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The map label for this gene is malL [H]

Identifier: 116871645

GI number: 116871645

Start: 233180

End: 234877

Strand: Direct

Name: malL [H]

Synonym: lwe0225

Alternate gene names: 116871645

Gene position: 233180-234877 (Clockwise)

Preceding gene: 116871644

Following gene: 116871646

Centisome position: 8.29

GC content: 34.81

Gene sequence:

>1698_bases
ATGAAATTAACAGAAGCAAAAGAATGGTGGAAAGAATCGGTCGTTTATCAAATCTATCCACGTAGTTTTCAAGATTCCAA
TGGTGATGGCATTGGAGATATTAGAGGGATTATTGAACGGCTTCCTTATTTAGCAGATTTAGGAATAAATGTGGTTTGGC
TTTGTCCGGTCTATAAATCGCCTATGGATGATGGTGGCTATGATATTTCTGATTATTATCAGATTGATCCAATGTTCGGA
ACAATGGACGATATGGATGAATTAATTGAAAAAGCTGGCGAATTAGGAATAAAAATATTAATGGATTTGGTGGTTAACCA
TACGTCCGATGAACATGAATGGTTTCAAAAAGCATTGGCTAATCCAAAAAGTAAATACCGTGATTATTATATTTTTCGAG
AAGGTATAAATGGGAATCCACCTAATAATTGGCGTTCTTATTTTGGTGGCTCTGCATGGGAACCTGTGCCTAGTGAGAGT
AACATGTTTTATCTACATGCTTTTTCTAAAAAACAGCCTGATTTAAATTGGGAAAATATTGCGGTTCGTAATGAATGTAT
CCAAATGATTAATTGGTGGCTTGAAAAAGGTTTAGGTGGATTTAGAATTGATGCTATTTTAAATTTGAAGAAAAGAATTG
AATATGGTGTTTTCCCAGCGAACGGAGAAGATGGGTTAGTATTCATTGGTCATTGGATTTTAAATCAGCCTGGGATTGAG
GAGTGGCTAAATGAAATTGATGAGCTTACATTTAAAAAACACAATGCGTTTACTGTGGCTGAAGCAGATGTACCAGAAGA
AAGACTCTCTGAATATATAGGCGAAAATGGTCATTTTCGTATGGTCTTTGATTTTAGTTATACAGATATTGATACGCCTG
AAACCGGAGAATGGTTTAAGCAGTCGAAATGGACTGTAAAAGAATTGAAAGACAAAATAATGATTAATGAATTGATAACA
CAGCGAAATGGTTGGGGTGCCAAGTATTTAGAGAACCATGATCAACCACGTTCGATAAATAAGTATTTACCACAAGAATA
TCAAGATGACCGTAGTAAAAAAATGTTAGCCGTTTTATTTATGATGTTACACGGAACTCCTTTCATATACCAAGGTCAAG
AGATTGGTATGAGTAATATTCGAATGGATAGTATAACCGATTATAATGATATTGCCACACATGATCAATATCGTCGTGCT
CTTCTTTCTGGAATGAGTCCTGACGAGGCACTTGAATGGATGTACCGTCGTAGTAGAGATAATTCGAGAACGCCAATGCA
GTGGACTAATCAAAAGAATGCTGGCTTCTCAAATGCGGATGAGATTTGGTTGAAAACCAATCCTAATTATCATGAAATTA
ATGTTGAGCAGGAACAAATGGATGAAACATCTGTATTAAATTTTTACAAGAAATTAATCTATTTAAGAAGTGATTTTAGT
AAATATAAAGAAGTAACAATTTATGGTGAATTAGTACCAGTGGAATCAAGTGATACAGTTATTGCCTACAAACGGATAAT
AGATGACAAAGAGCTCTTAATAGTTGTGAATTTTTCGGATGCTGAAGATCAATTATTCACAGAAGGCTGTTATGAACAGA
TAATTGCCAATGTGGAGTTGCCAAAAATTGTGGAAAATAAATTTATTTTACCCGCTTATACAGGCGCCGTTTTTTCAAAA
ATTTTGGAGGTAGAGTGA

Upstream 100 bases:

>100_bases
TGATTGCAGTGCCAATTACAATACTGTTTATTTATTTACAAAAATATTATGTTGAAGGCATTACCAGTGGTGCTGTTAAA
GGATAGGAGATAAATCAATA

Downstream 100 bases:

>100_bases
TTGCAAATTAAAAATAAAGCGATGTTAATTACTTATTCTGATAGTCTGGGTCGAAATATGGAAGAACTTTATCAAATGAT
GGAAACTTATTTTGAAGATG

Product: oligo-1,6-glucosidase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MKLTEAKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLADLGINVVWLCPVYKSPMDDGGYDISDYYQIDPMFG
TMDDMDELIEKAGELGIKILMDLVVNHTSDEHEWFQKALANPKSKYRDYYIFREGINGNPPNNWRSYFGGSAWEPVPSES
NMFYLHAFSKKQPDLNWENIAVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGVFPANGEDGLVFIGHWILNQPGIE
EWLNEIDELTFKKHNAFTVAEADVPEERLSEYIGENGHFRMVFDFSYTDIDTPETGEWFKQSKWTVKELKDKIMINELIT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLAVLFMMLHGTPFIYQGQEIGMSNIRMDSITDYNDIATHDQYRRA
LLSGMSPDEALEWMYRRSRDNSRTPMQWTNQKNAGFSNADEIWLKTNPNYHEINVEQEQMDETSVLNFYKKLIYLRSDFS
KYKEVTIYGELVPVESSDTVIAYKRIIDDKELLIVVNFSDAEDQLFTEGCYEQIIANVELPKIVENKFILPAYTGAVFSK
ILEVE

Sequences:

>Translated_565_residues
MKLTEAKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLADLGINVVWLCPVYKSPMDDGGYDISDYYQIDPMFG
TMDDMDELIEKAGELGIKILMDLVVNHTSDEHEWFQKALANPKSKYRDYYIFREGINGNPPNNWRSYFGGSAWEPVPSES
NMFYLHAFSKKQPDLNWENIAVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGVFPANGEDGLVFIGHWILNQPGIE
EWLNEIDELTFKKHNAFTVAEADVPEERLSEYIGENGHFRMVFDFSYTDIDTPETGEWFKQSKWTVKELKDKIMINELIT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLAVLFMMLHGTPFIYQGQEIGMSNIRMDSITDYNDIATHDQYRRA
LLSGMSPDEALEWMYRRSRDNSRTPMQWTNQKNAGFSNADEIWLKTNPNYHEINVEQEQMDETSVLNFYKKLIYLRSDFS
KYKEVTIYGELVPVESSDTVIAYKRIIDDKELLIVVNFSDAEDQLFTEGCYEQIIANVELPKIVENKFILPAYTGAVFSK
ILEVE
>Mature_565_residues
MKLTEAKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLADLGINVVWLCPVYKSPMDDGGYDISDYYQIDPMFG
TMDDMDELIEKAGELGIKILMDLVVNHTSDEHEWFQKALANPKSKYRDYYIFREGINGNPPNNWRSYFGGSAWEPVPSES
NMFYLHAFSKKQPDLNWENIAVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGVFPANGEDGLVFIGHWILNQPGIE
EWLNEIDELTFKKHNAFTVAEADVPEERLSEYIGENGHFRMVFDFSYTDIDTPETGEWFKQSKWTVKELKDKIMINELIT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLAVLFMMLHGTPFIYQGQEIGMSNIRMDSITDYNDIATHDQYRRA
LLSGMSPDEALEWMYRRSRDNSRTPMQWTNQKNAGFSNADEIWLKTNPNYHEINVEQEQMDETSVLNFYKKLIYLRSDFS
KYKEVTIYGELVPVESSDTVIAYKRIIDDKELLIVVNFSDAEDQLFTEGCYEQIIANVELPKIVENKFILPAYTGAVFSK
ILEVE

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=542, Percent_Identity=29.520295202952, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI61744475, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744477, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744483, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744479, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI65506891, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744481, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790687, Length=529, Percent_Identity=39.8865784499055, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1786604, Length=132, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI32565753, Length=532, Percent_Identity=24.4360902255639, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25147709, Length=498, Percent_Identity=26.1044176706827, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321731, Length=545, Percent_Identity=37.0642201834862, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6319776, Length=545, Percent_Identity=37.0642201834862, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6321726, Length=550, Percent_Identity=37.4545454545455, Blast_Score=309, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6322245, Length=547, Percent_Identity=34.5521023765996, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6322241, Length=545, Percent_Identity=37.7981651376147, Blast_Score=302, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6322021, Length=545, Percent_Identity=37.7981651376147, Blast_Score=302, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6324416, Length=545, Percent_Identity=37.7981651376147, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24583745, Length=538, Percent_Identity=37.7323420074349, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24583749, Length=541, Percent_Identity=36.7837338262477, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24583747, Length=541, Percent_Identity=36.7837338262477, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24586593, Length=557, Percent_Identity=35.1885098743267, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24586599, Length=536, Percent_Identity=34.5149253731343, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24586587, Length=565, Percent_Identity=32.5663716814159, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI45549022, Length=599, Percent_Identity=32.7212020033389, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24586589, Length=561, Percent_Identity=32.0855614973262, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24586597, Length=538, Percent_Identity=33.0855018587361, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24586591, Length=506, Percent_Identity=33.596837944664, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI221330053, Length=207, Percent_Identity=48.792270531401, Blast_Score=216, Evalue=4e-56,
Organism=Drosophila melanogaster, GI281360393, Length=503, Percent_Identity=32.4055666003976, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 66015; Mature: 66015

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTEAKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLADLGINVVWLCPVYKS
CCCCHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCC
PMDDGGYDISDYYQIDPMFGTMDDMDELIEKAGELGIKILMDLVVNHTSDEHEWFQKALA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
NPKSKYRDYYIFREGINGNPPNNWRSYFGGSAWEPVPSESNMFYLHAFSKKQPDLNWENI
CCHHHHCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
AVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGVFPANGEDGLVFIGHWILNQPGIE
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCHH
EWLNEIDELTFKKHNAFTVAEADVPEERLSEYIGENGHFRMVFDFSYTDIDTPETGEWFK
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHH
QSKWTVKELKDKIMINELITQRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLAVLF
HCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
MMLHGTPFIYQGQEIGMSNIRMDSITDYNDIATHDQYRRALLSGMSPDEALEWMYRRSRD
HHHCCCCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NSRTPMQWTNQKNAGFSNADEIWLKTNPNYHEINVEQEQMDETSVLNFYKKLIYLRSDFS
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KYKEVTIYGELVPVESSDTVIAYKRIIDDKELLIVVNFSDAEDQLFTEGCYEQIIANVEL
HHCEEEEEEEEEECCCCCCEEEHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PKIVENKFILPAYTGAVFSKILEVE
CHHHHCCEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLTEAKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLADLGINVVWLCPVYKS
CCCCHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCC
PMDDGGYDISDYYQIDPMFGTMDDMDELIEKAGELGIKILMDLVVNHTSDEHEWFQKALA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
NPKSKYRDYYIFREGINGNPPNNWRSYFGGSAWEPVPSESNMFYLHAFSKKQPDLNWENI
CCHHHHCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
AVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGVFPANGEDGLVFIGHWILNQPGIE
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCCCCCHH
EWLNEIDELTFKKHNAFTVAEADVPEERLSEYIGENGHFRMVFDFSYTDIDTPETGEWFK
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHH
QSKWTVKELKDKIMINELITQRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLAVLF
HCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
MMLHGTPFIYQGQEIGMSNIRMDSITDYNDIATHDQYRRALLSGMSPDEALEWMYRRSRD
HHHCCCCEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NSRTPMQWTNQKNAGFSNADEIWLKTNPNYHEINVEQEQMDETSVLNFYKKLIYLRSDFS
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KYKEVTIYGELVPVESSDTVIAYKRIIDDKELLIVVNFSDAEDQLFTEGCYEQIIANVEL
HHCEEEEEEEEEECCCCCCEEEHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
PKIVENKFILPAYTGAVFSKILEVE
CHHHHCCEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2120057; 8370659; 9193006 [H]