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The map label for this gene is hom [H]

Identifier: 116689875

GI number: 116689875

Start: 2058843

End: 2060171

Strand: Reverse

Name: hom [H]

Synonym: Bcen2424_1854

Alternate gene names: 116689875

Gene position: 2060171-2058843 (Counterclockwise)

Preceding gene: 116689876

Following gene: 116689874

Centisome position: 59.13

GC content: 67.04

Gene sequence:

>1329_bases
ATGGAACCGATCAAAGTTGGCCTGTTGGGCTTCGGCACCGTCGGCAGCGGCACCTTCACGGTGTTGCACCGCAACCAGGA
AGAAATCAAACGACGCGCGGGGCGCGGCATCGAGGTCGCGCGCATTGCCGTGCGCAACCCCGCCAAGGCGCAGGCCGCGC
TCGGCGGCAACGCCGGCACCGCGCAGATCACCGATGATTTCAATGCGGTCGTCGACGATCCGTCGATCGCGATCATCGCC
GAGATGATCGGCGGCACGGGCATCGCGCGCGAGCTCGTGCTGCGCGCGATCGCGAACGGCAAGCACGTCGTGACGGCGAA
CAAGGCGCTGCTCGCGGTGCACGGCACCGAGATCTTCGAAGCCGCGCGCGAGAAGGGCGTGATGGTCGCGTTCGAGGCGG
CCGTCGCCGGTGGCATCCCGATCATCAAGGCGCTGCGCGAAGGCCTGACCGCGAACCGCATCCAGTACATCGCCGGCATC
ATCAACGGCACGACGAACTACATCCTGTCGGAAATGCGCGACCGCGGGCTCGACTTCGCGACCGCGCTGAAGGCCGCGCA
GGAGCTCGGCTACGCGGAAGCCGATCCGACCTTCGACATCGAAGGCGTCGACGCCGCGCACAAGGCGACGATCATGAGCG
CGATCGCGTTCGGCGTGCCGGTGCAGTTCGACCGCGCGTACGTCGAGGGCATCAGCAAGCTCGACGCGACCGACATCCGC
TATGCGGAAGAACTCGGCTACCGGATCAAGCTGCTCGGCATCGCGCGCCGCGCCGCCAACGGCATCGAGCTGCGCGTGCA
CCCGACGCTGATCCCGGAAAAGCGCCTGCTCGCGAACGTCGAGGGCGCGATGAACGCGGTCGTCGTGCACGGCGATGCAG
TCGGCACGACGCTGTACTACGGCAAGGGCGCGGGCGCGGAGCCGACCGCGTCGGCCGTCGTCGCGGATCTGGTCGACGTC
ACGCGCCTGCACACGGCCGATCCCGAGCATCGCGTGCCGCACCTCGCATTCCAGCCGGACAGCCTGTCGAACACGCCGAT
TTTGCCGATCGAGGAAGTGACGAGCGGCTACTACCTGCGCCTGCGCGTGGCCGACCAGACCGGCGTGCTCGCCGCGATCA
CGCGCATCCTCGCCGAATCGGGCATCTCGATCGACGCGCTGCTGCAGAAGGAGTCGGAGCAGATCGACGGCGCGAACGGC
GAGACCGACATCATCCTGATCACGCACGAGACGGTCGAGAAAAACGTCAACGCGGCGATCGCGCAGATCGAGAGCCTGGC
GACGGTGGTCTCGAAGGTAACGAAGCTGCGCATGGAAGCGCTGAACTGA

Upstream 100 bases:

>100_bases
GGATCGCACGCTTCCTCGACGGCTACCGCAAGCGCCATTCGGTCTGAGCGGGCAGGGCCACACGGAACTCACTACTTCTT
ACTCATCGATCACACGCAGC

Downstream 100 bases:

>100_bases
GGCTGACGACATGAACTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCATACGTTCTCCGACATCCTGCTCGGCG
GTCTCGCGAAGGACGGCGGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEPIKVGLLGFGTVGSGTFTVLHRNQEEIKRRAGRGIEVARIAVRNPAKAQAALGGNAGTAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISKLDATDIR
YAEELGYRIKLLGIARRAANGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLAAITRILAESGISIDALLQKESEQIDGANG
ETDIILITHETVEKNVNAAIAQIESLATVVSKVTKLRMEALN

Sequences:

>Translated_442_residues
MEPIKVGLLGFGTVGSGTFTVLHRNQEEIKRRAGRGIEVARIAVRNPAKAQAALGGNAGTAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISKLDATDIR
YAEELGYRIKLLGIARRAANGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLAAITRILAESGISIDALLQKESEQIDGANG
ETDIILITHETVEKNVNAAIAQIESLATVVSKVTKLRMEALN
>Mature_442_residues
MEPIKVGLLGFGTVGSGTFTVLHRNQEEIKRRAGRGIEVARIAVRNPAKAQAALGGNAGTAQITDDFNAVVDDPSIAIIA
EMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMRDRGLDFATALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISKLDATDIR
YAEELGYRIKLLGIARRAANGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADQTGVLAAITRILAESGISIDALLQKESEQIDGANG
ETDIILITHETVEKNVNAAIAQIESLATVVSKVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=135, Percent_Identity=34.8148148148148, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46871; Mature: 46871

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLHRNQEEIKRRAGRGIEVARIAVRNPAKAQAALGGNAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCC
AQITDDFNAVVDDPSIAIIAEMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEEECCCHHEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISKLDATDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCHHHHH
YAEELGYRIKLLGIARRAANGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLAAITRILAESGISIDALLQKESEQIDGANGETDIILITHETVEKNVNAAI
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHH
AQIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGSGTFTVLHRNQEEIKRRAGRGIEVARIAVRNPAKAQAALGGNAGT
CCCEEEEEEEECCCCCCEEEEEECCHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCC
AQITDDFNAVVDDPSIAIIAEMIGGTGIARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEEECCCHHEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDRAYVEGISKLDATDIR
HHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCHHHHH
YAEELGYRIKLLGIARRAANGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADQTGVLAAITRILAESGISIDALLQKESEQIDGANGETDIILITHETVEKNVNAAI
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHH
AQIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]