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The map label for this gene is cusR [H]

Identifier: 116690087

GI number: 116690087

Start: 2294046

End: 2294720

Strand: Reverse

Name: cusR [H]

Synonym: Bcen2424_2066

Alternate gene names: 116690087

Gene position: 2294720-2294046 (Counterclockwise)

Preceding gene: 116690089

Following gene: 116690086

Centisome position: 65.87

GC content: 66.96

Gene sequence:

>675_bases
ATGCGAGTACTGACGGTCGAGGACGATGCGGTGACCGCGAACGAAATCGTCGGCGAACTGACCGCCCGCGGGTTCGAGGT
CGACTGGACCGATAACGGCCGCGAAGGGATGATGCGCGCGATGAGCGCATCGTACGACGCGATCACGCTCGACCGGATGC
TGCCGGGCGCGGACGGCCTCGCGATCGTGACTGCGATGCGCACGGTCGGCATCGACACGCCGGTGCTGATGCTGAGCGCG
CTGGGCGACGTCGACGAGCGCATCCGCGGGCTGCGCGCTGGCGGCGACGATTACCTGACGAAGCCGTTCGATTCCGGCGA
ACTGAGCGCGCGCATCGAAGTGCTGCTGCGCCGCCGGCAGGCATCGGGTGTGCCGCAGCAGACGCTGCTGAAGGTCGGCG
CGCTCGAGCTCGACCTCATTTCGCGCTGCGCGCGCCGCGGCGCCGACGAGATTCCGCTGCTGCCGACCGAGTTCCGCGTG
CTCGAATTCATGATGCGTAACGCAGGCCAGACGATCACGCGCACGATGCTGTTCGAGGCCGTGTGGGGCTATCACTTCGA
TCCCGGCACCAACCTGATCGACGTTCACATGGGCCGGCTGCGCAAGAAGATCGATCCGCCCGGCGCGAACCCGATGATCC
AGACGGTGCGCGGATCGGGCTACATGCTCGCTTGA

Upstream 100 bases:

>100_bases
TGAAGTTATTTTCATCTGGCGCCGCACGGCAATCGCGGCGCTTACGATAGTGGCGGGCGCATCGTGCGCGCCCGTGTTGA
AGTTCATTGCGAGGGCAACC

Downstream 100 bases:

>100_bases
CGGAGGCGCGAATGGACGCAGCCCGCGCGGCGCACTTCACGCGCCGCTGGCATACGACGACGTTTCGCTGGCTATGCGCA
TACGCGGCGATCTTCTCGGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRVLTVEDDAVTANEIVGELTARGFEVDWTDNGREGMMRAMSASYDAITLDRMLPGADGLAIVTAMRTVGIDTPVLMLSA
LGDVDERIRGLRAGGDDYLTKPFDSGELSARIEVLLRRRQASGVPQQTLLKVGALELDLISRCARRGADEIPLLPTEFRV
LEFMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRKKIDPPGANPMIQTVRGSGYMLA

Sequences:

>Translated_224_residues
MRVLTVEDDAVTANEIVGELTARGFEVDWTDNGREGMMRAMSASYDAITLDRMLPGADGLAIVTAMRTVGIDTPVLMLSA
LGDVDERIRGLRAGGDDYLTKPFDSGELSARIEVLLRRRQASGVPQQTLLKVGALELDLISRCARRGADEIPLLPTEFRV
LEFMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRKKIDPPGANPMIQTVRGSGYMLA
>Mature_224_residues
MRVLTVEDDAVTANEIVGELTARGFEVDWTDNGREGMMRAMSASYDAITLDRMLPGADGLAIVTAMRTVGIDTPVLMLSA
LGDVDERIRGLRAGGDDYLTKPFDSGELSARIEVLLRRRQASGVPQQTLLKVGALELDLISRCARRGADEIPLLPTEFRV
LEFMMRNAGQTITRTMLFEAVWGYHFDPGTNLIDVHMGRLRKKIDPPGANPMIQTVRGSGYMLA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=44.3946188340807, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.4615384615385, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.4618834080717, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.1111111111111, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.9775784753363, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=35.9090909090909, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.9344978165939, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.2869955156951, Blast_Score=116, Evalue=9e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.0175438596491, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.5555555555556, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=30.6666666666667, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.1724137931034, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.1688311688312, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.0172413793103, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24655; Mature: 24655

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLTVEDDAVTANEIVGELTARGFEVDWTDNGREGMMRAMSASYDAITLDRMLPGADGL
CEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEHHHHCCCCCCH
AIVTAMRTVGIDTPVLMLSALGDVDERIRGLRAGGDDYLTKPFDSGELSARIEVLLRRRQ
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ASGVPQQTLLKVGALELDLISRCARRGADEIPLLPTEFRVLEFMMRNAGQTITRTMLFEA
HCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
VWGYHFDPGTNLIDVHMGRLRKKIDPPGANPMIQTVRGSGYMLA
HHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCC
>Mature Secondary Structure
MRVLTVEDDAVTANEIVGELTARGFEVDWTDNGREGMMRAMSASYDAITLDRMLPGADGL
CEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCEEEHHHHCCCCCCH
AIVTAMRTVGIDTPVLMLSALGDVDERIRGLRAGGDDYLTKPFDSGELSARIEVLLRRRQ
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ASGVPQQTLLKVGALELDLISRCARRGADEIPLLPTEFRVLEFMMRNAGQTITRTMLFEA
HCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
VWGYHFDPGTNLIDVHMGRLRKKIDPPGANPMIQTVRGSGYMLA
HHCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]