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The map label for this gene is degP [H]

Identifier: 116690636

GI number: 116690636

Start: 2897298

End: 2898779

Strand: Reverse

Name: degP [H]

Synonym: Bcen2424_2616

Alternate gene names: 116690636

Gene position: 2898779-2897298 (Counterclockwise)

Preceding gene: 116690637

Following gene: 116690635

Centisome position: 83.2

GC content: 68.69

Gene sequence:

>1482_bases
ATGAACACCCGATTCCTTGCGCGCGGCACCGTCGCGGTCGCCGTGGCGGCCGCCCTGTCGGCAGGCTATTTCGCCGGTAC
CCGCCGCGCCGATCCGCAGATCATCACGCCCGCGCAGGCCGCGATGATGCCGGCCGAAGCCGCGGCCAAGACCGGCATTC
CCGATTTCTCCGGGCTCGTCGAGACGTACGGCCCGGCGGTCGTGAACATCAGCGCGAAGCACGTCGTGAAGCAGGTGTCG
CGGCGCGCGCCGCAGCCGCAACTGCCGATCGATCCGAGCGACCCGTTCTACCAGTTCTTCAAGCACTTCTACGGCCAGGT
GCCGGGCATGGGCGGCGACGCGCAGCCGGACGACCAGCCGAGCGCGAGCCTCGGGTCGGGCTTCATCGTCAGCGCCGACG
GGTACATCCTCACCAACGCGCACGTGATCGACGGCGCGAACGTCGTCACGGTCAAGCTGACCGACAAGCGCGAATACAAG
GCGAAGGTCGTCGGCTCCGACAAGCAGTCCGACGTCGCCGTGCTGAAGATCGACGCGAGCGGCCTGCCGACCGTGAAGAT
CGGCGACCCGGCGCAGAGCAAGGTCGGCCAGTGGGTCGTCGCGATCGGCTCGCCGTACGGCTTCGACAACACGGTCACGT
CGGGCATCATCAGCGCGAAGTCGCGCGCGCTGCCGGACGAGAACTACACGCCGTTCATCCAGACCGACGTGCCGGTGAAC
CCCGGCAACTCGGGCGGCCCGCTGTTCAACCTGCAGGGCGAGGTGATCGGTATCAACTCGATGATCTACTCGCAGACGGG
CGGCTTCCAGGGCCTGTCGTTCGCGATCCCGATCAACGAGGCGATCAAGGTGAAGGACGAGCTCGTGAAGACGGGCCACG
TGAGCCGCGGCCGTCTCGGCGTGGCCGTGCAGGGGCTGAACCAGACGCTCGCGAGCTCGTTCGGGCTGCAGAAGCCGGAC
GGCGCGCTCGTCAGCTCGGTCGACCCCAACGGCCCGGCCGCGAAGGCCGGCCTGCAGCCGGGCGACGTGATCCTGTCGGT
CAACGGTTCGCCGGTCGCCGATTCGACGTCGCTGCCCGCGCAGATCGCGAACCTGAAGCCGGGTTCGAAGGCCGACCTGC
AGATCTGGCGCGACAAGTCGAAGAAGTCGATCAGCGTGACGCTCGGCGCGATGGCCGATGCGAAGCTCGCGTCGAACGAC
GGCGGGCCGGTGGAGCAGGGGCGCCTGGGTGTCGCGGTGCGGCCGCTGTCGCCTCAGGAGCGCACCGCCGACAACCTGTC
GCACGGCCTGATCGTGCAGCAGGCCGGCGGGCCGGCCGCCAACGCGGGCATCCAGCCGGGCGACGTGATTCTCGCGGTCA
ACGGCCGCCCGGTCACGAGCCCGGAGCAATTGCGCGACGCGGTGAAGGGCGCGGGCAACAGTCTTGCTCTGCTGATCCAG
CGCGATAATGCACAGATCTTCGTGCCGGTCGACCTGAGCTGA

Upstream 100 bases:

>100_bases
GGCCGGATGCCGGCAGCCGCTTAAGCCCCGCTTAAGGCTGATTAAGCCTCCTTTAAGTCAGGGTCGTTACGCTGCGTCCT
AACAACGAGGAGGTCCTACG

Downstream 100 bases:

>100_bases
CCGGCCACGGCCGACGGCCGGCCTGGCCGGCCGCGGCGGGCGCCGCCGCCGTTCGATCGCGCGACGCCGCGCCCCGTATG
TGTTCCGACCCCAAGGAGAG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MNTRFLARGTVAVAVAAALSAGYFAGTRRADPQIITPAQAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQVS
RRAPQPQLPIDPSDPFYQFFKHFYGQVPGMGGDAQPDDQPSASLGSGFIVSADGYILTNAHVIDGANVVTVKLTDKREYK
AKVVGSDKQSDVAVLKIDASGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVN
PGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQKPD
GALVSSVDPNGPAAKAGLQPGDVILSVNGSPVADSTSLPAQIANLKPGSKADLQIWRDKSKKSISVTLGAMADAKLASND
GGPVEQGRLGVAVRPLSPQERTADNLSHGLIVQQAGGPAANAGIQPGDVILAVNGRPVTSPEQLRDAVKGAGNSLALLIQ
RDNAQIFVPVDLS

Sequences:

>Translated_493_residues
MNTRFLARGTVAVAVAAALSAGYFAGTRRADPQIITPAQAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQVS
RRAPQPQLPIDPSDPFYQFFKHFYGQVPGMGGDAQPDDQPSASLGSGFIVSADGYILTNAHVIDGANVVTVKLTDKREYK
AKVVGSDKQSDVAVLKIDASGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVN
PGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQKPD
GALVSSVDPNGPAAKAGLQPGDVILSVNGSPVADSTSLPAQIANLKPGSKADLQIWRDKSKKSISVTLGAMADAKLASND
GGPVEQGRLGVAVRPLSPQERTADNLSHGLIVQQAGGPAANAGIQPGDVILAVNGRPVTSPEQLRDAVKGAGNSLALLIQ
RDNAQIFVPVDLS
>Mature_493_residues
MNTRFLARGTVAVAVAAALSAGYFAGTRRADPQIITPAQAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQVS
RRAPQPQLPIDPSDPFYQFFKHFYGQVPGMGGDAQPDDQPSASLGSGFIVSADGYILTNAHVIDGANVVTVKLTDKREYK
AKVVGSDKQSDVAVLKIDASGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVN
PGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLQKPD
GALVSSVDPNGPAAKAGLQPGDVILSVNGSPVADSTSLPAQIANLKPGSKADLQIWRDKSKKSISVTLGAMADAKLASND
GGPVEQGRLGVAVRPLSPQERTADNLSHGLIVQQAGGPAANAGIQPGDVILAVNGRPVTSPEQLRDAVKGAGNSLALLIQ
RDNAQIFVPVDLS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=255, Percent_Identity=38.8235294117647, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI22129776, Length=265, Percent_Identity=37.3584905660377, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI7019477, Length=281, Percent_Identity=36.6548042704626, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308541, Length=253, Percent_Identity=35.9683794466403, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1786356, Length=465, Percent_Identity=35.6989247311828, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=35.7298474945534, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=40.2214022140221, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24646839, Length=296, Percent_Identity=35.1351351351351, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50958; Mature: 50958

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRFLARGTVAVAVAAALSAGYFAGTRRADPQIITPAQAAMMPAEAAAKTGIPDFSGLV
CCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHCCHHHHHHCCCCCHHHHH
ETYGPAVVNISAKHVVKQVSRRAPQPQLPIDPSDPFYQFFKHFYGQVPGMGGDAQPDDQP
HHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
SASLGSGFIVSADGYILTNAHVIDGANVVTVKLTDKREYKAKVVGSDKQSDVAVLKIDAS
CCCCCCCEEEECCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCC
GLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVN
CCCEEEECCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
PGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLG
CCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEE
VAVQGLNQTLASSFGLQKPDGALVSSVDPNGPAAKAGLQPGDVILSVNGSPVADSTSLPA
EEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCCCCCCH
QIANLKPGSKADLQIWRDKSKKSISVTLGAMADAKLASNDGGPVEQGRLGVAVRPLSPQE
HHHCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEEECCCCHH
RTADNLSHGLIVQQAGGPAANAGIQPGDVILAVNGRPVTSPEQLRDAVKGAGNSLALLIQ
HHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
RDNAQIFVPVDLS
ECCCEEEEEEECC
>Mature Secondary Structure
MNTRFLARGTVAVAVAAALSAGYFAGTRRADPQIITPAQAAMMPAEAAAKTGIPDFSGLV
CCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHCCHHHHHHCCCCCHHHHH
ETYGPAVVNISAKHVVKQVSRRAPQPQLPIDPSDPFYQFFKHFYGQVPGMGGDAQPDDQP
HHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
SASLGSGFIVSADGYILTNAHVIDGANVVTVKLTDKREYKAKVVGSDKQSDVAVLKIDAS
CCCCCCCEEEECCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCC
GLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPVN
CCCEEEECCCCHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
PGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLG
CCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEE
VAVQGLNQTLASSFGLQKPDGALVSSVDPNGPAAKAGLQPGDVILSVNGSPVADSTSLPA
EEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCCCCCCCCCH
QIANLKPGSKADLQIWRDKSKKSISVTLGAMADAKLASNDGGPVEQGRLGVAVRPLSPQE
HHHCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEECCCCCCCCCCCCCCEEEECCCCHH
RTADNLSHGLIVQQAGGPAANAGIQPGDVILAVNGRPVTSPEQLRDAVKGAGNSLALLIQ
HHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
RDNAQIFVPVDLS
ECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]