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The map label for this gene is pyrG [H]

Identifier: 116690130

GI number: 116690130

Start: 2338858

End: 2340516

Strand: Reverse

Name: pyrG [H]

Synonym: Bcen2424_2109

Alternate gene names: 116690130

Gene position: 2340516-2338858 (Counterclockwise)

Preceding gene: 116690131

Following gene: 116690129

Centisome position: 67.18

GC content: 63.23

Gene sequence:

>1659_bases
ATGACCAAATATGTTTTCGTCACCGGCGGCGTAGTTTCTTCCCTTGGCAAGGGCATTGCCGCCGCTTCCCTCGCCGCGAT
CCTCGAATCGCGCGGTCTGAAAGTCACCCTCCTCAAGCTTGATCCCTACATCAACGTCGACCCCGGCACGATGAGCCCGT
TTCAACACGGCGAAGTGTTCGTGACGGAAGACGGAGCGGAGACCGACCTCGACCTCGGCCACTACGAGCGCTTCATCAGC
ACGAAGATGCGCAAGGCCAACAACTTCACGACCGGCCAGATCTACGAATCGGTGATCCGCAAGGAACGCCGCGGCGACTA
TCTCGGCAAGACCGTGCAGGTCATTCCGCACATCACGAACGAAATCCAGGCGTTCATCGAGCGCGGGGCCGCATCGGCCA
CCTGCGGCGAGCCGGACGTCGCGATCGTCGAGATCGGCGGCACGGTCGGCGACATCGAGTCGCTGCCGTTCCTCGAGGCC
GCACGCCAGATGAGCCTGCGCCTCGGCCGCAACAGCGCGTGCTTCGTGCACCTGACGCTCGTGCCGTACGTCGCGACGGC
CGGCGAGCTGAAGACGAAGCCGACCCAGCACAGCGTGCAGAAGCTGCGCGAGATCGGCATCCTGCCGCACGTGCTGCTGT
GCCGTGCGGATCGCCGCATCCCCGACGACGAATCGAAGAAGATCTCGATGTTCTCGAACGTGCCGGAAGACGCCGTGATC
TCGGTGTGGGATGCCGACAGCATCTACAAGATTCCGCAGATGCTGCACGACCAGGGCCTCGACCGGATCATCTGCGAAGA
GCTGAAGCTGTCGCCCAAGGACGCCGACCTGAGCATGTGGTCGGCGCTCGTCGAGAAGCTCGAGAACCCGAAGCAGGAAG
TGACGATCGGCATGGTCGGCAAGTACGTCGACCTGACCGAGTCGTACAAGTCGCTGATCGAGGCGCTGCGCCATGCGTCG
ATCCACACGTCGACCAAGGTCAACATCGAGTACATCGACTCGGAAGAGCTCGAGACCAACGGTGTCGACAGCCTGAAGCA
TCTCGACGCCGTGCTGGTGCCGGGCGGTTTCGGCCGTCGCGGCACGGAAGGCAAGATCGCCGCGGTTCGCTACGCGCGCG
AGTCGAAGGTGCCGTACCTCGGCATCTGCCTCGGCATGCAGCTCGCGGTGATCGAATTCGCGCGCGACGTCGTCGGCCTG
AAGCAGGCGAACAGCACGGAATTCGATCCGGACACGCCGGAGCGTGTGGTCGCGCTGATCACCGAATGGTACGACCGCGA
AGGCAAGGTCGAGACGCGCACCGAGGAATCCGACCTCGGCGGCACGATGCGCCTGGGTTCGCAACGCTGCCCGATCAAGC
CGGGCACGATGGCGGAAGAAATCTACGGCAAGGACGTGAACGAGCGCCATCGCCACCGTTATGAAGTCAATAACCGCTTC
GTGCCCCAGCTCGAAGCCGGCGGCCTTATCATCAGCGCCCGTACCCCGAGCGAGGATCTGCCGGAAATGATGGAACTGCC
GCGTTCGATGCACCCGTGGTTCGTCGGCGTCCAGTTCCACCCGGAATTCACGTCCACGCCGCGTGACGGTCATCCTCTGT
TCAGGTCGTTCGTCGAAGCGGCGCTTGCCAACAAGCAAGCGCGCGGAGTGCAAGCATGA

Upstream 100 bases:

>100_bases
TCGGCACGGATTGGCCCGAACGGGGCGCGATCATCACGCCAATTGCTGAGAGAAGGGCGGGCTTTACGGTATAATCCGTT
TTTCCCGCGAGCATCCAGCG

Downstream 100 bases:

>100_bases
AGCTGTGCGATTTCGAGGTCGGTCTCGACCAGCCTTTCTTCCTGATCGCGGGTACCTGCGTCGTCGAATCGGAGCAAATG
ACGATCGACACGGCGGGCCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSALVEKLENPKQEVTIGMVGKYVDLTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAVRYARESKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPDTPERVVALITEWYDREGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFRSFVEAALANKQARGVQA

Sequences:

>Translated_552_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSALVEKLENPKQEVTIGMVGKYVDLTESYKSLIEALRHAS
IHTSTKVNIEYIDSEELETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAVRYARESKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPDTPERVVALITEWYDREGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFRSFVEAALANKQARGVQA
>Mature_551_residues
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIST
KMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAA
RQMSLRLGRNSACFVHLTLVPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVIS
VWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSALVEKLENPKQEVTIGMVGKYVDLTESYKSLIEALRHASI
HTSTKVNIEYIDSEELETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAVRYARESKVPYLGICLGMQLAVIEFARDVVGLK
QANSTEFDPDTPERVVALITEWYDREGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRFV
PQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFRSFVEAALANKQARGVQA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=565, Percent_Identity=44.9557522123894, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI28559083, Length=565, Percent_Identity=44.9557522123894, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI221316689, Length=565, Percent_Identity=44.9557522123894, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI148491070, Length=562, Percent_Identity=45.1957295373665, Blast_Score=477, Evalue=1e-134,
Organism=Escherichia coli, GI1789142, Length=550, Percent_Identity=62.3636363636364, Blast_Score=688, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=40.8866995073892, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=42.280701754386, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322563, Length=574, Percent_Identity=42.6829268292683, Blast_Score=451, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=45.1785714285714, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.7623762376238, Blast_Score=404, Evalue=1e-112,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61236; Mature: 61104

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEE
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSALVEKLENPKQEVTIGMVG
EEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHEEHHHHH
KYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGVDSLKHLDAVLVPGGFGRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAVRYARESKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCCCCCCHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFRSFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKQARGVQA
HHHCCCCCCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYVATAGELKTKPTQHSVQKLREIGILPHVLLCRADRRIPDDESKKISMFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEE
SVWDADSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSALVEKLENPKQEVTIGMVG
EEECCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHEEHHHHH
KYVDLTESYKSLIEALRHASIHTSTKVNIEYIDSEELETNGVDSLKHLDAVLVPGGFGRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAVRYARESKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVETRTEESDLGGTMRLGSQRCPIKPGTMAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCCCCCCCHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLEAGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFRSFVEA
CCEECCCCEEEECCCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKQARGVQA
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA