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The map label for this gene is vanRB [H]

Identifier: 116872456

GI number: 116872456

Start: 1052086

End: 1052748

Strand: Direct

Name: vanRB [H]

Synonym: lwe1038

Alternate gene names: 116872456

Gene position: 1052086-1052748 (Clockwise)

Preceding gene: 116872455

Following gene: 116872457

Centisome position: 37.39

GC content: 32.13

Gene sequence:

>663_bases
ATGGAAAAAATACTTATAGCAGAAGATGATGTAACTATTTTAGGTGTAATTACCGCATTTTTAACCGAAGCAGGATATCA
AGTAACTACTGCGCAAAACGGAATAGAAGCTTATCACTTTTTTCAAAAAGAAGCATTTGATTTAATCATTATGGATATCA
TGATGCCAAGTATGGACGGGTATACATTAACGGAATTAATTCGTTCTACTTCATCAGCACCGATACTAATGATGACCGCA
TTATCCGAAGAAAGTGATGAGTTAAAAGGTTTTGATCTTGGAGCAGATGACTATATACAAAAACCATTCTCATATCTAGT
ATTACTAAAACGAGTACAAGTACTTTTAAGACGATCCAATCAAAAAGAAGTAGACAAGAAAAAATTGCGTTGTGGTAATA
TATCGGTTAATACAGAAACTTTTGAAGTAGTATCAGCAGGAGAAACAATTGAATTAACCAAAAAAGAATTTGATATATTG
GTCCTGCTAATACGAAATCAAAAGAAAGTTATTACGCGCGAAATGATTTTATCTCAAGTGTGGGACTTTGCAGCTATTGT
TGATACATCTATTATTAACACCCATATGAAAAATTTACGTAAAAAATTGCATACTGAAAAAATTCGAACGATTAGAGGTG
CTGGCTATAAAATGGATGAATAA

Upstream 100 bases:

>100_bases
TTTTGTTTCATTCGCATGATTCTTTTTTTGTAGAAAATGAAAAACTTCATGCAAACTCCATCTTTATTCTATATAATTAA
AGAACCATTAGGAGGCAGAT

Downstream 100 bases:

>100_bases
AGTTAAAAACAAAATTAGTTGGAAAATTTTCTTGGTGTTTGTAAGCATTATTTTGATTTTTACTACATTGGTTTATGCAA
TGCTGATTTTATTCTTGCCG

Product: CheY family two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MEKILIAEDDVTILGVITAFLTEAGYQVTTAQNGIEAYHFFQKEAFDLIIMDIMMPSMDGYTLTELIRSTSSAPILMMTA
LSEESDELKGFDLGADDYIQKPFSYLVLLKRVQVLLRRSNQKEVDKKKLRCGNISVNTETFEVVSAGETIELTKKEFDIL
VLLIRNQKKVITREMILSQVWDFAAIVDTSIINTHMKNLRKKLHTEKIRTIRGAGYKMDE

Sequences:

>Translated_220_residues
MEKILIAEDDVTILGVITAFLTEAGYQVTTAQNGIEAYHFFQKEAFDLIIMDIMMPSMDGYTLTELIRSTSSAPILMMTA
LSEESDELKGFDLGADDYIQKPFSYLVLLKRVQVLLRRSNQKEVDKKKLRCGNISVNTETFEVVSAGETIELTKKEFDIL
VLLIRNQKKVITREMILSQVWDFAAIVDTSIINTHMKNLRKKLHTEKIRTIRGAGYKMDE
>Mature_220_residues
MEKILIAEDDVTILGVITAFLTEAGYQVTTAQNGIEAYHFFQKEAFDLIIMDIMMPSMDGYTLTELIRSTSSAPILMMTA
LSEESDELKGFDLGADDYIQKPFSYLVLLKRVQVLLRRSNQKEVDKKKLRCGNISVNTETFEVVSAGETIELTKKEFDIL
VLLIRNQKKVITREMILSQVWDFAAIVDTSIINTHMKNLRKKLHTEKIRTIRGAGYKMDE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=38.7387387387387, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=34.9775784753363, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=32.4200913242009, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=34.4036697247706, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=29.7297297297297, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=31.2775330396476, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=35.2678571428571, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=30.4932735426009, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=31.7180616740088, Blast_Score=114, Evalue=3e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=32.7510917030568, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=31.0502283105023, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=221, Percent_Identity=28.5067873303167, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=25.8771929824561, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.1385281385281, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=131, Percent_Identity=30.5343511450382, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=33.9805825242718, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=106, Percent_Identity=36.7924528301887, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=149, Percent_Identity=26.8456375838926, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=29.1666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=30.3921568627451, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25094; Mature: 25094

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKILIAEDDVTILGVITAFLTEAGYQVTTAQNGIEAYHFFQKEAFDLIIMDIMMPSMDG
CCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
YTLTELIRSTSSAPILMMTALSEESDELKGFDLGADDYIQKPFSYLVLLKRVQVLLRRSN
HHHHHHHHCCCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
QKEVDKKKLRCGNISVNTETFEVVSAGETIELTKKEFDILVLLIRNQKKVITREMILSQV
HHHHHHHHHHCCCEEECCHHEEEEECCCEEEEHHHCCEEEEEEECCCHHHHHHHHHHHHH
WDFAAIVDTSIINTHMKNLRKKLHTEKIRTIRGAGYKMDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEKILIAEDDVTILGVITAFLTEAGYQVTTAQNGIEAYHFFQKEAFDLIIMDIMMPSMDG
CCCEEEECCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
YTLTELIRSTSSAPILMMTALSEESDELKGFDLGADDYIQKPFSYLVLLKRVQVLLRRSN
HHHHHHHHCCCCCCEEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
QKEVDKKKLRCGNISVNTETFEVVSAGETIELTKKEFDILVLLIRNQKKVITREMILSQV
HHHHHHHHHHCCCEEECCHHEEEEECCCEEEEHHHCCEEEEEEECCCHHHHHHHHHHHHH
WDFAAIVDTSIINTHMKNLRKKLHTEKIRTIRGAGYKMDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]