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The map label for this gene is vanSB [H]

Identifier: 116872457

GI number: 116872457

Start: 1052741

End: 1054168

Strand: Direct

Name: vanSB [H]

Synonym: lwe1039

Alternate gene names: 116872457

Gene position: 1052741-1054168 (Clockwise)

Preceding gene: 116872456

Following gene: 116872458

Centisome position: 37.41

GC content: 30.74

Gene sequence:

>1428_bases
ATGAATAAAGTTAAAAACAAAATTAGTTGGAAAATTTTCTTGGTGTTTGTAAGCATTATTTTGATTTTTACTACATTGGT
TTATGCAATGCTGATTTTATTCTTGCCGCAATTTTATTATAATTATAAAACAAACCAAATTAATGATTATGCCGATGAGG
CCGTAAAAGCAGGAGAAAATGGCGATTTAAGTAATGTAGAAAAAGCGTTAGATGAATTTATGGATAATACAAATATACTG
CCGATTTTGACAGATAGTAGTGGTAGAATTATTTATATTCCTAATGTGAATATGAGTTCTCTCAATACTGCAATGCCAAC
GAGTGTTCAGGGTTCTGAATCAGAAAGTGGTTCAACAGCAACTCAATATCCAGAACAGTCAAAAACAAAAAATAAATCTA
TCTTGGTAGACGGGCAAGTATACGATCTCTCTTATACAATCAATGTCCAAAAAATAAATGATATAGCGAATGTTCTTTTA
CAATTTGCGCCATATTTTGTTTTATTTGCATTTATTTTAAGTTTATTAACTGCCTATTTTTTCTCAAGAAGAATGGTAAG
ACCGCTTTTACGTATGAATAAAGTAGCAGCGAAAATGGCGAAATTAAATTTCACTGAAGTATTACCAATTATGTCTCAAG
ATGAAATTGGACAACTTTCAGGAAATTTAAATGAGATGGCAATTAATTTAGAACAAACAATGCTGGAATTAAATGAAGTC
AATGAAAAATTACAAAAAGAAATTGAAAAAGAACGCCAACTAGAAGAAATGCGAAAAAATTTTGTTACTGCAATTTCTCA
TGAACTTAAATCACCACTTGCTGCTGTGATGGGGCAAGTCGAAGCAATGCGTTATAATGTTGCGCCATACGATAACCATC
CTAAATATTTACAAGAGTCTTATCAAATTTTAGAACAAATGTCTAAAATGATTCAAGAAATGTTAGATGTATCTAAAGTA
GAACAAACCAATCATATGGGACAACAAACTATGTTTTCTTTGACGGAAATGGTAGAAACTATTATTAATAACAAAAAAAC
AGCTCCAAGTCGTATAGACAAAAAAATCATCTTTGAATCTAAGGAAGAAGTTAAGCTCACTGCAAATTATGCCTTTACAG
AAAAAGTAATTGAAAACATTATCGAAAATGCTTTTGATTATTCTATAGGAGATTATGAGATTATAATCGACCTTCATAAT
AGAGGAGAAGGATTTTATTTTTCAGTGCATAATAAATCCGCTCGTATACCAGAGGAAGAGCTAGGTAAACTATTCGAACC
TTTTTATCGACTAGAAAAATCAGGCAATAAAAAAACAGGTGGTACTGGTTTAGGATTATTTATCATCGCTAAGTTTCTAA
ATATCCAGGCAATCCAGTATAAATTAATAAATGAGAATGATGGTGTCACTTTTCAAATGTGGCGATAA

Upstream 100 bases:

>100_bases
ATTGTTGATACATCTATTATTAACACCCATATGAAAAATTTACGTAAAAAATTGCATACTGAAAAAATTCGAACGATTAG
AGGTGCTGGCTATAAAATGG

Downstream 100 bases:

>100_bases
AAAATACAGCTAAAAAACAGATAGAGTTCATATGAACTCTATCTGTTTTTTGTATGCTTACTATATTAAGAAACGGAGGT
TAGAAAATGGATTTTATCAG

Product: sensor histidine kinase family protein

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MNKVKNKISWKIFLVFVSIILIFTTLVYAMLILFLPQFYYNYKTNQINDYADEAVKAGENGDLSNVEKALDEFMDNTNIL
PILTDSSGRIIYIPNVNMSSLNTAMPTSVQGSESESGSTATQYPEQSKTKNKSILVDGQVYDLSYTINVQKINDIANVLL
QFAPYFVLFAFILSLLTAYFFSRRMVRPLLRMNKVAAKMAKLNFTEVLPIMSQDEIGQLSGNLNEMAINLEQTMLELNEV
NEKLQKEIEKERQLEEMRKNFVTAISHELKSPLAAVMGQVEAMRYNVAPYDNHPKYLQESYQILEQMSKMIQEMLDVSKV
EQTNHMGQQTMFSLTEMVETIINNKKTAPSRIDKKIIFESKEEVKLTANYAFTEKVIENIIENAFDYSIGDYEIIIDLHN
RGEGFYFSVHNKSARIPEEELGKLFEPFYRLEKSGNKKTGGTGLGLFIIAKFLNIQAIQYKLINENDGVTFQMWR

Sequences:

>Translated_475_residues
MNKVKNKISWKIFLVFVSIILIFTTLVYAMLILFLPQFYYNYKTNQINDYADEAVKAGENGDLSNVEKALDEFMDNTNIL
PILTDSSGRIIYIPNVNMSSLNTAMPTSVQGSESESGSTATQYPEQSKTKNKSILVDGQVYDLSYTINVQKINDIANVLL
QFAPYFVLFAFILSLLTAYFFSRRMVRPLLRMNKVAAKMAKLNFTEVLPIMSQDEIGQLSGNLNEMAINLEQTMLELNEV
NEKLQKEIEKERQLEEMRKNFVTAISHELKSPLAAVMGQVEAMRYNVAPYDNHPKYLQESYQILEQMSKMIQEMLDVSKV
EQTNHMGQQTMFSLTEMVETIINNKKTAPSRIDKKIIFESKEEVKLTANYAFTEKVIENIIENAFDYSIGDYEIIIDLHN
RGEGFYFSVHNKSARIPEEELGKLFEPFYRLEKSGNKKTGGTGLGLFIIAKFLNIQAIQYKLINENDGVTFQMWR
>Mature_475_residues
MNKVKNKISWKIFLVFVSIILIFTTLVYAMLILFLPQFYYNYKTNQINDYADEAVKAGENGDLSNVEKALDEFMDNTNIL
PILTDSSGRIIYIPNVNMSSLNTAMPTSVQGSESESGSTATQYPEQSKTKNKSILVDGQVYDLSYTINVQKINDIANVLL
QFAPYFVLFAFILSLLTAYFFSRRMVRPLLRMNKVAAKMAKLNFTEVLPIMSQDEIGQLSGNLNEMAINLEQTMLELNEV
NEKLQKEIEKERQLEEMRKNFVTAISHELKSPLAAVMGQVEAMRYNVAPYDNHPKYLQESYQILEQMSKMIQEMLDVSKV
EQTNHMGQQTMFSLTEMVETIINNKKTAPSRIDKKIIFESKEEVKLTANYAFTEKVIENIIENAFDYSIGDYEIIIDLHN
RGEGFYFSVHNKSARIPEEELGKLFEPFYRLEKSGNKKTGGTGLGLFIIAKFLNIQAIQYKLINENDGVTFQMWR

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=373, Percent_Identity=22.7882037533512, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=26.8867924528302, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=283, Percent_Identity=24.0282685512367, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=27.5555555555556, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=315, Percent_Identity=22.8571428571429, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082128, Length=322, Percent_Identity=24.223602484472, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786783, Length=416, Percent_Identity=21.3942307692308, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790861, Length=342, Percent_Identity=23.0994152046784, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=335, Percent_Identity=22.3880597014925, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790346, Length=200, Percent_Identity=24.5, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=392, Percent_Identity=22.7040816326531, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54512; Mature: 54512

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVKNKISWKIFLVFVSIILIFTTLVYAMLILFLPQFYYNYKTNQINDYADEAVKAGEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
GDLSNVEKALDEFMDNTNILPILTDSSGRIIYIPNVNMSSLNTAMPTSVQGSESESGSTA
CCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCH
TQYPEQSKTKNKSILVDGQVYDLSYTINVQKINDIANVLLQFAPYFVLFAFILSLLTAYF
HCCCCHHCCCCCEEEECCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSRRMVRPLLRMNKVAAKMAKLNFTEVLPIMSQDEIGQLSGNLNEMAINLEQTMLELNEV
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
NEKLQKEIEKERQLEEMRKNFVTAISHELKSPLAAVMGQVEAMRYNVAPYDNHPKYLQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHH
YQILEQMSKMIQEMLDVSKVEQTNHMGQQTMFSLTEMVETIINNKKTAPSRIDKKIIFES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
KEEVKLTANYAFTEKVIENIIENAFDYSIGDYEIIIDLHNRGEGFYFSVHNKSARIPEEE
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHH
LGKLFEPFYRLEKSGNKKTGGTGLGLFIIAKFLNIQAIQYKLINENDGVTFQMWR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECC
>Mature Secondary Structure
MNKVKNKISWKIFLVFVSIILIFTTLVYAMLILFLPQFYYNYKTNQINDYADEAVKAGEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCC
GDLSNVEKALDEFMDNTNILPILTDSSGRIIYIPNVNMSSLNTAMPTSVQGSESESGSTA
CCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCH
TQYPEQSKTKNKSILVDGQVYDLSYTINVQKINDIANVLLQFAPYFVLFAFILSLLTAYF
HCCCCHHCCCCCEEEECCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSRRMVRPLLRMNKVAAKMAKLNFTEVLPIMSQDEIGQLSGNLNEMAINLEQTMLELNEV
HHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
NEKLQKEIEKERQLEEMRKNFVTAISHELKSPLAAVMGQVEAMRYNVAPYDNHPKYLQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHH
YQILEQMSKMIQEMLDVSKVEQTNHMGQQTMFSLTEMVETIINNKKTAPSRIDKKIIFES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
KEEVKLTANYAFTEKVIENIIENAFDYSIGDYEIIIDLHNRGEGFYFSVHNKSARIPEEE
CCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHH
LGKLFEPFYRLEKSGNKKTGGTGLGLFIIAKFLNIQAIQYKLINENDGVTFQMWR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]