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The map label for this gene is gor [H]

Identifier: 116691024

GI number: 116691024

Start: 3318288

End: 3319643

Strand: Reverse

Name: gor [H]

Synonym: Bcen2424_3006

Alternate gene names: 116691024

Gene position: 3319643-3318288 (Counterclockwise)

Preceding gene: 116691025

Following gene: 116691023

Centisome position: 95.29

GC content: 68.58

Gene sequence:

>1356_bases
ATGGATTTCGACTACGACCTGTTCGTCATCGGCGCCGGCTCGGGCGGCGTGCGGCTCGCACGCATGTCCGCGTCATACGG
CGCACGCGTCGGCATAGCGGAAGAGGAGCAGATCGGTGGCACCTGCGTGCTGCGCGGCTGCATCCCGAAGAAGCTGCTCG
TCTACGCGTCGCACTACCCGCACGAAGTCGACGACGCGAAGGGCTTCGGCTGGACCTTTGGCGCCGGCACGCTCGACTGG
CCCGCGCTGATCGCCGCGAAGGATCGCGAGATCAACCGGCTGAGCGACATCTACATCAACCTGCTGCGGCAATCGGGCGT
CGACATGCACACCGGCCGCGCGACGCTCGTCGATGCGCATACCGTCGCGATCGGCGAGCGCACGATCCGCGCGCGCCACA
TCGCGATCGCGACCGGCTCGCGGCCGTCGCTGCCGCCGCGGCCCGGCATCGAGCATGCGATCACGTCGCGCGAGGCGCTG
TCGCTCGCGGCGCTGCCCAAACGCATCGCGGTGGTCGGCGGCGGCTATATCGCGGTCGAGTTCGCGGGCATCTTCAACGG
TTTCGGCAGCCACGTCGAGCTGTTCTATCGCGGCGAGCAAATCCTGCGCGGCTTCGACGACGACGTGCGTCAATTCCTGA
CCGACGAGATGACGAAGCAGGGCGTCACGATTCATGCGCGCGCGGTGATCGAATCGATCGAGCGCGCAGATGACGGCACG
CTGTTCGTGCAGGTCGGCGACGCGCGGCACGGGCCGTACGATCAGGTGCTCTATGCGACCGGCCGCGTGCCGAACGTCGA
CGGAATCGGGCTCGAGCAGGCGGGCATCCTGCTCGATGCGCGCGGCGCGATTGCCGTCGATGCATATTCGGCGACGTCGG
TGCCGTCGATCCACGCGATCGGTGACGTCACGTCGCGGCCGCAGCTCACGCCGGTCGCGACGCGCGACGCCGGGCTACTC
GCGCGCACGTTGTTCGGCGGGTCGCGTGTGGCGGTCGACCACGCGTACGTGCCGTCGGCCGTGTTCAGCCAGCCCGAGGT
CGCGACGGTCGGCCTGACCGAAGCCGATGCGCGTCGTACGCTGGGCGACGTCGACATCTACCGCACGTCGTTCAAGGCGC
TGCGTCACACGCTGTCGGGCCGCGACGAGCGCACGCTGATGAAGCTCGTCGTCGCGCGCGACAGCCAGCGCGTGGTCGGC
GCGCACATGGTCGGCCGCGACGCGGGCGAGATCATCCAGGGCATCGCGATCGCGATTCGCGCGGGCGCGACGAAGGCGCA
GTTCGACGACACGATCGGCATTCATCCGACCGCAGCCGAGGAATTCGTGACGATGCGGCAGAAGGTGGCCGATTAG

Upstream 100 bases:

>100_bases
TCTCGCCGTTTTTTATTGGGCGCGCGGCACGCACCACGCGCCGCACGAATTCCCGAATCTTGCTATCGTCCCTCCATCCG
AACTGCGATGAGGGAATGCG

Downstream 100 bases:

>100_bases
CAGGAACCGGGAAACCACGCGCGCGTTTGCACCGATGCACGCGCGCGCGCGGCCGGCATGCCGAACGGCGTATTTTCGAG
ATATCGATCGTTCGGATCGA

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVDDAKGFGWTFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVDMHTGRATLVDAHTVAIGERTIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVELFYRGEQILRGFDDDVRQFLTDEMTKQGVTIHARAVIESIERADDGT
LFVQVGDARHGPYDQVLYATGRVPNVDGIGLEQAGILLDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDAGLL
ARTLFGGSRVAVDHAYVPSAVFSQPEVATVGLTEADARRTLGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD

Sequences:

>Translated_451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVDDAKGFGWTFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVDMHTGRATLVDAHTVAIGERTIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVELFYRGEQILRGFDDDVRQFLTDEMTKQGVTIHARAVIESIERADDGT
LFVQVGDARHGPYDQVLYATGRVPNVDGIGLEQAGILLDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDAGLL
ARTLFGGSRVAVDHAYVPSAVFSQPEVATVGLTEADARRTLGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
>Mature_451_residues
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYPHEVDDAKGFGWTFGAGTLDW
PALIAAKDREINRLSDIYINLLRQSGVDMHTGRATLVDAHTVAIGERTIRARHIAIATGSRPSLPPRPGIEHAITSREAL
SLAALPKRIAVVGGGYIAVEFAGIFNGFGSHVELFYRGEQILRGFDDDVRQFLTDEMTKQGVTIHARAVIESIERADDGT
LFVQVGDARHGPYDQVLYATGRVPNVDGIGLEQAGILLDARGAIAVDAYSATSVPSIHAIGDVTSRPQLTPVATRDAGLL
ARTLFGGSRVAVDHAYVPSAVFSQPEVATVGLTEADARRTLGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVG
AHMVGRDAGEIIQGIAIAIRAGATKAQFDDTIGIHPTAAEEFVTMRQKVAD

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=37.6086956521739, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=37.1549893842887, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=34.8837209302326, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=34.8837209302326, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=34.8837209302326, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=34.8837209302326, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=34.453781512605, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=34.8837209302326, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=32.5581395348837, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=30.3493449781659, Blast_Score=190, Evalue=3e-48,
Organism=Escherichia coli, GI1789915, Length=428, Percent_Identity=40.1869158878505, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=29.6213808463252, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082354, Length=459, Percent_Identity=29.4117647058824, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=31.4855875831486, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=36.6071428571429, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=36.6071428571429, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=467, Percent_Identity=33.6188436830835, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71982272, Length=482, Percent_Identity=32.1576763485477, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=32.3144104803493, Blast_Score=204, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=36.8763557483731, Blast_Score=296, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=28.755364806867, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=464, Percent_Identity=26.7241379310345, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=37.1002132196162, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=37.1002132196162, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=37.1002132196162, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=34.6072186836518, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=31.4285714285714, Blast_Score=205, Evalue=4e-53,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48365; Mature: 48365

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCCCEEEECCCC
HEVDDAKGFGWTFGAGTLDWPALIAAKDREINRLSDIYINLLRQSGVDMHTGRATLVDAH
CCCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCEEEEEEE
TVAIGERTIRARHIAIATGSRPSLPPRPGIEHAITSREALSLAALPKRIAVVGGGYIAVE
EEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
FAGIFNGFGSHVELFYRGEQILRGFDDDVRQFLTDEMTKQGVTIHARAVIESIERADDGT
EEHHHCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCE
LFVQVGDARHGPYDQVLYATGRVPNVDGIGLEQAGILLDARGAIAVDAYSATSVPSIHAI
EEEEECCCCCCCCHHEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCEEEC
GDVTSRPQLTPVATRDAGLLARTLFGGSRVAVDHAYVPSAVFSQPEVATVGLTEADARRT
CCCCCCCCCCEECCCCCHHHHHHHCCCCEEEEECCCCCHHHCCCCCEEEEECCHHHHHHH
LGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGRDAGEIIQGIAIAIR
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHEEEE
AGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFDYDLFVIGAGSGGVRLARMSASYGARVGIAEEEQIGGTCVLRGCIPKKLLVYASHYP
CCCCEEEEEEECCCCCEEEEEECCCCCCEECCCCHHHCCCEEEEECCCCCCCEEEECCCC
HEVDDAKGFGWTFGAGTLDWPALIAAKDREINRLSDIYINLLRQSGVDMHTGRATLVDAH
CCCCCCCCCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCEEEEEEE
TVAIGERTIRARHIAIATGSRPSLPPRPGIEHAITSREALSLAALPKRIAVVGGGYIAVE
EEEECCCEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCEEEEE
FAGIFNGFGSHVELFYRGEQILRGFDDDVRQFLTDEMTKQGVTIHARAVIESIERADDGT
EEHHHCCCCCEEEEEECCHHHHCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCE
LFVQVGDARHGPYDQVLYATGRVPNVDGIGLEQAGILLDARGAIAVDAYSATSVPSIHAI
EEEEECCCCCCCCHHEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCEEEC
GDVTSRPQLTPVATRDAGLLARTLFGGSRVAVDHAYVPSAVFSQPEVATVGLTEADARRT
CCCCCCCCCCEECCCCCHHHHHHHCCCCEEEEECCCCCHHHCCCCCEEEEECCHHHHHHH
LGDVDIYRTSFKALRHTLSGRDERTLMKLVVARDSQRVVGAHMVGRDAGEIIQGIAIAIR
HCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHHHEEEE
AGATKAQFDDTIGIHPTAAEEFVTMRQKVAD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]