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The map label for this gene is bmr3 [H]

Identifier: 116690765

GI number: 116690765

Start: 3041906

End: 3043501

Strand: Reverse

Name: bmr3 [H]

Synonym: Bcen2424_2745

Alternate gene names: 116690765

Gene position: 3043501-3041906 (Counterclockwise)

Preceding gene: 116690767

Following gene: 116690764

Centisome position: 87.36

GC content: 67.98

Gene sequence:

>1596_bases
ATGGCCGTTCATACCGCCGCCCACCATTCGAGCGGGCAAGTCCTGCCGTTCCGCGAATCGCTGCTCGCGATGATCGGGAT
CTCGTTCGTCACCATGCTGGTCGCGCTGGACCAGACGGTCGTCGGCACCGCGCTGCCGACCATCGTCGCCGAACTCCGCG
GCTTCGACCTGTACGCGTGGGTCGCGACCTCGTACCTGCTCAGTTCCGTGATCACGGTGCCGATCTTCGGCCGGCTCGGC
GACTATTACGGCCGCAAGCCGTTCGTGATCGCGTCGATCGTCGTGTTTACCGGCGCGTCGGTGCTGTGCGGGATGGCCAA
CGACATGCTGTATCTCGTGCTCGCGCGCGGGCTGCAGGGAATCGGCGGCGGGATGCTGGTCGGCACCGCGTTCGCGTGCA
TTCCCGATCTGTTTCCCGATTCCGTCGTGCGGCTGCGCTGGCAGGTGCTGATGAGCTCGGCGTTCGGTATCGCGAACGCG
GTCGGCCCGTCGCTCGGCGGCGTGCTGACCCAGTCGTTCGGCTGGCGCTCGGTGTTCTATGTGAACCTGCCGATCGGCAT
CCTGTCGCTGTTCTTCGTGTGGCGCTACCTGCCGCACCTGCGCCACGTCGAGCACGACCGCAAGATGCGGCTCGACTGGC
CGGGCGCGCTGTTGATCGCGCTGTCGCTCGGTGCGCTGCAACTGTTCGTCGAATGGCTGCCGAAGTACGGCGTCGCGAGC
TGGGCGTCGCTGCTGCTCGTCGTCGCGGTCGCGGCGGGCATCGGCCTGTGGCACTGGGAAAAGCGCTGCGCGCAGCCGAT
TCTGCCGTTCGACATGTTCGGCAACCGCGCGCTGTCGGCCCTCTTCGTGCTCGCGATCCTCGCCGGTTTCTCGATGTTCT
CGCTCCTGTTCTACGCGCCGTTGCTGTTCCAGGGCGGCTTCGGGATGTCGCCGAGAGAGGCCGGGCTCGTGATCACGCCG
CTCGTCGTGTTCATCACGATCGGCAGCATCATGAACGGCCGCGTCGTCACGCGCATTCGCCATCCGAACACGATGCTGCA
CGTCGGCTTCGTGCTGTTCGCCATCGCGTGCGCGGGCGTCGTCGTGTCGACCCACACGACGCCGACCTGGATGCTGATGG
CGCTGATGGTCGCGGGCGGCATCGGGCTCGGCTTCGTGCTGCCGAACCTCACCGTGTTCGCGCAGCAGACGGCCGGCCGC
GAGCATCTCGGCATCGCCACGGCGCTGTTGCAGTCGCTGCGGATGGTCGGCGGGATGCTCGGCACCGCGCTCACCGGCAC
GCTCGTCAACCAGATGTATTCGGGCGGCGTGCGCGACGCGCTGTCGGGCGACCACGCGATGCAGTGGCACGCGCGGCTCG
CCGATCCGCAGATCCTGATCGATCGCGCGGCGCAGGGCGGTCTCGTCGCGGAGTTGACGCGTGCCGGGCATAATGGCGCG
CTGCTGCTGGAAGCGGCCCGCGAATCGCTGGTCGGCGCGATTCACCTGGGTGTCGCGATGGCGGCCGTCGTCGCCGTGGT
GTCGGTGTGGCAGTGCCGTCGCGTGCCGCCGATCGCGCTGCGGCGCAAGATCGAACCGCACGTCGCGGCCGATTGA

Upstream 100 bases:

>100_bases
CTTGGCCTGAACAGGCCCTGAACCTATCGTCAGCCTAGATTACTCCGGCATGCTAGAATTTTGAGATTATTTGACCCGGC
AAAAGTTGCATCGACAAAAA

Downstream 100 bases:

>100_bases
CCGATCGGGCGAGCGATTCGACGACTCAACGATTCACCGGAACGAAATCAGCGCATGGAAGAACAGGACCGCGTCGCGAT
CTTGCAGCAATTCGGACGCA

Product: major facilitator transporter

Products: NA

Alternate protein names: Multidrug-efflux transporter 3 [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAVHTAAHHSSGQVLPFRESLLAMIGISFVTMLVALDQTVVGTALPTIVAELRGFDLYAWVATSYLLSSVITVPIFGRLG
DYYGRKPFVIASIVVFTGASVLCGMANDMLYLVLARGLQGIGGGMLVGTAFACIPDLFPDSVVRLRWQVLMSSAFGIANA
VGPSLGGVLTQSFGWRSVFYVNLPIGILSLFFVWRYLPHLRHVEHDRKMRLDWPGALLIALSLGALQLFVEWLPKYGVAS
WASLLLVVAVAAGIGLWHWEKRCAQPILPFDMFGNRALSALFVLAILAGFSMFSLLFYAPLLFQGGFGMSPREAGLVITP
LVVFITIGSIMNGRVVTRIRHPNTMLHVGFVLFAIACAGVVVSTHTTPTWMLMALMVAGGIGLGFVLPNLTVFAQQTAGR
EHLGIATALLQSLRMVGGMLGTALTGTLVNQMYSGGVRDALSGDHAMQWHARLADPQILIDRAAQGGLVAELTRAGHNGA
LLLEAARESLVGAIHLGVAMAAVVAVVSVWQCRRVPPIALRRKIEPHVAAD

Sequences:

>Translated_531_residues
MAVHTAAHHSSGQVLPFRESLLAMIGISFVTMLVALDQTVVGTALPTIVAELRGFDLYAWVATSYLLSSVITVPIFGRLG
DYYGRKPFVIASIVVFTGASVLCGMANDMLYLVLARGLQGIGGGMLVGTAFACIPDLFPDSVVRLRWQVLMSSAFGIANA
VGPSLGGVLTQSFGWRSVFYVNLPIGILSLFFVWRYLPHLRHVEHDRKMRLDWPGALLIALSLGALQLFVEWLPKYGVAS
WASLLLVVAVAAGIGLWHWEKRCAQPILPFDMFGNRALSALFVLAILAGFSMFSLLFYAPLLFQGGFGMSPREAGLVITP
LVVFITIGSIMNGRVVTRIRHPNTMLHVGFVLFAIACAGVVVSTHTTPTWMLMALMVAGGIGLGFVLPNLTVFAQQTAGR
EHLGIATALLQSLRMVGGMLGTALTGTLVNQMYSGGVRDALSGDHAMQWHARLADPQILIDRAAQGGLVAELTRAGHNGA
LLLEAARESLVGAIHLGVAMAAVVAVVSVWQCRRVPPIALRRKIEPHVAAD
>Mature_530_residues
AVHTAAHHSSGQVLPFRESLLAMIGISFVTMLVALDQTVVGTALPTIVAELRGFDLYAWVATSYLLSSVITVPIFGRLGD
YYGRKPFVIASIVVFTGASVLCGMANDMLYLVLARGLQGIGGGMLVGTAFACIPDLFPDSVVRLRWQVLMSSAFGIANAV
GPSLGGVLTQSFGWRSVFYVNLPIGILSLFFVWRYLPHLRHVEHDRKMRLDWPGALLIALSLGALQLFVEWLPKYGVASW
ASLLLVVAVAAGIGLWHWEKRCAQPILPFDMFGNRALSALFVLAILAGFSMFSLLFYAPLLFQGGFGMSPREAGLVITPL
VVFITIGSIMNGRVVTRIRHPNTMLHVGFVLFAIACAGVVVSTHTTPTWMLMALMVAGGIGLGFVLPNLTVFAQQTAGRE
HLGIATALLQSLRMVGGMLGTALTGTLVNQMYSGGVRDALSGDHAMQWHARLADPQILIDRAAQGGLVAELTRAGHNGAL
LLEAARESLVGAIHLGVAMAAVVAVVSVWQCRRVPPIALRRKIEPHVAAD

Specific function: Confers resistance to puromycin, tosufloxacin and norfloxacin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=444, Percent_Identity=27.7027027027027, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790195, Length=342, Percent_Identity=28.9473684210526, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788710, Length=516, Percent_Identity=25.1937984496124, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789042, Length=418, Percent_Identity=25.1196172248804, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788392, Length=320, Percent_Identity=27.5, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790146, Length=170, Percent_Identity=32.3529411764706, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=451, Percent_Identity=24.1685144124169, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322958, Length=489, Percent_Identity=24.1308793456033, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323735, Length=485, Percent_Identity=22.0618556701031, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=34.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325455, Length=154, Percent_Identity=32.4675324675325, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324954, Length=404, Percent_Identity=22.7722772277228, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56940; Mature: 56809

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
AVHTAAHHSSGQVLPFRESLLAMIGISFVTMLVALDQTVVGTALPTIVAELRGFDLYAW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH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EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9023234; 9384377 [H]