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The map label for this gene is mprB [H]

Identifier: 116690086

GI number: 116690086

Start: 2292643

End: 2294034

Strand: Reverse

Name: mprB [H]

Synonym: Bcen2424_2065

Alternate gene names: 116690086

Gene position: 2294034-2292643 (Counterclockwise)

Preceding gene: 116690087

Following gene: 116690085

Centisome position: 65.85

GC content: 69.11

Gene sequence:

>1392_bases
ATGGACGCAGCCCGCGCGGCGCACTTCACGCGCCGCTGGCATACGACGACGTTTCGCTGGCTATGCGCATACGCGGCGAT
CTTCTCGGTGTCGCTGCTGCTGCTCGCGGGCGTGATCAGCGTGGCCGCGACGCATACGATGACGCGCAACACCGACGAAG
TGCTCGCGTGGCAACTGATCTATTTCGATTCGATTCCGGATGCCGAGCTGCCGCTCGCGATCCACCGGCGGCTCGAGCAC
GAGCACATGCATACGAATTTCTACGGGTTGTTCGATGCGAGCGGGCGCCGCGTGGCCGGCGACATCACGACGCCGCCCGC
GCTGCAGACCGATCGCCGCGGCCGGACGCTGAACCGCACGCTCGCACTGCTCGACGGCCAGCCGTCGCCGATCGCGCGCG
CGATGGCCGTGCGCCGCGACAACGGCATGACGCTGGTGGTCGCGCGCGACCTGTCGCATTTCATCCAGATCCGCGACGTC
GCGATCCGCGGGCTCGTGATCGGCGGCGTGGTGATCCTGATCGCGGGCATCGCGGGCGGCAGCATGCTCGGCATGCGGCA
GATGCGCCGCGTCGCCGCGATCCGGCGCGTCACGCGACAGATCGCCGAAGGTGATCTCGGCAAGCGACTGCCGGTCGGCG
GCTACGATGAACTCGATCTGCTCGCGCATCTCGTGAACCACATGCTCGACGAAGTCGAGCGGCTGATGGGCGAGGTGCGC
CATACCTGCGACGGGATCGCACACGACCTGCGCACGCCGCTCGCACGCGTGCATACGATGCTGGCGCGGCTCGCCGACCA
GCCGTTCTGCGCGCATGATCCCGCGTCGGCGGCGCTGCTGGCTTCGGCGCGCGACGAAACCGACCGGTTGCTCGAACGGT
TTCGCGCGATGCTGCGCATCTCCGAGATCGGCACGCTGAGCCGGCGCGGCGGTTTTGCCGCGGTCGACGTCGCGGCCCTG
CTGCGCGACGTGTGCGAGCTTTACGAGCCGCTGGCCGAGGATGTCGACGTGTCGTTCGCGCTCGAAGCGGCCACGGTCGG
CGGCATCCATGGCGATCGTGCGTTGCTGTTCGAGGCGTTCAGTAATCTCGCGGACAACGCGATCAAGTTCACGCCGCCGG
GCGGCCGCGTGCGCGTCGTGCTCCAGACGACGCCGCACGGCCCGCTCGTCCGGTTCGAGGACACCGGGCCCGGCATTCCG
CCCGGCGAGCGCAATGCGGTGCTCGAACGCTTCTACCGCGGCGAGCGCACGCGCCACGTGAACGGCTCGGGGCTCGGCTT
GAGCATCGTGTCGGCGGTGATGCGCGTGCATGGTTTCGCGCTGCGGATCGGCGACGCGCAGCCGGCCGGTACGGCGATCA
CGGTCGAATGCTGGCCGCGTTCGCTCGCATGA

Upstream 100 bases:

>100_bases
ACATGGGCCGGCTGCGCAAGAAGATCGATCCGCCCGGCGCGAACCCGATGATCCAGACGGTGCGCGGATCGGGCTACATG
CTCGCTTGACGGAGGCGCGA

Downstream 100 bases:

>100_bases
CGACGCGGGAGACCGAGCGATGCGCATCCTGCTGATCGCGCCGCCGAATCCGCACGCGTCGCGGCTCGACAAGGCGTTTC
GAGAGAGCACGCACGGCGTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDAARAAHFTRRWHTTTFRWLCAYAAIFSVSLLLLAGVISVAATHTMTRNTDEVLAWQLIYFDSIPDAELPLAIHRRLEH
EHMHTNFYGLFDASGRRVAGDITTPPALQTDRRGRTLNRTLALLDGQPSPIARAMAVRRDNGMTLVVARDLSHFIQIRDV
AIRGLVIGGVVILIAGIAGGSMLGMRQMRRVAAIRRVTRQIAEGDLGKRLPVGGYDELDLLAHLVNHMLDEVERLMGEVR
HTCDGIAHDLRTPLARVHTMLARLADQPFCAHDPASAALLASARDETDRLLERFRAMLRISEIGTLSRRGGFAAVDVAAL
LRDVCELYEPLAEDVDVSFALEAATVGGIHGDRALLFEAFSNLADNAIKFTPPGGRVRVVLQTTPHGPLVRFEDTGPGIP
PGERNAVLERFYRGERTRHVNGSGLGLSIVSAVMRVHGFALRIGDAQPAGTAITVECWPRSLA

Sequences:

>Translated_463_residues
MDAARAAHFTRRWHTTTFRWLCAYAAIFSVSLLLLAGVISVAATHTMTRNTDEVLAWQLIYFDSIPDAELPLAIHRRLEH
EHMHTNFYGLFDASGRRVAGDITTPPALQTDRRGRTLNRTLALLDGQPSPIARAMAVRRDNGMTLVVARDLSHFIQIRDV
AIRGLVIGGVVILIAGIAGGSMLGMRQMRRVAAIRRVTRQIAEGDLGKRLPVGGYDELDLLAHLVNHMLDEVERLMGEVR
HTCDGIAHDLRTPLARVHTMLARLADQPFCAHDPASAALLASARDETDRLLERFRAMLRISEIGTLSRRGGFAAVDVAAL
LRDVCELYEPLAEDVDVSFALEAATVGGIHGDRALLFEAFSNLADNAIKFTPPGGRVRVVLQTTPHGPLVRFEDTGPGIP
PGERNAVLERFYRGERTRHVNGSGLGLSIVSAVMRVHGFALRIGDAQPAGTAITVECWPRSLA
>Mature_463_residues
MDAARAAHFTRRWHTTTFRWLCAYAAIFSVSLLLLAGVISVAATHTMTRNTDEVLAWQLIYFDSIPDAELPLAIHRRLEH
EHMHTNFYGLFDASGRRVAGDITTPPALQTDRRGRTLNRTLALLDGQPSPIARAMAVRRDNGMTLVVARDLSHFIQIRDV
AIRGLVIGGVVILIAGIAGGSMLGMRQMRRVAAIRRVTRQIAEGDLGKRLPVGGYDELDLLAHLVNHMLDEVERLMGEVR
HTCDGIAHDLRTPLARVHTMLARLADQPFCAHDPASAALLASARDETDRLLERFRAMLRISEIGTLSRRGGFAAVDVAAL
LRDVCELYEPLAEDVDVSFALEAATVGGIHGDRALLFEAFSNLADNAIKFTPPGGRVRVVLQTTPHGPLVRFEDTGPGIP
PGERNAVLERFYRGERTRHVNGSGLGLSIVSAVMRVHGFALRIGDAQPAGTAITVECWPRSLA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=31.858407079646, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=30.7086614173228, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.8388278388278, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789808, Length=287, Percent_Identity=25.7839721254355, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789403, Length=458, Percent_Identity=26.8558951965066, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=24.7349823321555, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=263, Percent_Identity=31.5589353612167, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790861, Length=249, Percent_Identity=29.3172690763052, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=204, Percent_Identity=28.921568627451, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=296, Percent_Identity=26.0135135135135, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=21.8867924528302, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=21.7021276595745, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50713; Mature: 50713

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAARAAHFTRRWHTTTFRWLCAYAAIFSVSLLLLAGVISVAATHTMTRNTDEVLAWQLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEE
YFDSIPDAELPLAIHRRLEHEHMHTNFYGLFDASGRRVAGDITTPPALQTDRRGRTLNRT
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHE
LALLDGQPSPIARAMAVRRDNGMTLVVARDLSHFIQIRDVAIRGLVIGGVVILIAGIAGG
EEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SMLGMRQMRRVAAIRRVTRQIAEGDLGKRLPVGGYDELDLLAHLVNHMLDEVERLMGEVR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTCDGIAHDLRTPLARVHTMLARLADQPFCAHDPASAALLASARDETDRLLERFRAMLRI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
SEIGTLSRRGGFAAVDVAALLRDVCELYEPLAEDVDVSFALEAATVGGIHGDRALLFEAF
HHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHH
SNLADNAIKFTPPGGRVRVVLQTTPHGPLVRFEDTGPGIPPGERNAVLERFYRGERTRHV
HHHHCCCEEECCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEC
NGSGLGLSIVSAVMRVHGFALRIGDAQPAGTAITVECWPRSLA
CCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MDAARAAHFTRRWHTTTFRWLCAYAAIFSVSLLLLAGVISVAATHTMTRNTDEVLAWQLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEE
YFDSIPDAELPLAIHRRLEHEHMHTNFYGLFDASGRRVAGDITTPPALQTDRRGRTLNRT
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCHHHHE
LALLDGQPSPIARAMAVRRDNGMTLVVARDLSHFIQIRDVAIRGLVIGGVVILIAGIAGG
EEEECCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SMLGMRQMRRVAAIRRVTRQIAEGDLGKRLPVGGYDELDLLAHLVNHMLDEVERLMGEVR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTCDGIAHDLRTPLARVHTMLARLADQPFCAHDPASAALLASARDETDRLLERFRAMLRI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
SEIGTLSRRGGFAAVDVAALLRDVCELYEPLAEDVDVSFALEAATVGGIHGDRALLFEAF
HHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCCHHHHHHHH
SNLADNAIKFTPPGGRVRVVLQTTPHGPLVRFEDTGPGIPPGERNAVLERFYRGERTRHV
HHHHCCCEEECCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCEEC
NGSGLGLSIVSAVMRVHGFALRIGDAQPAGTAITVECWPRSLA
CCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA