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The map label for this gene is lisK [H]

Identifier: 116872810

GI number: 116872810

Start: 1382166

End: 1383617

Strand: Direct

Name: lisK [H]

Synonym: lwe1394

Alternate gene names: 116872810

Gene position: 1382166-1383617 (Clockwise)

Preceding gene: 116872809

Following gene: 116872814

Centisome position: 49.12

GC content: 34.3

Gene sequence:

>1452_bases
ATGACAACTAGCCCATTCTCCTTAAAAAGTCGTTCTTTGAAATTCAAATGGACTTTTGGAGCTAGTGCAGCCATTTTTCT
AACCTTTTTCTTATTTTCCTATGCGATTTACCAAGGGATTGGGCAAATGTTGCTAAATGAAGAAGAACCAGAAGTAAAAG
AGTTGCTTCTAGCTACAACAAGTACATTGACTAATCAGGATTTAAGCGACAATGAGGAAATTAAATATTTATTTAATAAT
GACAAAACAGTAAATCGAAAACTGCAAGATCAAGTAATTAATCTATACGATAAAGATGGCCATTTTATTAATAAATATTA
TTTTTCTAGAAATCAAGATATTACGAGTATAGATTTTTCACAGTATTTTGTTAGTGGGACCGACAAGTTTATTATGAATA
AGCCGACAATTGATGGTCAGAAAATGATGACAGCACAAATGCCAATAGTTTCTGACGATAATACAACAGTGATTGGTTAT
GCACAAGTCGTCAATCCGCTAACTTCTTATAATCGAATGATGGATCGTTTACTTGTTACCATGATTTTACTTGGAGCAGT
GGCGCTGTTAATTAGTGGAATGCTTGGCTATTTGCTGGCACAAAATTTCTTAAATCCACTTACTCGTTTGGCACGAACCA
TGAATGATATCCGTAAAAATGGTTTCCAAAAAAGAATTGAAACGAAAACAAACTCTAGAGATGAAATTGGTGAATTAACA
GTCGTTTTCAATGATATGATGACACGAATTGAAACTAGTTTTGAGCAACAAAAACAATTTGTTGAAGATGCATCGCATGA
ATTACGGACGCCGGTCCAAATTATGGAAGGGCATTTAAAACTTCTAACTCGTTGGGGCAAAGATGATCCGGCAGTGCTTG
ATGAATCACTTAATGCTTCTTTAACAGAATTAGAACGAATGAAAAAACTAGTTCAAGAAATGCTCGATTTATCAAGAGCT
GAACAAATTTCGCAAACAAAAGAATTACAGATTACTGATGTCAATGCAATAGTGGAACAAGTAAGACGCAACTTTGAAGT
AATGTATGAACACTTTACCTTTAAATTAAAAGAAGATGATACGGACCTTCGAGCGCTTATTCAACATAATCATTTGGAAC
AAATTTTAATTATTATTATGGATAATGCGGTGAAATATTCAGGCGATGGAACAGAAGTGGATTTACATGTTTATAAAGAG
CAAAAACAAATTCACATTGATGTGCGTGATTACGGTGAAGGTATTTCGCAGGAAGAAATTGATAAAATCTTTAATCGTTT
TTACCGAGTAGACAAAGCTAGAAGCCGTGAAAAAGGCGGAAATGGTCTTGGACTTGCCATCGCCAAACAATTAGTGGAAG
GATATTTAGGAACAATAAATGCGGTTAGTGAGCCAGATAAAGGCACAACTATCAAAATTACACTTCCTTATATTGATCCA
AAATCCAAATAG

Upstream 100 bases:

>100_bases
TAGTTGACGTTTATGTACGTTATTTACGTAATAAAATTGATCATCCTGACGAAGAGAGTTATATCCAAACTGTTCGCGGG
ACTGGGTATGTGATGCGTAC

Downstream 100 bases:

>100_bases
AAAAACCGCAACCTTGTGAAGAGGTTGCGGTTTCTTTTATTTTTCTTTATTTTGTTCATCGACAATTTGCTCAAATTCTT
TTTCTTCTTGCTCCATTACT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATTSTLTNQDLSDNEEIKYLFNN
DKTVNRKLQDQVINLYDKDGHFINKYYFSRNQDITSIDFSQYFVSGTDKFIMNKPTIDGQKMMTAQMPIVSDDNTTVIGY
AQVVNPLTSYNRMMDRLLVTMILLGAVALLISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELT
VVFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNASLTELERMKKLVQEMLDLSRA
EQISQTKELQITDVNAIVEQVRRNFEVMYEHFTFKLKEDDTDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDLHVYKE
QKQIHIDVRDYGEGISQEEIDKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIDP
KSK

Sequences:

>Translated_483_residues
MTTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATTSTLTNQDLSDNEEIKYLFNN
DKTVNRKLQDQVINLYDKDGHFINKYYFSRNQDITSIDFSQYFVSGTDKFIMNKPTIDGQKMMTAQMPIVSDDNTTVIGY
AQVVNPLTSYNRMMDRLLVTMILLGAVALLISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELT
VVFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNASLTELERMKKLVQEMLDLSRA
EQISQTKELQITDVNAIVEQVRRNFEVMYEHFTFKLKEDDTDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDLHVYKE
QKQIHIDVRDYGEGISQEEIDKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIDP
KSK
>Mature_482_residues
TTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATTSTLTNQDLSDNEEIKYLFNND
KTVNRKLQDQVINLYDKDGHFINKYYFSRNQDITSIDFSQYFVSGTDKFIMNKPTIDGQKMMTAQMPIVSDDNTTVIGYA
QVVNPLTSYNRMMDRLLVTMILLGAVALLISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELTV
VFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNASLTELERMKKLVQEMLDLSRAE
QISQTKELQITDVNAIVEQVRRNFEVMYEHFTFKLKEDDTDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDLHVYKEQ
KQIHIDVRDYGEGISQEEIDKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIDPK
SK

Specific function: Member of the two-component regulatory system ArlS/ArlR. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=27.3381294964029, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=31.858407079646, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790346, Length=300, Percent_Identity=29.3333333333333, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=312, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788713, Length=282, Percent_Identity=26.9503546099291, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=370, Percent_Identity=24.8648648648649, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=27.4261603375527, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788279, Length=312, Percent_Identity=25, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.0491803278689, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=26.0504201680672, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=25.6410256410256, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=304, Percent_Identity=25.6578947368421, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=27.1186440677966, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789403, Length=278, Percent_Identity=24.1007194244604, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=26.8595041322314, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=310, Percent_Identity=23.2258064516129, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=290, Percent_Identity=23.7931034482759, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=24.537037037037, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=23.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=287, Percent_Identity=23.3449477351916, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55486; Mature: 55355

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATT
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
STLTNQDLSDNEEIKYLFNNDKTVNRKLQDQVINLYDKDGHFINKYYFSRNQDITSIDFS
HHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEHH
QYFVSGTDKFIMNKPTIDGQKMMTAQMPIVSDDNTTVIGYAQVVNPLTSYNRMMDRLLVT
HHHHCCCCCEEECCCCCCCCHHHEEECCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MILLGAVALLISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VVFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCH
LTELERMKKLVQEMLDLSRAEQISQTKELQITDVNAIVEQVRRNFEVMYEHFTFKLKEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCC
TDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDLHVYKEQKQIHIDVRDYGEGISQEEI
HHHHHHHHHCCHHHHHHEEECCCEEECCCCCEEEEEEEECCCEEEEEHHHHCCCCCHHHH
DKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIDP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
KSK
CCC
>Mature Secondary Structure 
TTSPFSLKSRSLKFKWTFGASAAIFLTFFLFSYAIYQGIGQMLLNEEEPEVKELLLATT
CCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
STLTNQDLSDNEEIKYLFNNDKTVNRKLQDQVINLYDKDGHFINKYYFSRNQDITSIDFS
HHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEHH
QYFVSGTDKFIMNKPTIDGQKMMTAQMPIVSDDNTTVIGYAQVVNPLTSYNRMMDRLLVT
HHHHCCCCCEEECCCCCCCCHHHEEECCEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MILLGAVALLISGMLGYLLAQNFLNPLTRLARTMNDIRKNGFQKRIETKTNSRDEIGELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VVFNDMMTRIETSFEQQKQFVEDASHELRTPVQIMEGHLKLLTRWGKDDPAVLDESLNAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCH
LTELERMKKLVQEMLDLSRAEQISQTKELQITDVNAIVEQVRRNFEVMYEHFTFKLKEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHEEEECCCC
TDLRALIQHNHLEQILIIIMDNAVKYSGDGTEVDLHVYKEQKQIHIDVRDYGEGISQEEI
HHHHHHHHHCCHHHHHHEEECCCEEECCCCCEEEEEEEECCCEEEEEHHHHCCCCCHHHH
DKIFNRFYRVDKARSREKGGNGLGLAIAKQLVEGYLGTINAVSEPDKGTTIKITLPYIDP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCC
KSK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA