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The map label for this gene is aroD [H]

Identifier: 116871882

GI number: 116871882

Start: 496577

End: 497335

Strand: Direct

Name: aroD [H]

Synonym: lwe0462

Alternate gene names: 116871882

Gene position: 496577-497335 (Clockwise)

Preceding gene: 116871881

Following gene: 116871883

Centisome position: 17.65

GC content: 39.39

Gene sequence:

>759_bases
ATGAATAAAGTAGTTGTTAAGAATGTGACGTTTGGTGAAGGTGCGCCAAAAATTTGTGTACCAATGGTCGGTAAAACAGT
TGCCGCTCTTAAAGAAGAAGCAGAAATGCTAAAAACAATTGATTTGGACGTTGTAGAATGGCGCGTTGATTTTTATGAGG
ACGTAAAAGATTTAGCAAAAGTGGAAACTGCGCTAGACGAAATTCGCGTAGTTTTACCAGAAACACCCATTTTATTCACT
TTCCGCAGTGCAAAAGAAGGCGGCGAACTAGCTGTTAGTGACGAATTTTATTTTGAATTAAATGAAACACTAGCAAGAAC
TGGCAAAATTGATTTAGTTGATGTGGAACTTTTCAATGAAGAAGCGGATGTTCTTCGCTTGATTGAAACAGCCCACAAAC
ATGATGTAAAAGTAGTTATGTCTAACCATGATTTTGATAAAACTCCTGCGAAAGAAGAAATCGTTTCTCGTTTAACTCGC
ATGGAAGCTCTTGGCGCGGATTTGCCGAAAATCGCTGTTATGCCAAAATCTGCTACAGACGTTTTAACTTTACTCGATGC
AACGAATACCGTATCTGAAAAGGCGGACCAACCAATCATTACTATGTCGATGGCAGGAACAGGCGTAATTAGTCGTCTTG
CTGGCGAAGTATTTGGTTCCGCAATGACATTTGGAGCAGCGAAAAAAGCATCTGCCCCTGGTCAAATTGATGTCAATGAA
TTACGCCATGTGCTTGATTTATTGCATAAACAATTTTAA

Upstream 100 bases:

>100_bases
TGCCAGTAGATTACATTAAAGAAATCCTATTTTAAAAACTTGCAATATAATAAGGTTATCGCTAATCTTAAGACATCATA
TCGAATGAGGAGAATTATAC

Downstream 100 bases:

>100_bases
TTTAGTCTCTTTTGAAAACCTTAAATTTAGATTTATTCTCTAAGTTTAAGGTTTTTTTGTTATAATGAAGAATCAAGAAA
TTTAAAGGAGACGGAACTGA

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLKTIDLDVVEWRVDFYEDVKDLAKVETALDEIRVVLPETPILFT
FRSAKEGGELAVSDEFYFELNETLARTGKIDLVDVELFNEEADVLRLIETAHKHDVKVVMSNHDFDKTPAKEEIVSRLTR
MEALGADLPKIAVMPKSATDVLTLLDATNTVSEKADQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNE
LRHVLDLLHKQF

Sequences:

>Translated_252_residues
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLKTIDLDVVEWRVDFYEDVKDLAKVETALDEIRVVLPETPILFT
FRSAKEGGELAVSDEFYFELNETLARTGKIDLVDVELFNEEADVLRLIETAHKHDVKVVMSNHDFDKTPAKEEIVSRLTR
MEALGADLPKIAVMPKSATDVLTLLDATNTVSEKADQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNE
LRHVLDLLHKQF
>Mature_252_residues
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLKTIDLDVVEWRVDFYEDVKDLAKVETALDEIRVVLPETPILFT
FRSAKEGGELAVSDEFYFELNETLARTGKIDLVDVELFNEEADVLRLIETAHKHDVKVVMSNHDFDKTPAKEEIVSRLTR
MEALGADLPKIAVMPKSATDVLTLLDATNTVSEKADQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNE
LRHVLDLLHKQF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family [H]

Homologues:

Organism=Escherichia coli, GI1787984, Length=251, Percent_Identity=56.9721115537849, Blast_Score=289, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018508
- InterPro:   IPR013785
- InterPro:   IPR001381 [H]

Pfam domain/function: PF01487 DHquinase_I [H]

EC number: =4.2.1.10 [H]

Molecular weight: Translated: 27702; Mature: 27702

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLKTIDLDVVEWRVDFYEDVKDLAK
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VETALDEIRVVLPETPILFTFRSAKEGGELAVSDEFYFELNETLARTGKIDLVDVELFNE
HHHHHHHHEEECCCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCC
EADVLRLIETAHKHDVKVVMSNHDFDKTPAKEEIVSRLTRMEALGADLPKIAVMPKSATD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHH
VLTLLDATNTVSEKADQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNE
HHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LRHVLDLLHKQF
HHHHHHHHHHCC
>Mature Secondary Structure
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLKTIDLDVVEWRVDFYEDVKDLAK
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VETALDEIRVVLPETPILFTFRSAKEGGELAVSDEFYFELNETLARTGKIDLVDVELFNE
HHHHHHHHEEECCCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEEEECCC
EADVLRLIETAHKHDVKVVMSNHDFDKTPAKEEIVSRLTRMEALGADLPKIAVMPKSATD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHH
VLTLLDATNTVSEKADQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNE
HHHHHHCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
LRHVLDLLHKQF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]