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The map label for this gene is nuoL [H]

Identifier: 116690259

GI number: 116690259

Start: 2492252

End: 2494306

Strand: Reverse

Name: nuoL [H]

Synonym: Bcen2424_2238

Alternate gene names: 116690259

Gene position: 2494306-2492252 (Counterclockwise)

Preceding gene: 116690260

Following gene: 116690258

Centisome position: 71.6

GC content: 63.16

Gene sequence:

>2055_bases
ATGTCAACGACACTCAATGAAAACCTGCTGCTGGCGATTCCGCTCGCTCCGCTGGCCGGCTCGCTGATTGCGGGGCTGTT
CGGGAACGCAGTCGGGCGCAAGGGCGCACACCGGATCACGATCCTCGGCGTATTGATCGCGTTCCTCCTGTCGGCGAAAG
TCTTCTTCGACGTGATGGGCGGCGCAAGCTTCAACGCGACCGTCTACGAATGGATGAACGTCGGCTCGCTGAAGCTCGAA
GTCGGCTTCCTCGTCGATTCGCTGACCGCGATGATGATGGTCGTCGTGACCTTCGTCTCGCTGATGGTGCACGTGTACAC
GATCGGCTACATGGCGGAGGAAGACGGCTACCAGCGCTTCTTCTCGTACATCTCGCTGTTCACGTTCTCGATGCTGATGC
TCGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGTCTGGTGTCGTACCTGCTGATCGGCTTC
TACTTCACGCGTGAGAGCGCGATCTACGCGAACATGAAGGCGTTCCTCGTGAACCGCGTGGGCGACTTCGGCTTCCTGCT
CGGCATCGGCCTGTTGCTCGCGTTCGCCGGCTCGATGAACTACGGCGAAGTGTTCGCGAAGCGCGCCGAACTGGCGAGCC
TGCACTTCCCGGGCACCGACTGGGGCCTGCTGACCGTTGCCTGTATCTGCCTGTTCATCGGCGCGATGGGTAAGTCGGCC
CAGTTCCCGCTGCACGTGTGGCTGCCGGACTCGATGGAAGGCCCGACCCCGATCTCGGCGCTGATTCACGCGGCGACGAT
GGTGACGGCCGGCATCTTCATGGTGTCGCGCATGTCGCCGCTGTTCGAACTGTCGGATACCGCGCTGTCGTTCATCACGG
TGATCGGCGCGATCACGGCGCTCTTCATGGGCTTCCTGGGCATCGTCCAGAACGACATCAAGCGCGTGGTCGCGTACTCG
ACGCTGTCGCAGCTCGGCTACATGACCGTCGCGCTCGGCGTGTCCGCTTACCCGGTCGCCGTGTTCCACCTGATGACGCA
CGCGTTCTTCAAGGCGCTGCTGTTCCTCGGCGCCGGCTCGGTCATCATGGGCATGCACCACGACCAGGACATGCGCAACA
TGGGCGGCCTGCGCAAGTACATGCCGATCACGTGGATCACGTCGCTCGTCGGTTCGCTCGCGCTGATCGGCACGCCGTTC
TTCTCGGGCTTCTACTCGAAGGACTCGATCATCGACGCGGTGAAGCTGTCGCACCTGCCGGGTTCGGGCTTCGCGTACTT
CGCGGTCGTCGCGAGCGTGTTCGTCACGGCGCTGTACTCGTTCCGCATGTACTTCCTGGTGTTCCACGGCGAGGAGCGCT
TCCGCAAGCCGAAGCATCCGGAATCGCCGATGGGCATGGCGGCCGCGCACGGTCACGACGATCACGGCCATGGCCACGGT
CATGACGACCACGCGCACGAGCCGCACGAGACCCCGTGGGTCGTGTGGGTGCCGCTGGTCCTGCTGGCGATCCCGTCGGT
GATCATCGGCGCGATCGCGATCAGCCCGATGCTGTTCGGCGATTTCTTCCAGCACGGCGTCGCATTCGACAAGGTGATCT
TCATCGGCGAAAACCATCCGGCACTCGCCGAGATGGCCGAAGAGTTCCACGGCTGGGTTGGCATGGGCCTGCACTCGGTG
TCGGGCCTGCCGGTGTGGCTGGCGCTTGCCGGCGTGGTCGTCGCGTGGTTCCTGTACCTGAAGCGTCCGGAGCTGCCGGC
GTCGATCCGCCGCGCGTTCGGCCCGATCTACACGCTGCTGGACAACAAGTACTACATGGACAAGATCAACGAAGTGGTGT
TCGCCCGGGGTTCGGTGGCGATCGGCCGCGGCCTGTGGAAGGAGGGTGACGTCGTGGTGATCGACGGCCTCGTCAACGGC
AGCGCCCGGTTCATCGGCTGGTTCGCCGGCGTGATCCGCTTCCTCCAATCCGGTTACATCTATCACTACGCGTTCGCCAT
GATCATCGGCATGCTGGGGCTCCTGACCCTGTTTGTAACGCTCGGCGGCAAATAA

Upstream 100 bases:

>100_bases
CGATCGGCCTCGCGATTCTGGTGACCCTGTTCCGTAAGCTCGACACGATCAATGTCGAGGATCTCGATCAGCTCAAAGGT
TAATTTCAGGCTACGCTGTT

Downstream 100 bases:

>100_bases
GGCGGGGAGACAACACTAATGCACGCTTTTCCGATTCTCAGTACCGCGATCTGGCTGCCGATCGTTTTCGGCCTCCTCGT
GCTGGCGGTAGGTAACGACA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Sequences:

>Translated_684_residues
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLE
VGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGF
YFTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYS
TLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPF
FSGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSV
SGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNG
SARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK
>Mature_683_residues
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFFDVMGGASFNATVYEWMNVGSLKLEV
GFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFY
FTRESAIYANMKAFLVNRVGDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSAQ
FPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITALFMGFLGIVQNDIKRVVAYST
LSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGSVIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFF
SGFYSKDSIIDAVKLSHLPGSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHGH
DDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAISPMLFGDFFQHGVAFDKVIFIGENHPALAEMAEEFHGWVGMGLHSVS
GLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLLDNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGS
ARFIGWFAGVIRFLQSGYIYHYAFAMIIGMLGLLTLFVTLGGK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=386, Percent_Identity=40.4145077720207, Blast_Score=288, Evalue=9e-78,
Organism=Escherichia coli, GI1788614, Length=617, Percent_Identity=38.2495948136143, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1788829, Length=416, Percent_Identity=29.3269230769231, Blast_Score=152, Evalue=8e-38,
Organism=Escherichia coli, GI1788831, Length=352, Percent_Identity=30.1136363636364, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1788827, Length=464, Percent_Identity=28.0172413793103, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI2367154, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788613, Length=332, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693160, Length=321, Percent_Identity=25.2336448598131, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74844; Mature: 74713

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFFDVMG
CCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
HEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAISPMLFGDFFQHGVAFDKVIFIGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTLNENLLLAIPLAPLAGSLIAGLFGNAVGRKGAHRITILGVLIAFLLSAKVFFDVMG
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
GASFNATVYEWMNVGSLKLEVGFLVDSLTAMMMVVVTFVSLMVHVYTIGYMAEEDGYQRF
CCCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFYFTRESAIYANMKAFLVNRV
HHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
GDFGFLLGIGLLLAFAGSMNYGEVFAKRAELASLHFPGTDWGLLTVACICLFIGAMGKSA
CHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCC
QFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFITVIGAITA
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LFMGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYPVAVFHLMTHAFFKALLFLGAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCH
VIMGMHHDQDMRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSIIDAVKLSHLP
HEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHCCC
GSGFAYFAVVASVFVTALYSFRMYFLVFHGEERFRKPKHPESPMGMAAAHGHDDHGHGHG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCHHCCCCCCCCCCCC
HDDHAHEPHETPWVVWVPLVLLAIPSVIIGAIAISPMLFGDFFQHGVAFDKVIFIGENHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
ALAEMAEEFHGWVGMGLHSVSGLPVWLALAGVVVAWFLYLKRPELPASIRRAFGPIYTLL
HHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DNKYYMDKINEVVFARGSVAIGRGLWKEGDVVVIDGLVNGSARFIGWFAGVIRFLQSGYI
CCCHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCH
YHYAFAMIIGMLGLLTLFVTLGGK
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]