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The map label for this gene is lrp [H]

Identifier: 116689088

GI number: 116689088

Start: 1179874

End: 1180422

Strand: Direct

Name: lrp [H]

Synonym: Bcen2424_1065

Alternate gene names: 116689088

Gene position: 1179874-1180422 (Clockwise)

Preceding gene: 116689086

Following gene: 116689089

Centisome position: 33.87

GC content: 58.83

Gene sequence:

>549_bases
ATGGTATTGTCGAATGTGCAGTTTTTGTTATTGTATTTTTCTGGTTTTCAGCATAAACAAATGAGAACGCAACGTCAGCC
CGTACGCTCGCTCGATAAGCTCGACCGGCGCATCCTGAAACTGCTCCAGGACGACGGCCGGATGGCGATGAAAGACCTCG
CGGAACAGGTCGGCCTGACCGTCACGCCGTGCATCGAGCGCGTGAGGCGCATGGAGCGCGACGGCGTGATCACCGGCTAT
CACGCGCGGGTCGATCCGGGCCAGTTGGGGGCCGCGCTGCTGGTGTTCGTCGAGATCACGCTCGGCCACAAGGGCGGCAA
CATGTTCGAGCAATTCCGCCGGGAAGTGATGAAGATCGACGAGGTGCTCGAATGTCATCTCGTCTCCGGCGATTTCGACT
ATCTGATCAAGGCGCGGATCGGCGAGATGGCCGACTACCGGAAACTGCTGGGCGACATCCTGCTGCAGTTGCCCGGCGCC
GTGCAGTCGAAGAGCTATGTCGTGATGGAGGAAATCAAGGAAACGTTGACGATCGCCGTCGGCGAGTGA

Upstream 100 bases:

>100_bases
AATGACGACTCGCATAGCTGCTCCAGATCGAAGGAATCAGGTCGAGGCCGGGCGCACCTGCGGCTCCGTGTAACCTCTAG
CTGATCTAGTTTTTTGCGCT

Downstream 100 bases:

>100_bases
CGCGCCCGCGGCTCGTCGTCGGGCCCTTTATGCCGCCCTTGGCATGCTGCACCCAATACTGTATAAATGTACAGTATTGG
GTGCAGGCGAATGGGTGGGC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MVLSNVQFLLLYFSGFQHKQMRTQRQPVRSLDKLDRRILKLLQDDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGY
HARVDPGQLGAALLVFVEITLGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGA
VQSKSYVVMEEIKETLTIAVGE

Sequences:

>Translated_182_residues
MVLSNVQFLLLYFSGFQHKQMRTQRQPVRSLDKLDRRILKLLQDDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGY
HARVDPGQLGAALLVFVEITLGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGA
VQSKSYVVMEEIKETLTIAVGE
>Mature_182_residues
MVLSNVQFLLLYFSGFQHKQMRTQRQPVRSLDKLDRRILKLLQDDGRMAMKDLAEQVGLTVTPCIERVRRMERDGVITGY
HARVDPGQLGAALLVFVEITLGHKGGNMFEQFRREVMKIDEVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGA
VQSKSYVVMEEIKETLTIAVGE

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=54.2483660130719, Blast_Score=181, Evalue=2e-47,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=35.3333333333333, Blast_Score=108, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 20769; Mature: 20769

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSNVQFLLLYFSGFQHKQMRTQRQPVRSLDKLDRRILKLLQDDGRMAMKDLAEQVGLT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
VTPCIERVRRMERDGVITGYHARVDPGQLGAALLVFVEITLGHKGGNMFEQFRREVMKID
HHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
GE
CC
>Mature Secondary Structure
MVLSNVQFLLLYFSGFQHKQMRTQRQPVRSLDKLDRRILKLLQDDGRMAMKDLAEQVGLT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
VTPCIERVRRMERDGVITGYHARVDPGQLGAALLVFVEITLGHKGGNMFEQFRREVMKID
HHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EVLECHLVSGDFDYLIKARIGEMADYRKLLGDILLQLPGAVQSKSYVVMEEIKETLTIAV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
GE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]