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The map label for this gene is thrC [H]

Identifier: 116689874

GI number: 116689874

Start: 2057381

End: 2058832

Strand: Reverse

Name: thrC [H]

Synonym: Bcen2424_1853

Alternate gene names: 116689874

Gene position: 2058832-2057381 (Counterclockwise)

Preceding gene: 116689875

Following gene: 116689873

Centisome position: 59.1

GC content: 66.32

Gene sequence:

>1452_bases
ATGAACTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCATACGTTCTCCGACATCCTGCTCGGCGGTCTCGCGAA
GGACGGCGGCCTCTACCTGCCGGCCGAGTATCCGAAGGTGTCCGCCGACGAGCTCGCGCGCTGGCGCACGCTGTCGTACG
CGGATCTCGCGTTCGAGATCCTGTCGAAGTTCTGCGACGACGTGCCGGCCGACGACCTGCGCGCGATCACGCGCCGTACC
TACACGGCTGCCGTGTACAGCAACACGCGCCACGGCGAGAACGCATCCGACATCACGCCGCTGAAGACGCTCGGCACCGA
GCACGGCACGGCGCTGTCGCTGCTCGAACTGTCGAACGGCCCGACGCTCGCGTTCAAGGACATGGCGATGCAGTTGCTCG
GCAACCTGTTCGAGTACACGCTCGCGAAGCACGGCGAAGCGCTGAACATCCTCGGCGCGACGTCGGGCGACACCGGCAGC
GCGGCCGAATACGCGATGCGCGGCAAGGCCGGCGTGCGCGTGTTCATGCTGTCGCCGCACAAGAAGATGAGCGCGTTCCA
GACGGCGCAGATGTTCAGCCTGCAGGACCCGAACATCTTCAACCTCGCGGTCGAAGGCGTGTTCGACGACTGCCAGGACA
TCGTGAAGGCCGTGTCGAACGATCACGCGTTCAAGGCGCAGCAGAAGATCGGCACCGTCAACTCGATCAACTGGGCGCGC
GTCGTCGCGCAGGTCGTGTACTACTTCAAGGGCTATTTCGCGGCGACGCGGTCGAACGACGAGCGCGTGTCGTTCACGGT
GCCGTCGGGCAACTTCGGCAACGTCTGCGCGGGCCACATCGCGCGGATGATGGGGCTGCCGATCGCGAAGCTGGTGGTCG
CGACCAACGAGAACGACGTGCTCGACGAATTCTTCCGCACCGGCGCGTATCGCGTGCGCAGCGCCGAGCACACCTATCAC
ACGAGCAGCCCGAGCATGGACATCTCGAAGGCATCGAACTTCGAGCGCTTCGTGTTCGACCTGCTCGGCCGCGATCCGGC
GCGCGTGATGCAACTGTTCCGCGACGTCGAGGAGAAGGGCGGCTTCGATCTCGCGGCGAGCGGCGATTTCGCGCGCGTGG
CCGAATTCGGTTTCGTGTCGGGCCGCAGCAGCCACACCGACCGCATCGCGACGATCCGCGACGTGTTCTCGCGCTACGAC
ACGATGATCGATACGCATACGGCCGACGGCGTGAAGGTCGCGCGCGAGCATCTGGAGGCCGGCGTGCCGATGGTCGTGCT
CGAGACGGCGCAGCCGATCAAGTTCGGCGAGACGATCCGCGAAGCGCTCGATCGCGAAGCCGAGCGGCCGGCCGCCTTCG
ACGGGCTCGAGGCGCTGCCGCAGCGCTTCGAGGTCGTGAAGGCCGACGCGCAGCAGGTGAAGGACTTCATCGCCGCCCAT
ACGGGCGCATGA

Upstream 100 bases:

>100_bases
AAAAACGTCAACGCGGCGATCGCGCAGATCGAGAGCCTGGCGACGGTGGTCTCGAAGGTAACGAAGCTGCGCATGGAAGC
GCTGAACTGAGGCTGACGAC

Downstream 100 bases:

>100_bases
CGCACGGCCGGGCCCGCGGGCCCGGCGGCGCAGGACGGCCGGAATGCCGATTCGTCGAACGGATCGGGGTTCCGGCCGTT
TCGTTTGGTACTCAGGTTTG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPAEYPKVSADELARWRTLSYADLAFEILSKFCDDVPADDLRAITRRT
YTAAVYSNTRHGENASDITPLKTLGTEHGTALSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGEALNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSSHTDRIATIRDVFSRYD
TMIDTHTADGVKVAREHLEAGVPMVVLETAQPIKFGETIREALDREAERPAAFDGLEALPQRFEVVKADAQQVKDFIAAH
TGA

Sequences:

>Translated_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPAEYPKVSADELARWRTLSYADLAFEILSKFCDDVPADDLRAITRRT
YTAAVYSNTRHGENASDITPLKTLGTEHGTALSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGEALNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSSHTDRIATIRDVFSRYD
TMIDTHTADGVKVAREHLEAGVPMVVLETAQPIKFGETIREALDREAERPAAFDGLEALPQRFEVVKADAQQVKDFIAAH
TGA
>Mature_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPAEYPKVSADELARWRTLSYADLAFEILSKFCDDVPADDLRAITRRT
YTAAVYSNTRHGENASDITPLKTLGTEHGTALSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGEALNILGATSGDTGS
AAEYAMRGKAGVRVFMLSPHKKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDVLDEFFRTGAYRVRSAEHTYH
TSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEEKGGFDLAASGDFARVAEFGFVSGRSSHTDRIATIRDVFSRYD
TMIDTHTADGVKVAREHLEAGVPMVVLETAQPIKFGETIREALDREAERPAAFDGLEALPQRFEVVKADAQQVKDFIAAH
TGA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=451, Percent_Identity=33.7028824833703, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI149193323, Length=466, Percent_Identity=30.9012875536481, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1786185, Length=469, Percent_Identity=28.1449893390192, Blast_Score=179, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319901, Length=471, Percent_Identity=39.2781316348195, Blast_Score=310, Evalue=3e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52968; Mature: 52968

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPAEYPKVSADELARWRTLSYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHH
LSKFCDDVPADDLRAITRRTYTAAVYSNTRHGENASDITPLKTLGTEHGTALSLLELSNG
HHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGEALNILGATSGDTGSAAEYAMRGKAGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCC
KKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAEHTYHTSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEEKG
HHHHHHCCCCEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSSHTDRIATIRDVFSRYDTMIDTHTADGVKVAREHLEA
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVPMVVLETAQPIKFGETIREALDREAERPAAFDGLEALPQRFEVVKADAQQVKDFIAAH
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGA
CCC
>Mature Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPAEYPKVSADELARWRTLSYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHH
LSKFCDDVPADDLRAITRRTYTAAVYSNTRHGENASDITPLKTLGTEHGTALSLLELSNG
HHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGEALNILGATSGDTGSAAEYAMRGKAGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCC
KKMSAFQTAQMFSLQDPNIFNLAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIAKLVVATNENDV
HHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAEHTYHTSSPSMDISKASNFERFVFDLLGRDPARVMQLFRDVEEKG
HHHHHHCCCCEEECCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSSHTDRIATIRDVFSRYDTMIDTHTADGVKVAREHLEA
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVPMVVLETAQPIKFGETIREALDREAERPAAFDGLEALPQRFEVVKADAQQVKDFIAAH
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]