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The map label for this gene is srlR [H]

Identifier: 116871700

GI number: 116871700

Start: 304780

End: 305520

Strand: Direct

Name: srlR [H]

Synonym: lwe0280

Alternate gene names: 116871700

Gene position: 304780-305520 (Clockwise)

Preceding gene: 116871699

Following gene: 116871701

Centisome position: 10.83

GC content: 32.93

Gene sequence:

>741_bases
ATGATTCCGTATAAAAGACAAGAAAAAATCATGGAATTTTTAGGGTCAGAAGAGGTTATAAAAATTGAAGATCTTCAAAA
AATCATTCCAAATACATCTATATCAACATTAAGAAGAGATTTAAAAGAACTGGAAAGGCTTGGAAAAGTGAATATGCTTA
CAGGAGGAGCCGTTAAAATTTCCTCTAGTACTAGCGAATTGCCAATTTCAACTAAAAGTGTCCTTCAAACAGAAGAAAAA
GAGATTATTGCCAGTTTAGCTGCTAAAGAAATCAATGAAGGCGACGTTATTTATTTGGATTCTGGTTCTACTTGTACAGC
TTTATTAAATAAAATTTTAAATAAAAAAATTAGTATTTTCACAACGAATACAAGTATATTTAACATTTCCACAGAAATTA
AGGCAGAAATAACTATTTTAGGTGGAAGGTACAGTCCTTTTATCTCATCTATTAATGGTCCTTTAACAGACAGCAACATT
AAACTTTTCAATTTCGAAAAAGCCTTTTTAGGTGCAAATGGAATTGATTTGGCAAGAGGTGTAAGCACACCAAACTTAGT
AGAAGCCAACAAGAAAAAAGAAATCTTACAAGCCTCACAAAAAGCATTCTTACTATGCGACAGCTCAAAAATCCACAAGT
CTTCCGCAGTTAAAGCCTTTGAACTAAATCAAGTCACATTAATTACGGATAAGTACGACGTGGACATTGCTGGGTTGACG
AGTTTGATTGTACCGGATTGA

Upstream 100 bases:

>100_bases
TTTTTGCTAGTTTGACTAAGTTTGAAAATAAATGATAAAATGTAAATGAATTTAAAATAGGATGACATTTATGAATGAGT
TAAATTATTTGGAGGTATTT

Downstream 100 bases:

>100_bases
GTTAGTTGATTATGGGAGGAGAAACGAAATGATGAAAAAAACAGTACACGGATGGGAAATAATATCTAGTTTAGATGTAC
GAGTATACCAAGATGAAGCT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIPYKRQEKIMEFLGSEEVIKIEDLQKIIPNTSISTLRRDLKELERLGKVNMLTGGAVKISSSTSELPISTKSVLQTEEK
EIIASLAAKEINEGDVIYLDSGSTCTALLNKILNKKISIFTTNTSIFNISTEIKAEITILGGRYSPFISSINGPLTDSNI
KLFNFEKAFLGANGIDLARGVSTPNLVEANKKKEILQASQKAFLLCDSSKIHKSSAVKAFELNQVTLITDKYDVDIAGLT
SLIVPD

Sequences:

>Translated_246_residues
MIPYKRQEKIMEFLGSEEVIKIEDLQKIIPNTSISTLRRDLKELERLGKVNMLTGGAVKISSSTSELPISTKSVLQTEEK
EIIASLAAKEINEGDVIYLDSGSTCTALLNKILNKKISIFTTNTSIFNISTEIKAEITILGGRYSPFISSINGPLTDSNI
KLFNFEKAFLGANGIDLARGVSTPNLVEANKKKEILQASQKAFLLCDSSKIHKSSAVKAFELNQVTLITDKYDVDIAGLT
SLIVPD
>Mature_246_residues
MIPYKRQEKIMEFLGSEEVIKIEDLQKIIPNTSISTLRRDLKELERLGKVNMLTGGAVKISSSTSELPISTKSVLQTEEK
EIIASLAAKEINEGDVIYLDSGSTCTALLNKILNKKISIFTTNTSIFNISTEIKAEITILGGRYSPFISSINGPLTDSNI
KLFNFEKAFLGANGIDLARGVSTPNLVEANKKKEILQASQKAFLLCDSSKIHKSSAVKAFELNQVTLITDKYDVDIAGLT
SLIVPD

Specific function: Unknown

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=236, Percent_Identity=36.0169491525424, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI226510968, Length=233, Percent_Identity=28.3261802575107, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789519, Length=229, Percent_Identity=28.82096069869, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787540, Length=231, Percent_Identity=29.4372294372294, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790753, Length=185, Percent_Identity=29.7297297297297, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1789829, Length=218, Percent_Identity=29.3577981651376, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082344, Length=229, Percent_Identity=26.6375545851528, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789170, Length=238, Percent_Identity=28.1512605042017, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788069, Length=235, Percent_Identity=25.1063829787234, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790635, Length=236, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 26943; Mature: 26943

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPYKRQEKIMEFLGSEEVIKIEDLQKIIPNTSISTLRRDLKELERLGKVNMLTGGAVKI
CCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEE
SSSTSELPISTKSVLQTEEKEIIASLAAKEINEGDVIYLDSGSTCTALLNKILNKKISIF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCEEEEE
TTNTSIFNISTEIKAEITILGGRYSPFISSINGPLTDSNIKLFNFEKAFLGANGIDLARG
EECCEEEEEEEEEEEEEEEECCCCCHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCHHHHC
VSTPNLVEANKKKEILQASQKAFLLCDSSKIHKSSAVKAFELNQVTLITDKYDVDIAGLT
CCCCCHHCCCHHHHHHHHCCCEEEEECCCCCCHHHCEEEEECCEEEEEECCCCCCHHHHE
SLIVPD
EECCCC
>Mature Secondary Structure
MIPYKRQEKIMEFLGSEEVIKIEDLQKIIPNTSISTLRRDLKELERLGKVNMLTGGAVKI
CCCCHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCEEEE
SSSTSELPISTKSVLQTEEKEIIASLAAKEINEGDVIYLDSGSTCTALLNKILNKKISIF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCEEEEE
TTNTSIFNISTEIKAEITILGGRYSPFISSINGPLTDSNIKLFNFEKAFLGANGIDLARG
EECCEEEEEEEEEEEEEEEECCCCCHHHHHCCCCCCCCCEEEEEEHHHHHCCCCCHHHHC
VSTPNLVEANKKKEILQASQKAFLLCDSSKIHKSSAVKAFELNQVTLITDKYDVDIAGLT
CCCCCHHCCCHHHHHHHHCCCEEEEECCCCCCHHHCEEEEECCEEEEEECCCCCCHHHHE
SLIVPD
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3062173; 9278503; 9205837 [H]