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The map label for this gene is lutP [H]

Identifier: 116691165

GI number: 116691165

Start: 3466564

End: 3468204

Strand: Reverse

Name: lutP [H]

Synonym: Bcen2424_3147

Alternate gene names: 116691165

Gene position: 3468204-3466564 (Counterclockwise)

Preceding gene: 116691167

Following gene: 116691163

Centisome position: 99.55

GC content: 68.43

Gene sequence:

>1641_bases
ATGAATCCCACCGACGCCCTACCGCCCGGCATCGTCTTCGCGCAACCGTTGACGCCCGTCGCCAATTCGCTGCTCCTGTC
GTTCCTCGTCGCCGCGATTCCGATCGCGGTCGCGCTGATTGCGCTCGGCGTGCTGCGCCGCCCCGCGTGGCAGGCGTCGC
TCGCCGGGCTCGTCGCGGGCCTCGCGGTGGCGATCGGCGCGTGGGGGATGCCGGCCGGGCTCGCATTCAACGCGGTCGGC
GCCGGCATGGCGCTCGCGGTCGTGCCGGTGATGTGGATCGTCTTCAACGCGCTGCTGCTGTACAACATCGCGGTGAAGTC
GGGCCGCTTCGACCAGTTCCGGCAGTGGATGCTCGACAACCTGCCCGACGATCGCCGCCTCGTGCTGCTCGTCGTCGCGT
TCTCGTTCGGCTGTCTGCTCGAAGGGATTTCCGGATTCGGCACGCCGGTCGCGATCACGAGCGCGCTGCTGATCGCGCTC
GGCTTTCCCGCGCTCGAAGCGCTCACCTATACGCTGCTGTTCAACACGGCGCCGGTCGCGTTCGGCGCGCTCGGCGTGCC
GATCACCGTGCTCGGCGCGGTCACGTCGCTGCCGCCCGCGACGCTCGCGCAGATGGTCGGCCGCCAGTTGCCGTTCTTCG
CGCTGCTGCTGCCGTTCTACGTGGTCGGCGCGTATGGCGGGCTGCGCTCGATCGCGAAGCTGTGGCCCGCGCTGCTCGTG
TCGGGCGGCAGCTTCGCGCTCGCGCAGTTCGTCACGTCGAACTTCCTCGGCTACCAGCTCACCGACGTGCTGTCGTCGCT
CACGTCGCTGATCGTGACGATCGGTTTCCTGCAGCTGTGGAAGCCGCAGCCCGATCCGCAATACGCGCTCGCGCGCAGCG
TGCCGGCCGCCGCCGGCGCCGCGCGCGCGGGTTTCGGCGGCTGGCTGCCGTGGCTCGTCGTGTCGGTGGTCGTGATCGTG
TGGGTGCACGCGAACATCGCGGCGATCGGCGACGTGAAGATCAAGTGGCCGGGCCTGCACAACGCCGTATACGTGTCGCT
GTACCACAAGCCGTATGCGGCGATCTGGGATTTCCAGCCGCTCGGCACGGGCACCGCGATCCTCGTGTCGGCAATCATCA
CGGCCGCGCTGACGCGCACCGGCCCCGGCGCGTTCGTCGAATGCGTGGTGAAGACGTGGCGGCAGACGTGGATCGCGATC
GTCACGGTGATGATGATCGTCGGGCTCGCGTACCTGCTGAACTACTCGGGCATCAGCTATACGCTCGGCACCGGCGTCGC
GTCCACCGGTGCGCTGTTCCCGCTGGTGTCGGCATCGCTCGGCTGGATCGCCGTGTTCCTGTCCGGCAGCGACACGTCGG
GCAACGCGCTGTTCGGCAACCTGCAGGTCGTCGCCGCCCGGCAGCTCGGCCTCGATCCGGTGCTGATGGCCGCCACCAAC
TCGTCGGGCGGCGTGATGGGCAAGATGATCTCGCCGCAGAACATCGCGACGGGCGTGTCGACGACGGACCTGAAAGGGCA
GGAGGGTGTCGTGTTCGCACGCACCTTCTGGCACAGCGTGATCCTCACGCTGTTGCTCGGCGTGCTGGTGTTCCTGCAGC
AGCACGTGCTGACCTGGATGATTCCGGCGCTGCCGAAGTGA

Upstream 100 bases:

>100_bases
TGCGTACGCAAGCGCCTGATCGTGGCCGTGACTGCAGGACATCGCCTTGACCCGAACCCGGCGCATCGAGATGCGAACCC
GGGTCGACTCTGGAGACACG

Downstream 100 bases:

>100_bases
CGCGCGGCGCGGCGACAGAAGGAAGGCACGAGGGAAGCAACGAGGGAAGGCGCGGGAAAAGCGCCACGTAGTGTGCGGAA
GCGGTGAACGCGCGGCGGCT

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MNPTDALPPGIVFAQPLTPVANSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSIAKLWPALLV
SGGSFALAQFVTSNFLGYQLTDVLSSLTSLIVTIGFLQLWKPQPDPQYALARSVPAAAGAARAGFGGWLPWLVVSVVVIV
WVHANIAAIGDVKIKWPGLHNAVYVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGPGAFVECVVKTWRQTWIAI
VTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLDPVLMAATN
SSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK

Sequences:

>Translated_546_residues
MNPTDALPPGIVFAQPLTPVANSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSIAKLWPALLV
SGGSFALAQFVTSNFLGYQLTDVLSSLTSLIVTIGFLQLWKPQPDPQYALARSVPAAAGAARAGFGGWLPWLVVSVVVIV
WVHANIAAIGDVKIKWPGLHNAVYVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGPGAFVECVVKTWRQTWIAI
VTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLDPVLMAATN
SSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK
>Mature_546_residues
MNPTDALPPGIVFAQPLTPVANSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAGLAVAIGAWGMPAGLAFNAVG
AGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDNLPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIAL
GFPALEALTYTLLFNTAPVAFGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSIAKLWPALLV
SGGSFALAQFVTSNFLGYQLTDVLSSLTSLIVTIGFLQLWKPQPDPQYALARSVPAAAGAARAGFGGWLPWLVVSVVVIV
WVHANIAAIGDVKIKWPGLHNAVYVSLYHKPYAAIWDFQPLGTGTAILVSAIITAALTRTGPGAFVECVVKTWRQTWIAI
VTVMMIVGLAYLLNYSGISYTLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLDPVLMAATN
SSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWMIPALPK

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=548, Percent_Identity=39.4160583941606, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=39.5985401459854, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57289; Mature: 57289

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTDALPPGIVFAQPLTPVANSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTYTLLFNTAPVA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
FGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSIAKLWPALLV
HHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGSFALAQFVTSNFLGYQLTDVLSSLTSLIVTIGFLQLWKPQPDPQYALARSVPAAAGA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCC
ARAGFGGWLPWLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVYVSLYHKPYAAIWDFQP
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCEEEEEEECCCCHHHCCCCC
LGTGTAILVSAIITAALTRTGPGAFVECVVKTWRQTWIAIVTVMMIVGLAYLLNYSGISY
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLDPVLMAATN
ECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCCCCCEEEEEEC
SSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWM
CCCCCEEECCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPALPK
HCCCCC
>Mature Secondary Structure
MNPTDALPPGIVFAQPLTPVANSLLLSFLVAAIPIAVALIALGVLRRPAWQASLAGLVAG
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAVAIGAWGMPAGLAFNAVGAGMALAVVPVMWIVFNALLLYNIAVKSGRFDQFRQWMLDN
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
LPDDRRLVLLVVAFSFGCLLEGISGFGTPVAITSALLIALGFPALEALTYTLLFNTAPVA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHH
FGALGVPITVLGAVTSLPPATLAQMVGRQLPFFALLLPFYVVGAYGGLRSIAKLWPALLV
HHHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGSFALAQFVTSNFLGYQLTDVLSSLTSLIVTIGFLQLWKPQPDPQYALARSVPAAAGA
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHCC
ARAGFGGWLPWLVVSVVVIVWVHANIAAIGDVKIKWPGLHNAVYVSLYHKPYAAIWDFQP
CCCCCCCHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCEEEEEEECCCCHHHCCCCC
LGTGTAILVSAIITAALTRTGPGAFVECVVKTWRQTWIAIVTVMMIVGLAYLLNYSGISY
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TLGTGVASTGALFPLVSASLGWIAVFLSGSDTSGNALFGNLQVVAARQLGLDPVLMAATN
ECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCEEEECCEEEEHHHCCCCCEEEEEEC
SSGGVMGKMISPQNIATGVSTTDLKGQEGVVFARTFWHSVILTLLLGVLVFLQQHVLTWM
CCCCCEEECCCCCHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPALPK
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]