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The map label for this gene is lon [H]

Identifier: 116691067

GI number: 116691067

Start: 3363821

End: 3364801

Strand: Reverse

Name: lon [H]

Synonym: Bcen2424_3049

Alternate gene names: 116691067

Gene position: 3364801-3363821 (Counterclockwise)

Preceding gene: 116691076

Following gene: 116691066

Centisome position: 96.58

GC content: 68.5

Gene sequence:

>981_bases
ATGACGACGGCGATGGTGAAGCAGGAACTGGCGGTGGCGTCCTTCAGCACGGTGTACGACCTCGAGCAGGTCGAGACGGC
GCTGGGCGACCTGAACGAGAGCGCAAGCGATGCGCTGCGCTCGACCTACGAGAAGATGCTCAAGACGGGGAATCTGCGCT
TCTGCGTGAAGCCGACCCGGATGCCGTCGTTCGACGCGCTCGGCGAAGCATTGCCGAATTTCGGCGAGCCGCTCGCCGAC
GTGCGCAAGCAGATCGCGCTGTGTCTCGAAACGGAGGACCGGCTCGAACTGATGCCGATCCTGCTGCTCGGGCCGCCCGG
GATCGGCAAGACGCATTTCGCGAAGGCGCTCGCGCAACTGCTCGGCACCGCGTACCACTACGTGCCGATGAGTTCGCTGA
CGGCCGGCTGGATCCTGTCCGGCGCGTCGTCGCAGTGGAAGAACGCGAAGCCCGGCAAGGTGTTCGACGCGCTCGTGAAC
GGCAGCTACGCGAACCCGGTGATCGCGGTCGACGAGATCGACAAGGCCGGCAGCGATGCGCAATACGATCCGCTCGGCGC
GCTGTATGCGTTGCTCGAGCACGACACCGCGCGCGCGTTCGTCGACGAATTCGCGGAAGTGCCGATCGACGCGGGCAACG
TGATCTGGATCGCGACCGCGAACGACGCGCACGCGATTCCGGAGCCGCTGCTCAACCGGATGAACGTGTACGAGATCGCG
GCGCCCGATGCGGCCGGCGCGCGCCGCATCGCGCAGACGATCTACAACGAGATCCGCACGTCACATGCGTGGGGGCGGCG
CTTCCCCGAGACGCTCGGCGACGATGCGCTCGACGTGCTGGCCGCGACGCCGCCGCGCACGATGCGCCGCGCGCTGCTGC
ACGCGTTCGGCGCCGCCCGGCTCGACGGCCGCGACGCGATCGGGCCGGCCGACATCCGCGCCGACGAAGGCGCGGCGAAG
CGCCGGCCGATCGGCTTCTGA

Upstream 100 bases:

>100_bases
CAGACCCGCCCGGCTGCTTGCTTGCACGGCGATACGGGATCGCTACACTGAAATCGTAAGGGTCTGATGAGTGTGTGACG
GCAAGTGGAGCGAGGTGGGT

Downstream 100 bases:

>100_bases
CGCGGCCACGCGCGCACGGCCGCGGCGGGCGCGCGTGGCGTTGGTCGCGTTGCGGCCGCCTCATTGTCCGCACCACCGGC
CGTATCGCCGCGACGCGATG

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTTAMVKQELAVASFSTVYDLEQVETALGDLNESASDALRSTYEKMLKTGNLRFCVKPTRMPSFDALGEALPNFGEPLAD
VRKQIALCLETEDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVN
GSYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIA
APDAAGARRIAQTIYNEIRTSHAWGRRFPETLGDDALDVLAATPPRTMRRALLHAFGAARLDGRDAIGPADIRADEGAAK
RRPIGF

Sequences:

>Translated_326_residues
MTTAMVKQELAVASFSTVYDLEQVETALGDLNESASDALRSTYEKMLKTGNLRFCVKPTRMPSFDALGEALPNFGEPLAD
VRKQIALCLETEDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVN
GSYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIA
APDAAGARRIAQTIYNEIRTSHAWGRRFPETLGDDALDVLAATPPRTMRRALLHAFGAARLDGRDAIGPADIRADEGAAK
RRPIGF
>Mature_325_residues
TTAMVKQELAVASFSTVYDLEQVETALGDLNESASDALRSTYEKMLKTGNLRFCVKPTRMPSFDALGEALPNFGEPLADV
RKQIALCLETEDRLELMPILLLGPPGIGKTHFAKALAQLLGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNG
SYANPVIAVDEIDKAGSDAQYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIAA
PDAAGARRIAQTIYNEIRTSHAWGRRFPETLGDDALDVLAATPPRTMRRALLHAFGAARLDGRDAIGPADIRADEGAAKR
RPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=142, Percent_Identity=35.2112676056338, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI31377667, Length=142, Percent_Identity=33.8028169014084, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1786643, Length=167, Percent_Identity=32.9341317365269, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17556486, Length=182, Percent_Identity=29.6703296703297, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17505831, Length=138, Percent_Identity=34.7826086956522, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319449, Length=154, Percent_Identity=35.0649350649351, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24666867, Length=138, Percent_Identity=36.9565217391304, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI221513036, Length=138, Percent_Identity=36.9565217391304, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35232; Mature: 35101

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVKQELAVASFSTVYDLEQVETALGDLNESASDALRSTYEKMLKTGNLRFCVKPTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
MPSFDALGEALPNFGEPLADVRKQIALCLETEDRLELMPILLLGPPGIGKTHFAKALAQL
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGSDA
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEEE
APDAAGARRIAQTIYNEIRTSHAWGRRFPETLGDDALDVLAATPPRTMRRALLHAFGAAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHC
LDGRDAIGPADIRADEGAAKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAMVKQELAVASFSTVYDLEQVETALGDLNESASDALRSTYEKMLKTGNLRFCVKPTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCC
MPSFDALGEALPNFGEPLADVRKQIALCLETEDRLELMPILLLGPPGIGKTHFAKALAQL
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWILSGASSQWKNAKPGKVFDALVNGSYANPVIAVDEIDKAGSDA
HHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTARAFVDEFAEVPIDAGNVIWIATANDAHAIPEPLLNRMNVYEIA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCEEEEE
APDAAGARRIAQTIYNEIRTSHAWGRRFPETLGDDALDVLAATPPRTMRRALLHAFGAAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHC
LDGRDAIGPADIRADEGAAKRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA