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The map label for this gene is mltB [H]

Identifier: 116689079

GI number: 116689079

Start: 1170278

End: 1171243

Strand: Reverse

Name: mltB [H]

Synonym: Bcen2424_1056

Alternate gene names: 116689079

Gene position: 1171243-1170278 (Counterclockwise)

Preceding gene: 116689081

Following gene: 116689062

Centisome position: 33.62

GC content: 65.73

Gene sequence:

>966_bases
ATGGTGAGCCGCAACGGCTTCGATTCGGCGAGCCTGCATGCGCTGTTCTCGCGCATCAGCTACTCGGCGACGGCCGTCAA
GCTCGTGAGGCCGGCCCCGACGCCCTCGGTCAAGAACTGGCGCGTCTATCGCTCGCGCTTCATCGAACCGATCCGCATCA
ACGCGGGCGTGAAGTTCTGGAAGGCGAACCAGGCGGCGCTGCAGCGCGCGTCCGAGCAGTTCGGCGTGCCGCCCGAGGTG
ATCGTCGGCATCATCGGCGTCGAAACCATCTATGGCCGCTACATGGGCAATTTCCGCGTGCTGGACGCGCTGACGACGCT
AACATTCGACTACCCGGACACGCCGAATCGCGACAGCCGCCAGGCCACCTTCCGCAAGAACCTCGAAGACTTCCTGGTCT
GGACCCGCGACAACCAGCTCGACCCGACCACCGTGCTCGGCTCGTACACCGGCGCGATCGGGATTCCGCAGTTCCTGCCG
AGCAGCATCCGCGAATATGCGGTCGACTTCGACGGCACGGGCCACGTCGATCTGCGCAGCAGTCCTGTCGATGCGATCGG
CAGCGTCGCGAACTACCTGAAGCAGCACGGCTGGGAAACCGACCGACCGGTGGTCTGGCAGATCACGCCGGACACGGGCA
GTCTGGGCATCGCACAGGCCGCCGCCGACGGCCAGCCCGAACCGCACTGGGCGCTGTCGCAACTGCTGCGCGCCGGCATG
ACGCTGAACGAGCCGACGGTCAACATCACGACCGAAGCCGGCACGCCGGTGACGGTCGTCGACCTGCCGACGCCGGGGCG
TGCGACCGAATATATGCTCGGCCTGAAGAACTTCTATGTGTTGACGCGCTACAACCGCAGTTTCTTCTACGCACTCACCG
TGTACCAGCTCGGCGAAGCCGTGAAGGCGCAGATGGAAGCCAGTGGCGCGCTGCCACCCGCCGCTGCCGACGAGCAGCCG
CAGTAA

Upstream 100 bases:

>100_bases
CCAGCCGCAGCAGCCGACGCCGCAAGGCCAGACCTTCGAAGAGGAAATCGTTCCACAGCGTTACGCGAGCAACGCGAAGG
TCGATGCATTCATCGACGAG

Downstream 100 bases:

>100_bases
GCGCTGGCCGCCCAAAGAAAAAGCGCCGCAGAAGCGGCGCTTTTTTTATCGATGCGCGCCTCGCGCACCGATCTCGCTCA
GGCGGGAAACACACCCGTGG

Product: lytic murein transglycosylase B

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MVSRNGFDSASLHALFSRISYSATAVKLVRPAPTPSVKNWRVYRSRFIEPIRINAGVKFWKANQAALQRASEQFGVPPEV
IVGIIGVETIYGRYMGNFRVLDALTTLTFDYPDTPNRDSRQATFRKNLEDFLVWTRDNQLDPTTVLGSYTGAIGIPQFLP
SSIREYAVDFDGTGHVDLRSSPVDAIGSVANYLKQHGWETDRPVVWQITPDTGSLGIAQAAADGQPEPHWALSQLLRAGM
TLNEPTVNITTEAGTPVTVVDLPTPGRATEYMLGLKNFYVLTRYNRSFFYALTVYQLGEAVKAQMEASGALPPAAADEQP
Q

Sequences:

>Translated_321_residues
MVSRNGFDSASLHALFSRISYSATAVKLVRPAPTPSVKNWRVYRSRFIEPIRINAGVKFWKANQAALQRASEQFGVPPEV
IVGIIGVETIYGRYMGNFRVLDALTTLTFDYPDTPNRDSRQATFRKNLEDFLVWTRDNQLDPTTVLGSYTGAIGIPQFLP
SSIREYAVDFDGTGHVDLRSSPVDAIGSVANYLKQHGWETDRPVVWQITPDTGSLGIAQAAADGQPEPHWALSQLLRAGM
TLNEPTVNITTEAGTPVTVVDLPTPGRATEYMLGLKNFYVLTRYNRSFFYALTVYQLGEAVKAQMEASGALPPAAADEQP
Q
>Mature_321_residues
MVSRNGFDSASLHALFSRISYSATAVKLVRPAPTPSVKNWRVYRSRFIEPIRINAGVKFWKANQAALQRASEQFGVPPEV
IVGIIGVETIYGRYMGNFRVLDALTTLTFDYPDTPNRDSRQATFRKNLEDFLVWTRDNQLDPTTVLGSYTGAIGIPQFLP
SSIREYAVDFDGTGHVDLRSSPVDAIGSVANYLKQHGWETDRPVVWQITPDTGSLGIAQAAADGQPEPHWALSQLLRAGM
TLNEPTVNITTEAGTPVTVVDLPTPGRATEYMLGLKNFYVLTRYNRSFFYALTVYQLGEAVKAQMEASGALPPAAADEQP
Q

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=313, Percent_Identity=43.4504792332268, Blast_Score=227, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 35404; Mature: 35404

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSRNGFDSASLHALFSRISYSATAVKLVRPAPTPSVKNWRVYRSRFIEPIRINAGVKFW
CCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEECCCEEEE
KANQAALQRASEQFGVPPEVIVGIIGVETIYGRYMGNFRVLDALTTLTFDYPDTPNRDSR
ECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHEEECCCCCCCCCCH
QATFRKNLEDFLVWTRDNQLDPTTVLGSYTGAIGIPQFLPSSIREYAVDFDGTGHVDLRS
HHHHHHCHHHHEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCCEEECC
SPVDAIGSVANYLKQHGWETDRPVVWQITPDTGSLGIAQAAADGQPEPHWALSQLLRAGM
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCC
TLNEPTVNITTEAGTPVTVVDLPTPGRATEYMLGLKNFYVLTRYNRSFFYALTVYQLGEA
CCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEEEECCEEEEEHHHHHHHHH
VKAQMEASGALPPAAADEQPQ
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSRNGFDSASLHALFSRISYSATAVKLVRPAPTPSVKNWRVYRSRFIEPIRINAGVKFW
CCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCEEEECCCEEEE
KANQAALQRASEQFGVPPEVIVGIIGVETIYGRYMGNFRVLDALTTLTFDYPDTPNRDSR
ECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHEEECCCCCCCCCCH
QATFRKNLEDFLVWTRDNQLDPTTVLGSYTGAIGIPQFLPSSIREYAVDFDGTGHVDLRS
HHHHHHCHHHHEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHEECCCCCCCEEECC
SPVDAIGSVANYLKQHGWETDRPVVWQITPDTGSLGIAQAAADGQPEPHWALSQLLRAGM
CCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCC
TLNEPTVNITTEAGTPVTVVDLPTPGRATEYMLGLKNFYVLTRYNRSFFYALTVYQLGEA
CCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHEEEEEEECCEEEEEHHHHHHHHH
VKAQMEASGALPPAAADEQPQ
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]