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The map label for this gene is menA [H]

Identifier: 116873111

GI number: 116873111

Start: 1708498

End: 1709436

Strand: Direct

Name: menA [H]

Synonym: lwe1695

Alternate gene names: 116873111

Gene position: 1708498-1709436 (Clockwise)

Preceding gene: 116873105

Following gene: 116873119

Centisome position: 60.71

GC content: 37.49

Gene sequence:

>939_bases
ATGGCTAATGCCTCAAAATCTGCACTTACAAAACAAACTGGATTCCAGAAATGGTGGTCACTACTTCGCCCCCATACACT
TGTAGCCTCTTTTGTTCCGGTTTTCCTTGGAACATCTGTTGCAATGAGCTACACCAGCTTTAACTTTACACGTTTTATCG
TCATGCTAATTGCTTGTTTCTTTATACAAACATCGGCCAATCTATTCAATGAATATTTTGATTATAAAAAAGGACAAGAT
GATGAGCATTCGGTTGGAAATGGTGGTGCTATTGTTCGTAATGGTATGCGACCAGGTTTTATTTTGTTCCTAGCAATCTT
TTTATACATTTTATCTATTCTTGGTGGAGTTTATTTATCCATCGAACTTAATTGGTATGTTGGTTTACTTGGCGCAATTT
GTATGCTTGTTGGTTTCCTTTATACAGGCGGACCTTATCCGATTGCTTATACGCCTTTTGGTGAAATTATGGCGGGATTC
TTTATGGGTGGAATTATTACATTCATTTCCTTCTATATTCAAGCAGAATTCATTAGTTCATTTATCGTATATGTTTCAAT
TCCAGTAATGGTACTCGTTGGTAACTTACTACTTGCCAACAGCATTCGCGATTTAGTGCCTGATAAGAAAAATGGGCGTT
TGACTTTAGCTATCTTACTTGGTCGGAAATGGGCCATTGTTCTTTTTGCAGCAGCCTTTCTTTTCAGTTATGTATTTGAA
ATCGCCCTAATTTTTACACAAGATGCTCCGTGGTGGACACTCTTAATTTTACTTAGTTTGCCAGAAGCCATTCGCGCTGT
GCGTCGTTTTGTTGGTAAAACTTCGCCAATCACAATGGTTCCGGCAATGAAATCCACTTCCAAAGCATTAACGATTTTTG
GAATTACACTTGCAATTGCGTATCTATTAAGCCTACTATCTAGAAATTTATTCATGTAA

Upstream 100 bases:

>100_bases
TTCCTCCTTTTCGTTATTAATTATTGACGTACTTACAATATTTCCCTAAAATGAAGGGTAGACATCTGAAACACATGGAA
GTGAAAAAGGAGAGAAAATC

Downstream 100 bases:

>100_bases
AAAAACTGGTTGTCACAATGACAACCAGTTTTTTATTTGGAGATGATTTCAACCTGCTGTTTTTTTTGAATGTATTTTGC
AAGTTCCACCGATAAATCAT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MANASKSALTKQTGFQKWWSLLRPHTLVASFVPVFLGTSVAMSYTSFNFTRFIVMLIACFFIQTSANLFNEYFDYKKGQD
DEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGF
FMGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWAIVLFAAAFLFSYVFE
IALIFTQDAPWWTLLILLSLPEAIRAVRRFVGKTSPITMVPAMKSTSKALTIFGITLAIAYLLSLLSRNLFM

Sequences:

>Translated_312_residues
MANASKSALTKQTGFQKWWSLLRPHTLVASFVPVFLGTSVAMSYTSFNFTRFIVMLIACFFIQTSANLFNEYFDYKKGQD
DEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGF
FMGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWAIVLFAAAFLFSYVFE
IALIFTQDAPWWTLLILLSLPEAIRAVRRFVGKTSPITMVPAMKSTSKALTIFGITLAIAYLLSLLSRNLFM
>Mature_311_residues
ANASKSALTKQTGFQKWWSLLRPHTLVASFVPVFLGTSVAMSYTSFNFTRFIVMLIACFFIQTSANLFNEYFDYKKGQDD
EHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFF
MGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWAIVLFAAAFLFSYVFEI
ALIFTQDAPWWTLLILLSLPEAIRAVRRFVGKTSPITMVPAMKSTSKALTIFGITLAIAYLLSLLSRNLFM

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=316, Percent_Identity=27.2151898734177, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1790365, Length=285, Percent_Identity=27.0175438596491, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737429, Length=290, Percent_Identity=28.9655172413793, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34701; Mature: 34570

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANASKSALTKQTGFQKWWSLLRPHTLVASFVPVFLGTSVAMSYTSFNFTRFIVMLIACF
CCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQTSANLFNEYFDYKKGQDDEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEEEE
IELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFFMGGIITFISFYIQAEFISS
EEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWAIVLFAAAFLFSYVFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
IALIFTQDAPWWTLLILLSLPEAIRAVRRFVGKTSPITMVPAMKSTSKALTIFGITLAIA
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
YLLSLLSRNLFM
HHHHHHHHHCCC
>Mature Secondary Structure 
ANASKSALTKQTGFQKWWSLLRPHTLVASFVPVFLGTSVAMSYTSFNFTRFIVMLIACF
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQTSANLFNEYFDYKKGQDDEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEEEE
IELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFFMGGIITFISFYIQAEFISS
EEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWAIVLFAAAFLFSYVFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
IALIFTQDAPWWTLLILLSLPEAIRAVRRFVGKTSPITMVPAMKSTSKALTIFGITLAIA
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
YLLSLLSRNLFM
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]