Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 116689113

GI number: 116689113

Start: 1202534

End: 1203928

Strand: Reverse

Name: fumC [H]

Synonym: Bcen2424_1090

Alternate gene names: 116689113

Gene position: 1203928-1202534 (Counterclockwise)

Preceding gene: 116689114

Following gene: 116689111

Centisome position: 34.56

GC content: 67.67

Gene sequence:

>1395_bases
ATGAATGAAGCAGTTCGGATGGAACGCGACACGTTCGGCGAGATCGCCGTGCCGGCCGACCGGCTCTGGGGCGCGCAGAC
CGAGCGCTCGCTGCAGAATTTCCGGATCTCGACGGAGAAGCAGTCGCCCGAGCTGATCCACGCGCTCGCGATCGTCAAGC
GCGCCGCGGCGGCCGTCAACCAGTCGCTCGGCGTGCTCGCCGACGACAAGGCGCACGCGATCATCGAAGCCGCCGACGAG
ATCATCGCCGGCAAGCATCCGCGCGAATTCCCGCTGGCGGTGTGGCAGACGGGCTCCGGCACGCAGACCAACATGAACCT
CAACGAGGTGATCGCGAACCGCGCGAGCGAGCTGCTGGGCGGCGAGCGCGGCGAAGCGCGCAAGGTTCATCCGAACGACG
ACGTGAACCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCGATGCACATCGCGGCCGCGTATGCGATCGTCAATCAC
CTGCTGCCGGCGCTGCGCACGCTGCGCGCGACGCTCGACGCGAAGTCGAAGGCGTTCGCCGACATCGTCAAGATCGGCCG
CACCCACCTGCAGGACGCCACGCCGCTCACGCTCGGCCAGGAGTTCTCCGGCTACGTCGCGCAGCTCGACCAGGGCATCC
GTCACGTCGAATCGGCGCTGCCGCACCTGTACGAACTCGCGCTCGGCGGCACCGCGGTCGGCACGGGGCTGAACGCGCAT
CCGGAGTTCGCGGTGCGCGTGGCCGACGAGATCGGCCGGCTCGCGAAGCTGCCGTTCGTGACGGCGCCGAGCAAGTTCGA
GGTGATGGCGGCCGCCGACGCGCTGGTTTTCGCGCACGGCGCGCTGAAAACGGTCGCAGCCAGCCTGATGAAGATCGCGA
ACGACGTGCGCTGGCTCGCGAGCGGGCCGCGCTGCGGGCTCGGCGAGCTGTCGATTCCGGAAAACGAGCCGGGCAGCTCG
ATCATGCCGGGCAAGGTGAATCCGACGCAGTCGGAAGCCGTGACGATGCTGTGCTGCCAGGTGTTCGGCAACGACGTCGC
GGTCAACGTCGGCGGCGCGAGCGGCAACTTCGAGCTGAACGTGTTCCGGCCGATGATCGCGCACAATGTGCTGCAGTCGG
TGCGGCTGCTCGCCGACGGCGCGCAGAGCTTCAACGATCACTGCGCGGTGGGCATCGAGCCGAACCGCTCGCGCATCGAC
CTGTTGCTGAACGAATCGCTGATGCTCGTGACGGCGCTCAATCCGCACATCGGCTACGACAAGTCCGCGCAGATCGCGAA
GAAGGCGCACAAGGAAGGCACGACGCTGAAGGCGGCCGCGCTCGCGCTCGGCTACCTGACCGAGGCGGAATTCGATGCAT
GGGTGCGCCCCGAGCAGATGATCGGGACGCGATAA

Upstream 100 bases:

>100_bases
AGACGCCGCGCAAGCGGCGCGACTGCCTCACGATACGTCTGATTACGCCTGACGCCGCGCGACGACGCGCGGCCTTTCCC
CTTTCCCGGAGGAGTGCATC

Downstream 100 bases:

>100_bases
AGGCAGGACGGCGGGCGCGGCGCGTCGAGCGCGGCGCCCGTCGCGCTCAGACCGCGCCCTTCGCGACCTCTTCCGGCTTC
ATCTCGACGATCTTGTCGAG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAHAIIEAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGEARKVHPNDDVNRGQSSNDVFPTAMHIAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGTR

Sequences:

>Translated_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAHAIIEAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGEARKVHPNDDVNRGQSSNDVFPTAMHIAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGTR
>Mature_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAHAIIEAADE
IIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELLGGERGEARKVHPNDDVNRGQSSNDVFPTAMHIAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRID
LLLNESLMLVTALNPHIGYDKSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGTR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=464, Percent_Identity=62.9310344827586, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=76.0348583877996, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=455, Percent_Identity=40, Blast_Score=339, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=63.4989200863931, Blast_Score=595, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=66.2576687116564, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6324993, Length=466, Percent_Identity=59.2274678111588, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=467, Percent_Identity=61.2419700214133, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640177, Length=467, Percent_Identity=61.2419700214133, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=60.9071274298056, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=59.2672413793103, Blast_Score=567, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=53.7960954446855, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49737; Mature: 49737

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKAHAIIEAADEIIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELLG
HCCCCEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHIAAAYAIVNHLLPALRTLRATLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLA
CHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCC
KSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGTR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCHHHCCCC
>Mature Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKAHAIIEAADEIIAGKHPREFPLAVWQTGSGTQTNMNLNEVIANRASELLG
HCCCCEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHIAAAYAIVNHLLPALRTLRATLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAVRVADEIGRLAKLPFVTAPSKFEVMAAADALVFAHGALKTVAASLMKIANDVRWLA
CHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRSRIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCC
KSAQIAKKAHKEGTTLKAAALALGYLTEAEFDAWVRPEQMIGTR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]