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The map label for this gene is argH

Identifier: 116690449

GI number: 116690449

Start: 2696677

End: 2698086

Strand: Direct

Name: argH

Synonym: Bcen2424_2429

Alternate gene names: 116690449

Gene position: 2696677-2698086 (Clockwise)

Preceding gene: 116690448

Following gene: 116690450

Centisome position: 77.4

GC content: 68.09

Gene sequence:

>1410_bases
ATGACGTCCCAACTGCACAAAAAGGGCGAGGCCTGGTCGGCCCGCTTCTCGGAACCGATGTCGGAGCTGGTCAAGCGCTA
CACGTCGTCGGTGTTTTTCGACAAGCGCCTCGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGAACATGCTCGCCG
CGCAGAAGATCATCAACGCCGACGACCTCGCCGCGATCGAACGCGGGATGGCGCAGATCAAGGGCGAGATCGAGCGCGGC
GAATTCGAATGGCAGCTCGACCTGGAAGACGTCCACCTGAACATCGAGGCGCGCCTGACCGCGCTGATCGGCGATGCCGG
CAAGCGCCTGCACACGGGCCGCTCGCGCAACGACCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCGGCGAGATCGACC
GCATCGGCGGCCTGCTGAACGACCTGCGCGGCGCGCTGATCGACCTCGCGGAACAGAACGCCGATACGATCATGCCCGGC
TTCACGCACCTGCAGGTCGCGCAGCCGGTCACGTTCGGCCACCACCTGCTCGCGTACGTCGAGATGTTCACGCGCGACGC
CGAACGCATGCGCGACTGCCGCACCCGCGTGAACCGCCTGCCGCTCGGCGCGGCCGCGCTCGCGGGCACGAGCTACCCGA
TCGACCGTCACGCGGTCGCGAAGACGCTCGGCTTCGACGGCATCTGCGCGAACTCGCTCGACGCGGTGTCCGATCGCGAC
TTCGCGATCGAATTCACGGCGGCGTCCGCGCTCGTGATGACGCACGTGTCGCGCTTCTCCGAAGAACTCGTGCTGTGGAT
GAGCCCGCGCGTCGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAGCTCGCGCGCGGCAAGACCGGCCGCGTGAACGGCCACCTGATGGCGCTCCTCACGCTGATGAAGGGCCAG
CCGCTCGCGTACAACAAGGACAACCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCG
GATCTTCGCCGAGATGGTCGCCGGCATCACCGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCG
CCACCGACCTCGCCGACTACCTGGTCAAGCGCGGCCTGCCGTTCCGCGACGCGCACGAAGCCGTCGCGCACGCGGTGAAG
ATCTGCGACGACCGCGGCATCGACCTCGCCGACCTGACGCTCGACGAGATGAAGCAGGAACTGCCGAACGTCGCGCACCT
GATCGGCGACGACGTGTTCGGCTACCTGACGCTCGAAGGGTCGGTCGCGAGCCGCAACCATCCGGGCGGCACCTCGCCCG
ATCAGGTGCGTGCGGCCGTCAAGGCGGCCCGCGCCGCGCTGGCCAAGTAA

Upstream 100 bases:

>100_bases
CGGCCCCCGCGCCGGCGGCGGTCGGCCGGCCCGCGAATGTTAGAATCGCGGGATTCCCTCGGCGGCTCACGGCCGCCCAA
CTCCCCTTCGAAGAATCGCC

Downstream 100 bases:

>100_bases
CGGCCTGCGGTTCCGGACGGACGCCTTCGGCGTCCGTTTTTCATTCGGGCGGCCCTCGCGCCGCCCGCTGCTTTCCCCGC
TTCACGGATGCCCCCGATGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIINADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
ICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHPGGTSPDQVRAAVKAARAALAK

Sequences:

>Translated_469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIINADDLAAIERGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPG
FTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
ICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHPGGTSPDQVRAAVKAARAALAK
>Mature_468_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIINADDLAAIERGMAQIKGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPGF
THLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDF
AIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKI
CDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHPGGTSPDQVRAAVKAARAALAK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.4793926247288, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.4793926247288, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.3101952277657, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=36.8763557483731, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=44.8577680525164, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=40.5228758169935, Blast_Score=333, Evalue=3e-92,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.2932166301969, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.2932166301969, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_BURCA (Q1BUI4)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_621694.1
- ProteinModelPortal:   Q1BUI4
- SMR:   Q1BUI4
- STRING:   Q1BUI4
- GeneID:   4093363
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_1818
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   BCEN331271:BCEN_1818-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51380; Mature: 51249

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIINA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGDDVFGYLTLEGSVASRNHPGGTSPDQVRAAVKAARAALAK
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIINA
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHH
EMFTRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
FAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGDDVFGYLTLEGSVASRNHPGGTSPDQVRAAVKAARAALAK
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA