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The map label for this gene is yclK [H]

Identifier: 116872937

GI number: 116872937

Start: 1515919

End: 1517358

Strand: Direct

Name: yclK [H]

Synonym: lwe1521

Alternate gene names: 116872937

Gene position: 1515919-1517358 (Clockwise)

Preceding gene: 116872936

Following gene: 116872944

Centisome position: 53.87

GC content: 33.68

Gene sequence:

>1440_bases
ATGAAGCGAATGAAATTTAAATATGCTTATCAACTTTTTTTCACACAATTTATCATCTTGCTCATTGCTTGTATTATGAT
TGGGGTGTTAGTCTCCCATTCATTAAAAGATTATTTTTATCAAAGCCAAGTAGATGATTTAACTAGTTATGGTGAAACAA
TTTCAATGGATATCAGGCATTCCCCTCAAGATGCAACCGTCCAAGTACTTAATACCTACCAACGTATTTTAGATGTGAAA
AAAATTCATTACACCATCAAAAATGCAGATGATGAAACGATTTATCCAACTCAAATGAATCAGCCCTTACCAAAAGATTT
CTCCATTTCTAAAGATGATAAAAAGAAATTAAAAAGCGGCGAAACGGTCAGCAAAAAAATCGATAATCGTTTTAACCGTG
AAATGACAATTGTCTATGTGCCAATCATGAACGGGGATAAATTTGTTGGTTCTATCGTCTTAAATTCTCCAATTAGTGGA
ACAGAGCAAGTGATAGGAACCATAAATCGTTATATGTTCTATACTATTTTACTTTCAATTACGATAGCACTTATTTTGAG
TGCCATTCTGTCTAAGCTTCAAGTTAATCGTATCAATAAATTACGATCTGCGACCAAAGACGTTATCCAAGGTAATTATA
AAGCACGTCTAAAAGAAAATAATTTTGATGAGATTGGCGCGCTTGCTATTGATTTTAATAAAATGACGCAAACGCTTGAA
AAGTCTCAAGAAGAAATCGAACGTCAAGAAAAGCGGCGCCGTCAGTTTATCGCGGATGTTTCTCATGAGATGCGTACCCC
ACTGACTACGATCAGCGGTGTGACAGAGGGATTAGTAAATGATATTATTCCAAAAAGTGAAACGGATCGTTGTATTGCAC
TCATTGATACAGAAGCAAAACGATTAACAAAATTGGTCAATGAAAATCTTGATTATGAAAAAATAAGAAGTAATAAAATC
AAACTACAAAAAACTCGTTTTAACGGTCGAGAATTTTTAGAGTTAATCAAAGAACAACTAGATTATGTAGCAACCGAAAA
AGGCAATACTATTACAGTAAATATTGATCAGGATATGAATATCTATGCTGATTATGACCGATTAACACAAGTTTTTATTA
ATATTGTTAAAAACAGTGTGCAGTTTACCGAAAATGGTCAAATTACATTAACTGGTACGCAAGACTATAAAGAATCTGTA
TTAACTATCACGGATACGGGAATCGGCATGAATACAGAAGAATTGGAACAAATTTGGGAACGATTTTATAAAGCAGATAT
GTCCCGAACAAATACAGCTTTTGGGGAATCAGGAATTGGTCTCTCTATTGTGAAGCAGTTAATTGAGTATCATGATGGAA
CAATTAGCGTTACAAGTAAGCCAAATGAAGGCACTACATTTACTATTCGCTTACCGTTTTTCCAAGATAATGAACAGTAA

Upstream 100 bases:

>100_bases
TGGATGTTCATATTAAACGTTTACGCCAAAAAATTGCCACAGATACGAAGCCGTTTTTACACACTGTTTGGGGTGTGGGC
TACAAATTTGATGAAACGGA

Downstream 100 bases:

>100_bases
AAAAACACCCACTTGCGAGTGGGTGTTTTTCATCCTACCATAAATTGTTCTGGGGTAATCCCTTCCATTCCAATCATAGG
ATCAATTTCTGTAATATTTT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKRMKFKYAYQLFFTQFIILLIACIMIGVLVSHSLKDYFYQSQVDDLTSYGETISMDIRHSPQDATVQVLNTYQRILDVK
KIHYTIKNADDETIYPTQMNQPLPKDFSISKDDKKKLKSGETVSKKIDNRFNREMTIVYVPIMNGDKFVGSIVLNSPISG
TEQVIGTINRYMFYTILLSITIALILSAILSKLQVNRINKLRSATKDVIQGNYKARLKENNFDEIGALAIDFNKMTQTLE
KSQEEIERQEKRRRQFIADVSHEMRTPLTTISGVTEGLVNDIIPKSETDRCIALIDTEAKRLTKLVNENLDYEKIRSNKI
KLQKTRFNGREFLELIKEQLDYVATEKGNTITVNIDQDMNIYADYDRLTQVFINIVKNSVQFTENGQITLTGTQDYKESV
LTITDTGIGMNTEELEQIWERFYKADMSRTNTAFGESGIGLSIVKQLIEYHDGTISVTSKPNEGTTFTIRLPFFQDNEQ

Sequences:

>Translated_479_residues
MKRMKFKYAYQLFFTQFIILLIACIMIGVLVSHSLKDYFYQSQVDDLTSYGETISMDIRHSPQDATVQVLNTYQRILDVK
KIHYTIKNADDETIYPTQMNQPLPKDFSISKDDKKKLKSGETVSKKIDNRFNREMTIVYVPIMNGDKFVGSIVLNSPISG
TEQVIGTINRYMFYTILLSITIALILSAILSKLQVNRINKLRSATKDVIQGNYKARLKENNFDEIGALAIDFNKMTQTLE
KSQEEIERQEKRRRQFIADVSHEMRTPLTTISGVTEGLVNDIIPKSETDRCIALIDTEAKRLTKLVNENLDYEKIRSNKI
KLQKTRFNGREFLELIKEQLDYVATEKGNTITVNIDQDMNIYADYDRLTQVFINIVKNSVQFTENGQITLTGTQDYKESV
LTITDTGIGMNTEELEQIWERFYKADMSRTNTAFGESGIGLSIVKQLIEYHDGTISVTSKPNEGTTFTIRLPFFQDNEQ
>Mature_479_residues
MKRMKFKYAYQLFFTQFIILLIACIMIGVLVSHSLKDYFYQSQVDDLTSYGETISMDIRHSPQDATVQVLNTYQRILDVK
KIHYTIKNADDETIYPTQMNQPLPKDFSISKDDKKKLKSGETVSKKIDNRFNREMTIVYVPIMNGDKFVGSIVLNSPISG
TEQVIGTINRYMFYTILLSITIALILSAILSKLQVNRINKLRSATKDVIQGNYKARLKENNFDEIGALAIDFNKMTQTLE
KSQEEIERQEKRRRQFIADVSHEMRTPLTTISGVTEGLVNDIIPKSETDRCIALIDTEAKRLTKLVNENLDYEKIRSNKI
KLQKTRFNGREFLELIKEQLDYVATEKGNTITVNIDQDMNIYADYDRLTQVFINIVKNSVQFTENGQITLTGTQDYKESV
LTITDTGIGMNTEELEQIWERFYKADMSRTNTAFGESGIGLSIVKQLIEYHDGTISVTSKPNEGTTFTIRLPFFQDNEQ

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=30.7142857142857, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=30.4526748971193, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1789149, Length=333, Percent_Identity=27.9279279279279, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=30.672268907563, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=30.6201550387597, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081816, Length=273, Percent_Identity=26.3736263736264, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=27.5109170305677, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=29.0780141843972, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=28.448275862069, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790861, Length=417, Percent_Identity=23.5011990407674, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=463, Percent_Identity=23.9740820734341, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=26, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788279, Length=310, Percent_Identity=24.5161290322581, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=279, Percent_Identity=27.9569892473118, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=24.2553191489362, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790300, Length=265, Percent_Identity=26.0377358490566, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55095; Mature: 55095

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRMKFKYAYQLFFTQFIILLIACIMIGVLVSHSLKDYFYQSQVDDLTSYGETISMDIRH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
SPQDATVQVLNTYQRILDVKKIHYTIKNADDETIYPTQMNQPLPKDFSISKDDKKKLKSG
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
ETVSKKIDNRFNREMTIVYVPIMNGDKFVGSIVLNSPISGTEQVIGTINRYMFYTILLSI
CHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
TIALILSAILSKLQVNRINKLRSATKDVIQGNYKARLKENNFDEIGALAIDFNKMTQTLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHEEEEEHHHHHHHHH
KSQEEIERQEKRRRQFIADVSHEMRTPLTTISGVTEGLVNDIIPKSETDRCIALIDTEAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHH
RLTKLVNENLDYEKIRSNKIKLQKTRFNGREFLELIKEQLDYVATEKGNTITVNIDQDMN
HHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
IYADYDRLTQVFINIVKNSVQFTENGQITLTGTQDYKESVLTITDTGIGMNTEELEQIWE
EEECHHHHHHHHHHHHHHCCEEECCCEEEEEECHHHHCCEEEEEECCCCCCHHHHHHHHH
RFYKADMSRTNTAFGESGIGLSIVKQLIEYHDGTISVTSKPNEGTTFTIRLPFFQDNEQ
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKRMKFKYAYQLFFTQFIILLIACIMIGVLVSHSLKDYFYQSQVDDLTSYGETISMDIRH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
SPQDATVQVLNTYQRILDVKKIHYTIKNADDETIYPTQMNQPLPKDFSISKDDKKKLKSG
CCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCC
ETVSKKIDNRFNREMTIVYVPIMNGDKFVGSIVLNSPISGTEQVIGTINRYMFYTILLSI
CHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
TIALILSAILSKLQVNRINKLRSATKDVIQGNYKARLKENNFDEIGALAIDFNKMTQTLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHEEEEEHHHHHHHHH
KSQEEIERQEKRRRQFIADVSHEMRTPLTTISGVTEGLVNDIIPKSETDRCIALIDTEAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHH
RLTKLVNENLDYEKIRSNKIKLQKTRFNGREFLELIKEQLDYVATEKGNTITVNIDQDMN
HHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
IYADYDRLTQVFINIVKNSVQFTENGQITLTGTQDYKESVLTITDTGIGMNTEELEQIWE
EEECHHHHHHHHHHHHHHCCEEECCCEEEEEECHHHHCCEEEEEECCCCCCHHHHHHHHH
RFYKADMSRTNTAFGESGIGLSIVKQLIEYHDGTISVTSKPNEGTTFTIRLPFFQDNEQ
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]