Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 116691150

GI number: 116691150

Start: 3449634

End: 3450647

Strand: Direct

Name: gyaR [H]

Synonym: Bcen2424_3132

Alternate gene names: 116691150

Gene position: 3449634-3450647 (Clockwise)

Preceding gene: 116691148

Following gene: 116691153

Centisome position: 99.02

GC content: 65.88

Gene sequence:

>1014_bases
ATGAAAATTGCCATCCTCGACGACTACCAGGACGCCGTCCGCAAGCTGAACTGCTTCGAGATGCTCGCCGGCCACGACGT
AAAGGTCTTCAACAATACGGTGCGCGGCCTCGGACAGCTCGCCAGCCGTCTGGCGGAAGTCGAGGCGCTCGTGCTGATTC
GTGAACGGACCCCGATTACGTCCCAGTTGCTCGCCAAGCTGCCGAACCTGCGCATGATCAGCCAGACCGGCCGCGTGTCG
AGCCATATCGATCTCGACGCGTGTACCGACCGCGGCGTCGCGGTGCTCGAAGGCACCGGTTCGCCGGTCGCGCCGGCCGA
GCTGACCTGGGCGCTCGTGATGGCCGCCCAGCGCCGCATTCCGCAGTACGTCGCGAACCTGAAGCAGGGTGCGTGGCAGC
AGTCGGGCCTGAAGACGTCGGCGCTGCCGCCGAACTTCGGCCTCGGCCAGGTGCTGCGCGGCCAGACGCTCGGCATCTGG
GGCTACGGCAAGATCGGCCGGCTCGTCGCCGGCTACGGCAAGGCGTTCGGGATGAACGTGTTGATCTGGGGCCGCGAGCA
TTCGCTCGAAGCCGCGCGCGCCGACGGCTACACGGCCGCCGAGAGCCGCGAAGCGCTGTTCGAGCAAAGCGACGTGCTGT
CGCTGCACCTGCGCCTGCACGACGACACGCGCGGCATCGTGAAGCAGGAAGACCTGATGCGGATGAAGCCGACGTCGCTG
CTCGTCAACACGAGCCGCGCCGAGCTGCTCGAGGAAAACGCGCTCGTCAACGCGCTGTCGCACAACCGGCCGGGCATGGT
CGCGATCGACGTGTTCGAAAGCGAGCCGATCCTGCAGGGCTACAGCCTGCTGCGGATGGAAAACGTGATCTGCACGCCGC
ACATCGGCTACGTCGAGCGCGAAAGCTACGAACTGTATTTCAGTGCCGCATTCCGCAACATTCTCGCGTTCGACGACGGC
GACATGTCGAGCGTCGCCAACCCGGAAGCGCTGACGCCGATCCGCAAGCGCTGA

Upstream 100 bases:

>100_bases
CAGCCGACGTAGCATCATGTCGGCCCCGGCCGGGCGGGACGGGTGCGCAAGGTGCGCCGCCGCCACGGCCCCGCTTTCAA
CGCGCGACACCCCGTTCACC

Downstream 100 bases:

>100_bases
TCGCACGGGCTGCGCGCGTCGCGCGGCCCCCTTTCATTCCCGCTCGTCAGGCGGCCACGCGGCCGCCCGTCATCGCGCCG
ACCCGCGTGAGGAAGTGCTC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPITSQLLAKLPNLRMISQTGRVS
SHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDDG
DMSSVANPEALTPIRKR

Sequences:

>Translated_337_residues
MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPITSQLLAKLPNLRMISQTGRVS
SHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDDG
DMSSVANPEALTPIRKR
>Mature_337_residues
MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPITSQLLAKLPNLRMISQTGRVS
SHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRIPQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVERESYELYFSAAFRNILAFDDG
DMSSVANPEALTPIRKR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=333, Percent_Identity=27.6276276276276, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=32.5490196078431, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=32.5490196078431, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=30.5882352941176, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=30.5882352941176, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=28.968253968254, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=32.824427480916, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI87082289, Length=290, Percent_Identity=30, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=290, Percent_Identity=30, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=264, Percent_Identity=25.7575757575758, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=328, Percent_Identity=28.0487804878049, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=286, Percent_Identity=27.972027972028, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=311, Percent_Identity=26.6881028938907, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=273, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=28.4444444444444, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=25.296442687747, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=31.9838056680162, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=32, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574286, Length=253, Percent_Identity=28.4584980237154, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=27.3648648648649, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=26.0536398467433, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=26.0536398467433, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=26.0536398467433, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=26.0536398467433, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=26.0536398467433, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=27.1698113207547, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24585516, Length=230, Percent_Identity=25.6521739130435, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37202; Mature: 37202

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIT
CEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHH
SQLLAKLPNLRMISQTGRVSSHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFRNILAFDDGDMSSVANPEALTPIRKR
CCEEEEEEHHHHHHHEECCCCCHHCCCCHHCCCCCCC
>Mature Secondary Structure
MKIAILDDYQDAVRKLNCFEMLAGHDVKVFNNTVRGLGQLASRLAEVEALVLIRERTPIT
CEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHH
SQLLAKLPNLRMISQTGRVSSHIDLDACTDRGVAVLEGTGSPVAPAELTWALVMAAQRRI
HHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSALPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LIWGREHSLEAARADGYTAAESREALFEQSDVLSLHLRLHDDTRGIVKQEDLMRMKPTSL
EEECCCCCCHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCE
LVNTSRAELLEENALVNALSHNRPGMVAIDVFESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFSAAFRNILAFDDGDMSSVANPEALTPIRKR
CCEEEEEEHHHHHHHEECCCCCHHCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]