Click here to switch to the map view.

The map label for this gene is cobD [H]

Identifier: 116872565

GI number: 116872565

Start: 1159534

End: 1160481

Strand: Direct

Name: cobD [H]

Synonym: lwe1149

Alternate gene names: 116872565

Gene position: 1159534-1160481 (Clockwise)

Preceding gene: 116872564

Following gene: 116872566

Centisome position: 41.2

GC content: 38.71

Gene sequence:

>948_bases
ATGACATTACTATTCTATACAGCATCATTTATTTTAGATTGTTTGTTAGGGGATCCTTATAGCTGGCCGCATCCAATTAA
AGCAATTGGCAATTGGATTCAATTATTAACTAATATTTTGCGAAAAAATTTTCACGGGAAATCATTATATTTTGCTGGAG
GAGTGTTATTTTTACTCACGGTTGGTTTGACGGGAGTTCTAACATGGTTCATTTTAATGATCAGCGCAAAAATCGCTTTC
TGGCTTTACGCAGCTTTTTTTGTCTACTTTAGTTATACAACACTCGCGATGACTTGCCTTGCGAAAGAGGCGTGGAAAAT
TCAGCGGACATTATCGAGCGGAGATTTGGTTGCGGCGAGAGTGCAGGTTGGGATGATTGTTGGTCGTGATACAGAGAAGC
TAACAGCAGAACAAATCAGTAAAGCAACAATAGAAACAGTGGCCGAAAATACAGCAGATGGCGTTATCGCACCATTATTT
TATTTGTTTATTGGTGGGCCAGTACTTGCTTTAATGTATAAGGCAGTCAATACACTGGATTCGATGGTCGGTTATAAAAA
TGAAAAGTACCGAGCCATTGGTTTTGTATCAGCAAAAATGGACGATATAGCCAATTTTATTCCTGCGAGATTATCTTGGT
TTTTCTTAGTAATTGCTAGTTTTATTTTAAGATATGATGGGCGTGCGTCTTGGGTGATAGGTCTTCGGGACCGGAAAAAC
CATACGAGTCCTAATTGTGCTTATCCGGAAGGTGCAGTAGCTGGAGCACTTGGTATAACACTAGGTGGAACACATGAATA
CTTCGGCGAAACAGTTGTTAAACCGACAATTGGAAGTGGAACTAAACCAGTCACGCAAAAAGAAATCAGCCAAACGATTC
ATTTGTTATACACAGCCTCCACTATTGCTTTTATCGTTTTTGCATGTATATATCTACTATTATTTTAA

Upstream 100 bases:

>100_bases
ATGGCGGCTATCAAAAGGGTCATACATTCGCGAGTTACTTGCATATTCATTTCTATCAAAACCCAGCCATTTTAACGCAT
ATGTTTGGAGCTTGTAGAAA

Downstream 100 bases:

>100_bases
AGGAGTGGCACAATGAATTATATTAAAAATCCAGCTAAAATTGAAGAGAAAAGTTTTGAAATCATTCAACAAATTATTGA
TGATATTCGCCCAGATTACA

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTLLFYTASFILDCLLGDPYSWPHPIKAIGNWIQLLTNILRKNFHGKSLYFAGGVLFLLTVGLTGVLTWFILMISAKIAF
WLYAAFFVYFSYTTLAMTCLAKEAWKIQRTLSSGDLVAARVQVGMIVGRDTEKLTAEQISKATIETVAENTADGVIAPLF
YLFIGGPVLALMYKAVNTLDSMVGYKNEKYRAIGFVSAKMDDIANFIPARLSWFFLVIASFILRYDGRASWVIGLRDRKN
HTSPNCAYPEGAVAGALGITLGGTHEYFGETVVKPTIGSGTKPVTQKEISQTIHLLYTASTIAFIVFACIYLLLF

Sequences:

>Translated_315_residues
MTLLFYTASFILDCLLGDPYSWPHPIKAIGNWIQLLTNILRKNFHGKSLYFAGGVLFLLTVGLTGVLTWFILMISAKIAF
WLYAAFFVYFSYTTLAMTCLAKEAWKIQRTLSSGDLVAARVQVGMIVGRDTEKLTAEQISKATIETVAENTADGVIAPLF
YLFIGGPVLALMYKAVNTLDSMVGYKNEKYRAIGFVSAKMDDIANFIPARLSWFFLVIASFILRYDGRASWVIGLRDRKN
HTSPNCAYPEGAVAGALGITLGGTHEYFGETVVKPTIGSGTKPVTQKEISQTIHLLYTASTIAFIVFACIYLLLF
>Mature_314_residues
TLLFYTASFILDCLLGDPYSWPHPIKAIGNWIQLLTNILRKNFHGKSLYFAGGVLFLLTVGLTGVLTWFILMISAKIAFW
LYAAFFVYFSYTTLAMTCLAKEAWKIQRTLSSGDLVAARVQVGMIVGRDTEKLTAEQISKATIETVAENTADGVIAPLFY
LFIGGPVLALMYKAVNTLDSMVGYKNEKYRAIGFVSAKMDDIANFIPARLSWFFLVIASFILRYDGRASWVIGLRDRKNH
TSPNCAYPEGAVAGALGITLGGTHEYFGETVVKPTIGSGTKPVTQKEISQTIHLLYTASTIAFIVFACIYLLLF

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 34832; Mature: 34701

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLFYTASFILDCLLGDPYSWPHPIKAIGNWIQLLTNILRKNFHGKSLYFAGGVLFLLT
CEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
VGLTGVLTWFILMISAKIAFWLYAAFFVYFSYTTLAMTCLAKEAWKIQRTLSSGDLVAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VQVGMIVGRDTEKLTAEQISKATIETVAENTADGVIAPLFYLFIGGPVLALMYKAVNTLD
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVGYKNEKYRAIGFVSAKMDDIANFIPARLSWFFLVIASFILRYDGRASWVIGLRDRKN
HHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
HTSPNCAYPEGAVAGALGITLGGTHEYFGETVVKPTIGSGTKPVTQKEISQTIHLLYTAS
CCCCCCCCCCCCHHHHHHEEECCCHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TIAFIVFACIYLLLF
HHHHHHHHHHHHHHC
>Mature Secondary Structure 
TLLFYTASFILDCLLGDPYSWPHPIKAIGNWIQLLTNILRKNFHGKSLYFAGGVLFLLT
EEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
VGLTGVLTWFILMISAKIAFWLYAAFFVYFSYTTLAMTCLAKEAWKIQRTLSSGDLVAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VQVGMIVGRDTEKLTAEQISKATIETVAENTADGVIAPLFYLFIGGPVLALMYKAVNTLD
HHHHHEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMVGYKNEKYRAIGFVSAKMDDIANFIPARLSWFFLVIASFILRYDGRASWVIGLRDRKN
HHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
HTSPNCAYPEGAVAGALGITLGGTHEYFGETVVKPTIGSGTKPVTQKEISQTIHLLYTAS
CCCCCCCCCCCCHHHHHHEEECCCHHHHCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TIAFIVFACIYLLLF
HHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA