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The map label for this gene is fghA [H]

Identifier: 116690623

GI number: 116690623

Start: 2880886

End: 2881734

Strand: Reverse

Name: fghA [H]

Synonym: Bcen2424_2603

Alternate gene names: 116690623

Gene position: 2881734-2880886 (Counterclockwise)

Preceding gene: 116690624

Following gene: 116690618

Centisome position: 82.72

GC content: 69.96

Gene sequence:

>849_bases
ATGCTCGAACTCGTTTCCTCGCATGCGTGCCACGGCGGCGAGCAGCGTTTCTACCGTCACGATTCGGCGGCCATCGGCCT
GCCGATGAAGTTCTCGGTGTATCTGCCGCCGCAGGCCGCGCACGGGCGCGTGCCGGCGCTGTTCTATCTCGCGGGGCTCA
CGTGCACCGACGAGACGTTCGCGATCAAGGCCGGCGCGCAGCAATACGCGGCGCGGCACGGCATCGCGCTCGTGATGCCC
GACACGAGCCCGCGCGGCGCGGGCGTGCCGGGCGAGACCGATGCGTGGGACTTCGGCGTCGGCGCGGGTTTCTACGTCGA
TGCGACCGAAGCGCCGTGGTCGACGCATTACCGGATGGAGTCGTACGTGACGGGCGAGCTGCGCGAGCTCGTCACGGCCG
AGCTGCCGATCGACGGCGCGCGGCTCGGCATCTTCGGTCACTCGATGGGCGGGCACGGGGCGCTGACGCTCGCGTTGCGT
CATCCGGGCCTGTACCGGTCGGTGTCGGCGTTCGCGCCGATCGCCGCGCCGACGCGCTGCCCGTGGGGCGAGAAGGCGTT
CTCCGGTTATCTCGGCGCCGATCGCGAGACGTGGAAGGCGCACGACGCGAGCGAGCTCGTCGCGCGCGCCGATGCGCCGA
AGTTCGCGGACGGCATCCTCGTCGATCAGGGGCTGGCCGACCAGTTCCTCGCGAACCAGCTGAACCCGGACGTATTCGAA
GCCGCGTGCGCGAAGGCCGGCCAGCCGCTGACGCTGCGCCGCCATCCGGGCTACGACCACGGCTACTACTTCATCTCGAC
GTTCATCGCCGACCACCTCGCACATCATGCGCGTGTGCTGGCGCGGTGA

Upstream 100 bases:

>100_bases
GCACACGCTGCCGCTCGAGCGGATCAACGAAGGCTTCGACCTGATGAAGGCCGGCGAGTCGATCCGCTCGGTCGTGCTGT
ACTGACCGGAGCGCACCGCC

Downstream 100 bases:

>100_bases
GCCGGAACCGACACACGTCGCGCATATGGCGCGCCGCGACGTAATCGCGGGCGCATGAAAAAACGCCGGCGCTGCCCTCG
GGCACGCCGGCGTTTTCATT

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAARHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSTHYRMESYVTGELRELVTAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADRETWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHPGYDHGYYFISTFIADHLAHHARVLAR

Sequences:

>Translated_282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAARHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSTHYRMESYVTGELRELVTAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADRETWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHPGYDHGYYFISTFIADHLAHHARVLAR
>Mature_282_residues
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETFAIKAGAQQYAARHGIALVMP
DTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSTHYRMESYVTGELRELVTAELPIDGARLGIFGHSMGGHGALTLALR
HPGLYRSVSAFAPIAAPTRCPWGEKAFSGYLGADRETWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
AACAKAGQPLTLRRHPGYDHGYYFISTFIADHLAHHARVLAR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=56.4285714285714, Blast_Score=345, Evalue=4e-95,
Organism=Escherichia coli, GI1788477, Length=281, Percent_Identity=51.9572953736655, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1786551, Length=279, Percent_Identity=46.9534050179211, Blast_Score=276, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=49.4661921708185, Blast_Score=285, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=38.3838383838384, Blast_Score=199, Evalue=4e-52,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=53.9007092198582, Blast_Score=306, Evalue=9e-84,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=53.9007092198582, Blast_Score=305, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30434; Mature: 30434

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETF
CCCCCCCCCCCCCHHHHEECCCCEECCCEEEEEEECCCCCCCCCCEEEHEECCEECCCEE
AIKAGAQQYAARHGIALVMPDTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSTHYRME
EEECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHEEHH
SYVTGELRELVTAELPIDGARLGIFGHSMGGHGALTLALRHPGLYRSVSAFAPIAAPTRC
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCC
PWGEKAFSGYLGADRETWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
CCCHHHHHCCCCCCCHHHCCCCHHHHHHHCCCCCHHCCEEECCCHHHHHHHHCCCHHHHH
AACAKAGQPLTLRRHPGYDHGYYFISTFIADHLAHHARVLAR
HHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELVSSHACHGGEQRFYRHDSAAIGLPMKFSVYLPPQAAHGRVPALFYLAGLTCTDETF
CCCCCCCCCCCCCHHHHEECCCCEECCCEEEEEEECCCCCCCCCCEEEHEECCEECCCEE
AIKAGAQQYAARHGIALVMPDTSPRGAGVPGETDAWDFGVGAGFYVDATEAPWSTHYRME
EEECCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHEEHH
SYVTGELRELVTAELPIDGARLGIFGHSMGGHGALTLALRHPGLYRSVSAFAPIAAPTRC
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCC
PWGEKAFSGYLGADRETWKAHDASELVARADAPKFADGILVDQGLADQFLANQLNPDVFE
CCCHHHHHCCCCCCCHHHCCCCHHHHHHHCCCCCHHCCEEECCCHHHHHHHHCCCHHHHH
AACAKAGQPLTLRRHPGYDHGYYFISTFIADHLAHHARVLAR
HHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]