29.8245614035088, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787560, Length=361, Percent_Identity=29.9168975069252, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693181, Length=372, Percent_Identity=28.2258064516129, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789759, Length=318, Percent_Identity=28.9308176100629, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788044, Length=287, Percent_Identity=31.0104529616725, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786991, Length=383, Percent_Identity=23.7597911227154, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144271, Length=317, Percent_Identity=27.7602523659306, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=27.5147928994083, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=328, Percent_Identity=29.5731707317073, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=156, Percent_Identity=33.974358974359, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=393, Percent_Identity=28.2442748091603, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357415, Length=315, Percent_Identity=30.1587301587302, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161085790, Length=344, Percent_Identity=28.7790697674419, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574759, Length=344, Percent_Identity=28.7790697674419, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46100; Mature: 46100

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHH
AFGPIITGHAHPHITEAITKAAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTE
HHCCHHCCCCCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCHHHHEEECCCCHH
AVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGPSTLGIPDSAGVTKSTAEEVI
HHHHHHHHHHHHCCHHHHEEEECEECCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCEE
TVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYD
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEH
EVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGT
HHHHHHHHHHCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHCCC
HAGNPASILSGIACLEVLQEEGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCEEEE
YFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKYEAWFITSAHSEADILETIQA
EECCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VDTVFAKMVQDK
HHHHHHHHHHCC
>Mature Secondary Structure
MDHSMSKKLHDEALLHIVGGVNSPSRSNKGVGGGIPVTMERANGAYFYDVDGNKYIDYLA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHH
AFGPIITGHAHPHITEAITKAAQNGVLYGTPTKHEITFAKMLKEAIPSLEKVRFTNSGTE
HHCCHHCCCCCCHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCHHHHEEECCCCHH
AVMTTIRVARAYTGRDKIIKFAGCYHGHFDLVLVEAGSGPSTLGIPDSAGVTKSTAEEVI
HHHHHHHHHHHHCCHHHHEEEECEECCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHCEE
TVPFNDLASFKEALATWGNQVAAVLVEPIVGNFGMVEPAEGFLEAINELAHENGSLVIYD
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEH
EVITAFRFMYGGAQNYLGVIPDLTAMGKIIGGGLPIGAYGGRIDIMEKVAPLGPAYQAGT
HHHHHHHHHHCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHCCC
HAGNPASILSGIACLEVLQEEGLYDRFQKYGSMLKDGIEKAAVKHGIAVTVNQIVGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHCEEEE
YFTDEPVTNYAEAGATNGDLFGRFFKGMLEEGINLAPSKYEAWFITSAHSEADILETIQA
EECCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VDTVFAKMVQDK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA