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The map label for this gene is nuoN [H]

Identifier: 116690257

GI number: 116690257

Start: 2489252

End: 2490718

Strand: Reverse

Name: nuoN [H]

Synonym: Bcen2424_2236

Alternate gene names: 116690257

Gene position: 2490718-2489252 (Counterclockwise)

Preceding gene: 116690258

Following gene: 116690256

Centisome position: 71.49

GC content: 64.55

Gene sequence:

>1467_bases
ATGAACGCTCCTATGAATGTCCTGTTGCCCGACGCGCTGGTGATGGCCGCCATCGTCGTCGCATGGCTGAACGACACCTT
TGCCGGTGCTTCCGGTCGCCGCCTGACCTATCTGATCGCAGTCGTCTCGTCGGTGGTCGCCGGCGTGTGGTTCGCGGTCC
AGGCGCTCGACCCGCAGCCGTACTACTTCTTCTCGAAGATGATCGTCGTCGACTCGTTCGCGAGCATGATGAAGGCGGTC
GTGTCGTTCGGTTTCGCGGTCTCGCTCGTCTATTCGCGCAAGTACCTCGAAGACCGCGACATGTTCCGCGGCGACGTGTT
CCTGCTCGGCATGTTCTCGCTGCTCGGTCAGCTGGTCATGGTGTCGGGCAACAACTTCCTGACGCTGTACCTCGGCCTCG
AACTGATGTCGCTGTCGCTGTACGCGGTCATCGCGCTGCGCCGCGACGCCGCACAGTCGAGCGAAGCCGCGATGAAGTAC
TACGTGCTGGGCGCGCTCGCGTCGGGCTTCGTGCTGTACGGCATCTCGATGCTCTACGGCGCGACCGGCTCGCTCGAACT
GGGTGAGGTGTACAAGGCGGTCGGCGGCAACACCGACGCGGCCGTGCTGATGTTCGGCGTGATCTTCATCGTCGCCGGTA
TCGCGTTCAAGCTCGGCGCCGTGCCGTTCCACATGTGGGTGCCGGACGTCTACCAGGGCGCACCGACCGCGATGACGCTG
TTCGTCGGCGGCGGCCCGAAGGTTGCCGCGTTCGCATGGGGCCTGCGCTTCCTGGTGATGGGCCTGCTGCCGCTCGCCCA
GAACTGGCAGACCGCGCTCGTGATCCTCGCCGCGCTGTCGCTGATCGTCGGTAACATCACCGGTATCGTCCAGCGCAACA
TCAAGCGGATGCTCGCGTACTCGGCGATCTCGAACATGGGCTTCGTGCTGCTCGGCCTGCTCGCGGGCATCGTGAAGGGC
GACGCGGCGGCACCGGCGAACGCGTACAGCTCGGCGATGTTCTACGCGATCGTCTACCTGATCACGACGCTCGGCTCGTT
CGGCGTGGTGATGCTGCTCGCGCGCCGCGATTTCGAAGCGGAAACGATCGACGACTTCAAGGGCCTCAACAAGCGCAGCC
CGGTGTTCGCGTTCGTGATGATGGTCATGATGTTCTCGCTGGCCGGCATCCCGCCGACCGTCGGCTTCTACGCGAAGCTG
GCCGTGCTCGAGGCGACCGTCAACGCGGGCCTCACGTGGCTGGCCGTGCTGGCCGTGATCACGTCGCTGTTCGGTGCGTT
CTACTACCTGCGCATCGTGAAGCTGATGTACTTCGATGCCCCGCAGGATTCGACGCCGATCTCGGGCGATTTCTGCAAGC
GCACGATCCTCGTGCTGAACGGCCTGGCGGTCGTCGTGCTCGGCCTGATCCCGAGCCCGCTGCTGACTGCCTGCCTGCAG
GCAATCCGTCACACGCTGCCGCTGTAA

Upstream 100 bases:

>100_bases
CACCGACGTGATGCACGTTTCCGTCGAAAACCTCCTCTCCCACGTCGCGCAGTCGAAGCTGCCGCTGGCCCAGTAATCGC
GAGCGGAGGAACTCAAGATC

Downstream 100 bases:

>100_bases
TGTCGGCAGCCGGCTGGTTCATCGTGCTGTTGGCGCTCGTCTGCGCCAACCTGCCGTTCCTGAACCAACGCCTCTTCGCC
GTCGTGCCGTTCGGCGCGAC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MNAPMNVLLPDALVMAAIVVAWLNDTFAGASGRRLTYLIAVVSSVVAGVWFAVQALDPQPYYFFSKMIVVDSFASMMKAV
VSFGFAVSLVYSRKYLEDRDMFRGDVFLLGMFSLLGQLVMVSGNNFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMKY
YVLGALASGFVLYGISMLYGATGSLELGEVYKAVGGNTDAAVLMFGVIFIVAGIAFKLGAVPFHMWVPDVYQGAPTAMTL
FVGGGPKVAAFAWGLRFLVMGLLPLAQNWQTALVILAALSLIVGNITGIVQRNIKRMLAYSAISNMGFVLLGLLAGIVKG
DAAAPANAYSSAMFYAIVYLITTLGSFGVVMLLARRDFEAETIDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYAKL
AVLEATVNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDAPQDSTPISGDFCKRTILVLNGLAVVVLGLIPSPLLTACLQ
AIRHTLPL

Sequences:

>Translated_488_residues
MNAPMNVLLPDALVMAAIVVAWLNDTFAGASGRRLTYLIAVVSSVVAGVWFAVQALDPQPYYFFSKMIVVDSFASMMKAV
VSFGFAVSLVYSRKYLEDRDMFRGDVFLLGMFSLLGQLVMVSGNNFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMKY
YVLGALASGFVLYGISMLYGATGSLELGEVYKAVGGNTDAAVLMFGVIFIVAGIAFKLGAVPFHMWVPDVYQGAPTAMTL
FVGGGPKVAAFAWGLRFLVMGLLPLAQNWQTALVILAALSLIVGNITGIVQRNIKRMLAYSAISNMGFVLLGLLAGIVKG
DAAAPANAYSSAMFYAIVYLITTLGSFGVVMLLARRDFEAETIDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYAKL
AVLEATVNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDAPQDSTPISGDFCKRTILVLNGLAVVVLGLIPSPLLTACLQ
AIRHTLPL
>Mature_488_residues
MNAPMNVLLPDALVMAAIVVAWLNDTFAGASGRRLTYLIAVVSSVVAGVWFAVQALDPQPYYFFSKMIVVDSFASMMKAV
VSFGFAVSLVYSRKYLEDRDMFRGDVFLLGMFSLLGQLVMVSGNNFLTLYLGLELMSLSLYAVIALRRDAAQSSEAAMKY
YVLGALASGFVLYGISMLYGATGSLELGEVYKAVGGNTDAAVLMFGVIFIVAGIAFKLGAVPFHMWVPDVYQGAPTAMTL
FVGGGPKVAAFAWGLRFLVMGLLPLAQNWQTALVILAALSLIVGNITGIVQRNIKRMLAYSAISNMGFVLLGLLAGIVKG
DAAAPANAYSSAMFYAIVYLITTLGSFGVVMLLARRDFEAETIDDFKGLNKRSPVFAFVMMVMMFSLAGIPPTVGFYAKL
AVLEATVNAGLTWLAVLAVITSLFGAFYYLRIVKLMYFDAPQDSTPISGDFCKRTILVLNGLAVVVLGLIPSPLLTACLQ
AIRHTLPL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=329, Percent_Identity=25.8358662613982, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI145693160, Length=501, Percent_Identity=33.7325349301397, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1788614, Length=416, Percent_Identity=25.2403846153846, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788827, Length=360, Percent_Identity=25.2777777777778, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788831, Length=306, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI2367154, Length=148, Percent_Identity=27.7027027027027, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788613, Length=449, Percent_Identity=24.9443207126949, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52441; Mature: 52441

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA