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The map label for this gene is yiaY [H]

Identifier: 116871985

GI number: 116871985

Start: 604737

End: 605888

Strand: Direct

Name: yiaY [H]

Synonym: lwe0565

Alternate gene names: 116871985

Gene position: 604737-605888 (Clockwise)

Preceding gene: 116871983

Following gene: 116871989

Centisome position: 21.49

GC content: 37.5

Gene sequence:

>1152_bases
ATGACAACACAAGTATTTTATGTGCCAGCAGTTAATTTAATGGGTAGAGGTTGTATATCGGATATTGGTGAACATATTCA
AGAATTAGGATTTAAAAAAGCACTTTTAGTAACAGATAAGTTTTTAAGTAGTAGCCCAATCTTGGATAAAGTAATTGCGC
CATTAAAAAAAGCGGGAGTCGCATTTTCGATTTTTGATGATGTAAAACCAAATCCAACATGCGAAAACGTCAACCAAGGA
TTAGCATTTTTGAAAAAAGAGAATTGTGATTTTATTATTTCTGTTGGTGGTGGCTCGCCTCAAGATGCTGCTAGTGGAAT
TAGTATTTTAGCGACAAATGGTGGAGATATGCGTGATTATGAAGGCGTTCATCAATCTAAGAAAAAAGGATTGCCTGTAG
TTGCAATTAATACGACAGCTGGGACATCTGCTGAAATCACGATTAATTATGTCATTACAGATGAAGACCGTGGTGTAAAA
ATGGTTTGTGTTGATAAAAATAGTCTTGCACGAATTTCTGTCAATGATCCAGAATTAATGGTGGACAAACCGGCAGCATT
AACCGCAGCAACTGGTATGGATGCACTAACCCATGCTGTTGAAGCATTAGTAACACCAGGTGCATATCCTGTAACCGATG
CTACAGCAGTTGCAGCGGTTGAGCTAATCTTCAATTATTTACCTCGTGCCGTAAAAGATGGCCACGATATCGAAGCAAGA
GAACAAATGGTATACGCGATTTTCTTAGGAGGTATGGCTTTCAATAATGCGGGACTTGGTTTTGTACATGCGATGGCTCA
TCAACTTGGTGGAGTGTATGATTTGCCACATGGTGTATGTAATGCAATGCTTCTACCAATTGTAGAACGTGAAAATGCTA
AGCGAGTACCAGAAAAATTCCGCAAAATTGCAAAAGCGATTGGGTTGGATGTGACAAATAAATCCAATCAAGAATGTGCG
GATTATGCAATTAAAAAAATTCGGGAGTTATCCATTGAAGTAGGTATTCCTGAAAAGTTATCAGAACTGGGTGTAACAGA
AGTTGATTTAAATAAATTAGCAGATAACTCACTTAAAGATGCCTGTGCTCCAGGAAATCCATTTATGCCTACAAAAGAAG
AAACAATCGCAATGTTTAAAGAGATTTTATAA

Upstream 100 bases:

>100_bases
GACTTATGTTTGAATTGTCGTTATTATGAAGAAGTAGAAAACGTTTTCAAAGTAATGCTATGATTTGTGAAAATACGAGC
AAATAGGAGGAGAACAGAAA

Downstream 100 bases:

>100_bases
TCCAATAAAAAAGAAGCTATCTAAATCAAATTAGATAGCTTCTTTTTGTGTTATGCTTGTTTTTTACGAAGTACAATTAC
AGTACCACTAGCTAAAAGAA

Product: alcohol dehydrogenase class IV

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTTQVFYVPAVNLMGRGCISDIGEHIQELGFKKALLVTDKFLSSSPILDKVIAPLKKAGVAFSIFDDVKPNPTCENVNQG
LAFLKKENCDFIISVGGGSPQDAASGISILATNGGDMRDYEGVHQSKKKGLPVVAINTTAGTSAEITINYVITDEDRGVK
MVCVDKNSLARISVNDPELMVDKPAALTAATGMDALTHAVEALVTPGAYPVTDATAVAAVELIFNYLPRAVKDGHDIEAR
EQMVYAIFLGGMAFNNAGLGFVHAMAHQLGGVYDLPHGVCNAMLLPIVERENAKRVPEKFRKIAKAIGLDVTNKSNQECA
DYAIKKIRELSIEVGIPEKLSELGVTEVDLNKLADNSLKDACAPGNPFMPTKEETIAMFKEIL

Sequences:

>Translated_383_residues
MTTQVFYVPAVNLMGRGCISDIGEHIQELGFKKALLVTDKFLSSSPILDKVIAPLKKAGVAFSIFDDVKPNPTCENVNQG
LAFLKKENCDFIISVGGGSPQDAASGISILATNGGDMRDYEGVHQSKKKGLPVVAINTTAGTSAEITINYVITDEDRGVK
MVCVDKNSLARISVNDPELMVDKPAALTAATGMDALTHAVEALVTPGAYPVTDATAVAAVELIFNYLPRAVKDGHDIEAR
EQMVYAIFLGGMAFNNAGLGFVHAMAHQLGGVYDLPHGVCNAMLLPIVERENAKRVPEKFRKIAKAIGLDVTNKSNQECA
DYAIKKIRELSIEVGIPEKLSELGVTEVDLNKLADNSLKDACAPGNPFMPTKEETIAMFKEIL
>Mature_382_residues
TTQVFYVPAVNLMGRGCISDIGEHIQELGFKKALLVTDKFLSSSPILDKVIAPLKKAGVAFSIFDDVKPNPTCENVNQGL
AFLKKENCDFIISVGGGSPQDAASGISILATNGGDMRDYEGVHQSKKKGLPVVAINTTAGTSAEITINYVITDEDRGVKM
VCVDKNSLARISVNDPELMVDKPAALTAATGMDALTHAVEALVTPGAYPVTDATAVAAVELIFNYLPRAVKDGHDIEARE
QMVYAIFLGGMAFNNAGLGFVHAMAHQLGGVYDLPHGVCNAMLLPIVERENAKRVPEKFRKIAKAIGLDVTNKSNQECAD
YAIKKIRELSIEVGIPEKLSELGVTEVDLNKLADNSLKDACAPGNPFMPTKEETIAMFKEIL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=405, Percent_Identity=25.679012345679, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI48994951, Length=380, Percent_Identity=51.0526315789474, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1789163, Length=369, Percent_Identity=42.2764227642276, Blast_Score=304, Evalue=5e-84,
Organism=Escherichia coli, GI87082107, Length=376, Percent_Identity=36.436170212766, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787493, Length=387, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789386, Length=349, Percent_Identity=23.7822349570201, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=386, Percent_Identity=26.9430051813472, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=44.4444444444444, Blast_Score=331, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24657991, Length=409, Percent_Identity=23.4718826405868, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41051; Mature: 40920

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQVFYVPAVNLMGRGCISDIGEHIQELGFKKALLVTDKFLSSSPILDKVIAPLKKAGV
CCCEEEEECCHHHHCCHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCC
AFSIFDDVKPNPTCENVNQGLAFLKKENCDFIISVGGGSPQDAASGISILATNGGDMRDY
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCEEEEEECCCCCHHH
EGVHQSKKKGLPVVAINTTAGTSAEITINYVITDEDRGVKMVCVDKNSLARISVNDPELM
HHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCEE
VDKPAALTAATGMDALTHAVEALVTPGAYPVTDATAVAAVELIFNYLPRAVKDGHDIEAR
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
EQMVYAIFLGGMAFNNAGLGFVHAMAHQLGGVYDLPHGVCNAMLLPIVERENAKRVPEKF
HHEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
RKIAKAIGLDVTNKSNQECADYAIKKIRELSIEVGIPEKLSELGVTEVDLNKLADNSLKD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHCCCCEEHHHHHHCCHHHH
ACAPGNPFMPTKEETIAMFKEIL
HCCCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TTQVFYVPAVNLMGRGCISDIGEHIQELGFKKALLVTDKFLSSSPILDKVIAPLKKAGV
CCEEEEECCHHHHCCHHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHCCC
AFSIFDDVKPNPTCENVNQGLAFLKKENCDFIISVGGGSPQDAASGISILATNGGDMRDY
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHCCEEEEEECCCCCHHH
EGVHQSKKKGLPVVAINTTAGTSAEITINYVITDEDRGVKMVCVDKNSLARISVNDPELM
HHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCEE
VDKPAALTAATGMDALTHAVEALVTPGAYPVTDATAVAAVELIFNYLPRAVKDGHDIEAR
EECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
EQMVYAIFLGGMAFNNAGLGFVHAMAHQLGGVYDLPHGVCNAMLLPIVERENAKRVPEKF
HHEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHH
RKIAKAIGLDVTNKSNQECADYAIKKIRELSIEVGIPEKLSELGVTEVDLNKLADNSLKD
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEECCCCHHHHHCCCCEEHHHHHHCCHHHH
ACAPGNPFMPTKEETIAMFKEIL
HCCCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]